U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ectopic hormone secretion syndrome associated with neoplasia

MedGen UID:
208863
•Concept ID:
C0851689
•
Disease or Syndrome
Synonyms: Ectopic Hormone Secretion Syndrome Associated with Neoplasia; ectopic hormone secretion syndrome associated with neoplasia; Neoplasm Associated Ectopic Hormone Secretion Syndrome; neoplasm associated ectopic hormone secretion syndrome
 
Monarch Initiative: MONDO:0045072

Definition

Abnormal secretion of hormones in conjunction with neoplastic growth occurring anywhere in the body. [from NCI]

Professional guidelines

PubMed

NAFLD in Some Common Endocrine Diseases: Prevalence, Pathophysiology, and Principles of Diagnosis and Management.
Lonardo A, Mantovani A, Lugari S, Targher G
Int J Mol Sci 2019 Jun 11;20(11) doi: 10.3390/ijms20112841. PMID: 31212642Free PMC Article
Advances in the medical treatment of Cushing's syndrome.
Feelders RA, Newell-Price J, Pivonello R, Nieman LK, Hofland LJ, Lacroix A
Lancet Diabetes Endocrinol 2019 Apr;7(4):300-312. Epub 2018 Jul 20 doi: 10.1016/S2213-8587(18)30155-4. PMID: 30033041
Ectopic Cushing's syndrome in light of modern diagnostic techniques and treatment options.
Witek P, Witek J, Zieliński G, Podgajny Z, Kamiński G
Neuro Endocrinol Lett 2015;36(3):201-8. PMID: 26313384

Recent clinical studies

Etiology

Diagnostic Strategy and Prognostic Factors for Ectopic Adrenocorticotropic Hormone Syndrome: A Retrospective Study of 64 Cases.
Chen W, Chen L, Pei L, Zeng R, Wu L, Wang C, Li Y, Xiao H, Cao X
Neuroendocrinology 2023;113(1):92-102. Epub 2022 Jul 26 doi: 10.1159/000526167. PMID: 35882186
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950
Ectopic ACTH syndrome.
Isidori AM, Kaltsas GA, Grossman AB
Front Horm Res 2006;35:143-156. doi: 10.1159/000094323. PMID: 16809930
Histopathology of the pituitary.
Doniach I
Clin Endocrinol Metab 1985 Nov;14(4):765-89. doi: 10.1016/s0300-595x(85)80077-3. PMID: 3002676
Multiple endocrine neoplasia syndromes.
Lips CJ, Vasen HF, Lamers CB
Crit Rev Oncol Hematol 1984;2(2):117-84. doi: 10.1016/s1040-8428(84)80017-7. PMID: 6152202

Diagnosis

Lung and Thymic Carcinoids.
Hann CL, Forde PM
Endocrinol Metab Clin North Am 2018 Sep;47(3):699-709. doi: 10.1016/j.ecl.2018.04.011. PMID: 30098725
Endocrine paraneoplastic syndromes in lung cancer.
Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Cushing's syndrome.
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950

Therapy

Intestinal Perforation in ACTH-Dependent Cushing's Syndrome.
Shahidi M, Phillips RA, Chik CL
Biomed Res Int 2019;2019:9721781. Epub 2019 Mar 13 doi: 10.1155/2019/9721781. PMID: 31001560Free PMC Article
Advances in the medical treatment of Cushing's syndrome.
Feelders RA, Newell-Price J, Pivonello R, Nieman LK, Hofland LJ, Lacroix A
Lancet Diabetes Endocrinol 2019 Apr;7(4):300-312. Epub 2018 Jul 20 doi: 10.1016/S2213-8587(18)30155-4. PMID: 30033041
Lung and Thymic Carcinoids.
Hann CL, Forde PM
Endocrinol Metab Clin North Am 2018 Sep;47(3):699-709. doi: 10.1016/j.ecl.2018.04.011. PMID: 30098725
Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours.
Dimitriadis GK, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2016 Sep;23(9):R423-36. Epub 2016 Jul 26 doi: 10.1530/ERC-16-0200. PMID: 27461388
Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review.
Ferlito A, Rinaldo A
Head Neck 2008 Apr;30(4):518-24. doi: 10.1002/hed.20797. PMID: 18302254

