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Latent syphilis

MedGen UID:
21056
•Concept ID:
C0039133
•
Disease or Syndrome
Synonyms: Latent Stage Syphilis; Syphilis, Latent; Syphilis, Latent Stage
SNOMED CT: Latent syphilis (444150000)
 
Monarch Initiative: MONDO:0005822

Definition

A stage of syphilis characterized by the serologic evidence of infection by Treponema pallidum without evidence of accompanying signs or symptoms related to the disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLatent syphilis

Professional guidelines

PubMed

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Reexamining syphilis: an update on epidemiology, clinical manifestations, and management.
Kent ME, Romanelli F
Ann Pharmacother 2008 Feb;42(2):226-36. Epub 2008 Jan 22 doi: 10.1345/aph.1K086. PMID: 18212261

Recent clinical studies

Etiology

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Syphilis: a reemerging infection.
Mattei PL, Beachkofsky TM, Gilson RT, Wisco OJ
Am Fam Physician 2012 Sep 1;86(5):433-40. PMID: 22963062
Clinical aspects of adult syphilis.
Read PJ, Donovan B
Intern Med J 2012 Jun;42(6):614-20. doi: 10.1111/j.1445-5994.2012.02814.x. PMID: 22697151

Diagnosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Syphilis.
Merson JR, Shehu M
JAAPA 2019 May;32(5):59-60. doi: 10.1097/01.JAA.0000554749.77547.b1. PMID: 31033717
Syphilis.
Arando Lasagabaster M, Otero Guerra L
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Jun-Jul;37(6):398-404. Epub 2019 Feb 7 doi: 10.1016/j.eimc.2018.12.009. PMID: 30738716
Syphilis--diagnosis and treatment.
Rudolph AH, Duncan WC
Clin Obstet Gynecol 1975 Mar;18(1):163-82. doi: 10.1097/00003081-197503000-00015. PMID: 1091382

Therapy

Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Syphilis.
Merson JR, Shehu M
JAAPA 2019 May;32(5):59-60. doi: 10.1097/01.JAA.0000554749.77547.b1. PMID: 31033717
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Syphilis: a reemerging infection.
Mattei PL, Beachkofsky TM, Gilson RT, Wisco OJ
Am Fam Physician 2012 Sep 1;86(5):433-40. PMID: 22963062

Prognosis

Syphilis.
Peeling RW, Mabey D, Chen XS, Garcia PJ
Lancet 2023 Jul 22;402(10398):336-346. doi: 10.1016/S0140-6736(22)02348-0. PMID: 37481272
Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy.
Girma S, Amogne W
PLoS One 2022;17(7):e0270878. Epub 2022 Jul 12 doi: 10.1371/journal.pone.0270878. PMID: 35819944Free PMC Article
Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Testing for syphilis.
Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

Clinical prediction guides

Clinical and laboratory features in patients with positive syphilis serology presenting with acute ischemic stroke or transient ischemic attack: a prospective cohort study.
Jitpratoom P, Boonyasiri A
BMC Infect Dis 2022 Aug 30;22(1):717. doi: 10.1186/s12879-022-07700-z. PMID: 36042411Free PMC Article
Clinical features associated with neurosyphilis in people living with HIV and late latent syphilis.
Martínez-Ayala P, Quiñonez-Flores A, González-Hernández LA, Ruíz-Herrera VV, Zúñiga-Quiñones S, Alanis-Sánchez GA, Cabrera-Silva RI, Amador-Lara F, Sánchez-Reyes K, Álvarez-Zavala M, Vázquez-Limón JC, Sánchez-Navarro JP, Andrade-Villanueva JF
Int J STD AIDS 2022 Mar;33(4):330-336. Epub 2022 Jan 3 doi: 10.1177/09564624211063091. PMID: 34978502Free PMC Article
Clinical outcomes of syphilis in HIV-negative and HIV-positive MSM: occurrence of repeat syphilis episodes and non-treponemal serology responses.
Nieuwenburg SA, Sprenger RJ, Schim van der Loeff MF, de Vries HJC
Sex Transm Infect 2022 Mar;98(2):95-100. Epub 2021 Feb 19 doi: 10.1136/sextrans-2020-054887. PMID: 33608479
Syphilis infection and epidemiological characteristics in Haidian District, Beijing, China, 2013-2018.
Peng X, Yu S, Wu F, Yang J, Wang Y, Li Y, Zhang G, Lai C, Wei Z, Zhang W
Public Health 2021 Jan;190:62-66. Epub 2020 Dec 21 doi: 10.1016/j.puhe.2020.11.009. PMID: 33360028
Testing for syphilis.
Johnson PC, Farnie MA
Dermatol Clin 1994 Jan;12(1):9-17. PMID: 8143388

Recent systematic reviews

Management of Adult Syphilis: Key Questions to Inform the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.
Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Treatment of syphilis: a systematic review.
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article
Azithromycin versus penicillin G benzathine for early syphilis.
Bai ZG, Wang B, Yang K, Tian JH, Ma B, Liu Y, Jiang L, Gai QY, He X, Li Y
Cochrane Database Syst Rev 2012 Jun 13;(6):CD007270. doi: 10.1002/14651858.CD007270.pub2. PMID: 22696367
Treatment of syphilis in HIV-infected subjects: a systematic review of the literature.
Blank LJ, Rompalo AM, Erbelding EJ, Zenilman JM, Ghanem KG
Sex Transm Infect 2011 Feb;87(1):9-16. Epub 2010 Oct 5 doi: 10.1136/sti.2010.043893. PMID: 20924048

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