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DNA Strand Break

MedGen UID:: 209054
•Concept ID:: C0872150
•: Cell or Molecular Dysfunction

Definition

A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDNA Strand Break

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Pathogeneses
    - Pathologic Mutagenesis
      - DNA damage
        DNA Strand Break
        DNA Double Strand Break
        DNA Single Strand Break

Professional guidelines

PubMed

Management of hereditary breast and ovarian cancer.

Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095

Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer.

O'Kane GM, Connor AA, Gallinger S
Trends Mol Med 2017 Dec;23(12):1121-1137. Epub 2017 Nov 10 doi: 10.1016/j.molmed.2017.10.007. PMID: 29133135

Taxane- and epothilone-based chemotherapy: from molecule cargo cytoskeletal logistics to management of castration-resistant prostate carcinoma.

Alberti C
Eur Rev Med Pharmacol Sci 2013 Jun;17(12):1658-64. PMID: 23832735

See all (11)

Recent clinical studies

Etiology

Oxidative stress in metabolic syndrome & its association with DNA-strand break.

Bhutia RD, Sherpa ML, Singh TA, Khandelwal B
Indian J Med Res 2018 Oct;148(4):435-440. doi: 10.4103/ijmr.IJMR_620_17. PMID: 30666006 Free PMC Article

Neurological disorders associated with DNA strand-break processing enzymes.

Jiang B, Glover JN, Weinfeld M
Mech Ageing Dev 2017 Jan;161(Pt A):130-140. Epub 2016 Jul 25 doi: 10.1016/j.mad.2016.07.009. PMID: 27470939 Free PMC Article

Evidence for DNA damage as a biological link between diabetes and cancer.

Lee SC, Chan JC
Chin Med J (Engl) 2015 Jun 5;128(11):1543-8. doi: 10.4103/0366-6999.157693. PMID: 26021514 Free PMC Article

Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress.

Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, Elbert T, Bürkle A, Kolassa IT
Psychother Psychosom 2014;83(5):289-97. Epub 2014 Aug 6 doi: 10.1159/000362739. PMID: 25116690

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Weinfeld M, Mani RS, Abdou I, Aceytuno RD, Glover JN
Trends Biochem Sci 2011 May;36(5):262-71. Epub 2011 Feb 25 doi: 10.1016/j.tibs.2011.01.006. PMID: 21353781 Free PMC Article

See all (62)

Diagnosis

Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells.

Zhang J, Zheng N, Liu J, Li FD, Li SL, Wang JQ
Food Chem Toxicol 2015 Sep;83:54-60. Epub 2015 Jun 5 doi: 10.1016/j.fct.2015.05.020. PMID: 26051350

Tumor hypoxia as a modifier of DNA strand break and cross-link repair.

Chan N, Koch CJ, Bristow RG
Curr Mol Med 2009 May;9(4):401-10. doi: 10.2174/156652409788167050. PMID: 19519397

Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.

Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Bürkle A
Food Chem Toxicol 2002 Aug;40(8):1179-84. doi: 10.1016/s0278-6915(02)00043-1. PMID: 12067581

The comet assay: a comprehensive review.

Fairbairn DW, Olive PL, O'Neill KL
Mutat Res 1995 Feb;339(1):37-59. doi: 10.1016/0165-1110(94)00013-3. PMID: 7877644

Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR.

Pfeifer GP, Drouin R, Holmquist GP
Mutat Res 1993 Jul;288(1):39-46. doi: 10.1016/0027-5107(93)90206-u. PMID: 7686264

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Therapy

Inhibitors of DNA double-strand break repair at the crossroads of cancer therapy and genome editing.

Ray U, Raghavan SC
Biochem Pharmacol 2020 Dec;182:114195. Epub 2020 Aug 13 doi: 10.1016/j.bcp.2020.114195. PMID: 32798465

Perspectives on PARPs in S Phase.

Hanzlikova H, Caldecott KW
Trends Genet 2019 Jun;35(6):412-422. Epub 2019 Apr 26 doi: 10.1016/j.tig.2019.03.008. PMID: 31036342

Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress.

Targeted cancer therapies based on the inhibition of DNA strand break repair.

O'Connor MJ, Martin NM, Smith GC
Oncogene 2007 Dec 10;26(56):7816-24. doi: 10.1038/sj.onc.1210879. PMID: 18066095

DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II).

Jacobi H, Eicke B, Witte I
Free Radic Biol Med 1998 Apr;24(6):972-8. doi: 10.1016/s0891-5849(97)00400-0. PMID: 9607607

See all (53)

Prognosis

Combining inotuzumab ozogamicin with PARP inhibitors olaparib and talazoparib exerts synergistic cytotoxicity in acute lymphoblastic leukemia by inhibiting DNA strand break repair.

Ida N, Okura M, Tanaka S, Hosono N, Yamauchi T
Oncol Rep 2024 Jul;52(1) Epub 2024 May 24 doi: 10.3892/or.2024.8749. PMID: 38785163

Transcriptional roles of PARP1 in cancer.

Schiewer MJ, Knudsen KE
Mol Cancer Res 2014 Aug;12(8):1069-80. Epub 2014 Jun 10 doi: 10.1158/1541-7786.MCR-13-0672. PMID: 24916104 Free PMC Article

Tumor hypoxia as a modifier of DNA strand break and cross-link repair.

Chan N, Koch CJ, Bristow RG
Curr Mol Med 2009 May;9(4):401-10. doi: 10.2174/156652409788167050. PMID: 19519397

DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays.

Van der Schans GP, Paterson MC, Cross WG
Int J Radiat Biol Relat Stud Phys Chem Med 1983 Jul;44(1):75-85. doi: 10.1080/09553008314550881. PMID: 6602790

Induction and repair of DNA damage in normal and ataxia-telangiectasia skin fibroblasts treated with neocarzinostatin.

Shiloh Y, van der Schans GP, Lohman PH, Becker Y
Carcinogenesis 1983;4(7):917-21. doi: 10.1093/carcin/4.7.917. PMID: 6223717

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Clinical prediction guides

DNA damage and arterial hypertension. A systematic review and meta-analysis.

Hazukova R, Rezacova M, Pleskot M, Zadak Z, Cermakova E, Taborsky M
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2024 Mar;168(1):15-24. Epub 2023 Oct 30 doi: 10.5507/bp.2023.044. PMID: 37916467

DNA strand break repair and neurodegeneration.

Rulten SL, Caldecott KW
DNA Repair (Amst) 2013 Aug;12(8):558-67. Epub 2013 May 24 doi: 10.1016/j.dnarep.2013.04.008. PMID: 23712058

Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells.

Garm C, Moreno-Villanueva M, Bürkle A, Petersen I, Bohr VA, Christensen K, Stevnsner T
Aging Cell 2013 Feb;12(1):58-66. Epub 2012 Nov 26 doi: 10.1111/acel.12019. PMID: 23088435 Free PMC Article

DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II).

Jacobi H, Eicke B, Witte I
Free Radic Biol Med 1998 Apr;24(6):972-8. doi: 10.1016/s0891-5849(97)00400-0. PMID: 9607607

Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation.

Masutani M, Nozaki T, Wakabayashi K, Sugimura T
Biochimie 1995;77(6):462-5. doi: 10.1016/0300-9084(96)88161-2. PMID: 7578430

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