Prognosis

Lung and Thymic Carcinoids.
Hann CL, Forde PM
Endocrinol Metab Clin North Am 2018 Sep;47(3):699-709. doi: 10.1016/j.ecl.2018.04.011. PMID: 30098725
Endocrine paraneoplastic syndromes in lung cancer.
Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Cushing's syndrome.
Lacroix A, Feelders RA, Stratakis CA, Nieman LK
Lancet 2015 Aug 29;386(9996):913-27. Epub 2015 May 21 doi: 10.1016/S0140-6736(14)61375-1. PMID: 26004339
Cushing's disease.
De Martin M, Pecori Giraldi F, Cavagnini F
Pituitary 2006;9(4):279-87. doi: 10.1007/s11102-006-0407-6. PMID: 17077950
Ectopic ACTH syndrome.
Isidori AM, Kaltsas GA, Grossman AB
Front Horm Res 2006;35:143-156. doi: 10.1159/000094323. PMID: 16809930

Clinical prediction guides

Characterization of Outcomes by Surgical Management of Lung Neuroendocrine Tumors Associated With Cushing Syndrome.
Seastedt KP, Alyateem GA, Pittala K, Steinberg SM, Schrump DS, Nieman LK, Hoang CD
JAMA Netw Open 2021 Sep 1;4(9):e2124739. doi: 10.1001/jamanetworkopen.2021.24739. PMID: 34586369Free PMC Article
Radiologically defined lipid-poor adrenal adenomas: histopathological characteristics.
De Leo A, Mosconi C, Zavatta G, Tucci L, Nanni C, Selva S, Balacchi C, Ceccarelli C, Santini D, Pantaleo MA, Minni F, Fanti S, Golfieri R, Pagotto U, Vicennati V, Di Dalmazi G
J Endocrinol Invest 2020 Sep;43(9):1197-1204. Epub 2020 Feb 15 doi: 10.1007/s40618-020-01198-5. PMID: 32062826
Autoimmune Pituitary Disease: New Concepts With Clinical Implications.
Yamamoto M, Iguchi G, Bando H, Kanie K, Hidaka-Takeno R, Fukuoka H, Takahashi Y
Endocr Rev 2020 Apr 1;41(2) doi: 10.1210/endrev/bnz003. PMID: 31513261
ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature.
Maragliano R, Vanoli A, Albarello L, Milione M, Basturk O, Klimstra DS, Wachtel A, Uccella S, Vicari E, Milesi M, Davì MV, Scarpa A, Sessa F, Capella C, La Rosa S
Am J Surg Pathol 2015 Mar;39(3):374-82. doi: 10.1097/PAS.0000000000000340. PMID: 25353285
Management of euvolemic hyponatremia attributed to SIADH in the hospital setting.
Peri A, Giuliani C
Minerva Endocrinol 2014 Mar;39(1):33-41. PMID: 24513602

Recent systematic reviews

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review.
Abufaraj M, Ramadan R, Alkhatib A
Curr Oncol 2024 Mar 21;31(3):1618-1632. doi: 10.3390/curroncol31030123. PMID: 38534956Free PMC Article
Management of small cell lung cancer complicated with paraneoplastic Cushing's syndrome: a systematic literature review.
Li Y, Li C, Qi X, Yu L, Lin L
Front Endocrinol (Lausanne) 2023;14:1177125. Epub 2023 Oct 17 doi: 10.3389/fendo.2023.1177125. PMID: 37916144Free PMC Article
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature.
Seltzer J, Lucas J, Commins D, Lerner O, Lerner A, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E10. doi: 10.3171/2014.10.FOCUS14685. PMID: 25639312
Ectopic ACTH syndrome.
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...