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Togaviridae infectious disease

MedGen UID:: 21575
•Concept ID:: C0040361
•: Disease or Syndrome

Synonyms:	Togaviridae disease; Togaviridae infection; Togavirus infections
SNOMED CT:	Disease caused by Togaviridae (33947007); Disease due to Togaviridae (33947007)

Monarch Initiative:	MONDO:0005985

Definition

A viral infection caused by any of the arboviruses of the Togaviridae family. It is transmitted by arthropods. Signs and symptoms include fever, headache, nausea, vomiting, rash, confusion, and seizures. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTogaviridae infectious disease

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Special Category
        Rare Non-Neoplastic Disorder
        Togaviridae infectious disease
        Alphavirus infectious disease
        Chikungunya fever
        Encephalomyelitis, Equine
        Eastern equine encephalitis
        Venezuelan equine encephalitis virus infection
        Western equine encephalitis
        Disease due to Rubivirus
        Rubella
        Congenital rubella syndrome

Professional guidelines

PubMed

Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189

Emergence and treatment of chikungunya arthritis.

Sutaria RB, Amaral JK, Schoen RT
Curr Opin Rheumatol 2018 May;30(3):256-263. doi: 10.1097/BOR.0000000000000486. PMID: 29389830

Chikungunya Arthritis: Implications of Acute and Chronic Inflammation Mechanisms on Disease Management.

Zaid A, Gérardin P, Taylor A, Mostafavi H, Malvy D, Mahalingam S
Arthritis Rheumatol 2018 Apr;70(4):484-495. Epub 2018 Mar 23 doi: 10.1002/art.40403. PMID: 29287308

See all (18)

Recent clinical studies

Etiology

Chikungunya fever.

Bartholomeeusen K, Daniel M, LaBeaud DA, Gasque P, Peeling RW, Stephenson KE, Ng LFP, Ariën KK
Nat Rev Dis Primers 2023 Apr 6;9(1):17. doi: 10.1038/s41572-023-00429-2. PMID: 37024497 Free PMC Article

Chikungunya: risks for travellers.

Simon F, Caumes E, Jelinek T, Lopez-Velez R, Steffen R, Chen LH
J Travel Med 2023 Apr 5;30(2) doi: 10.1093/jtm/taad008. PMID: 36648431 Free PMC Article

Arboviral central nervous system infections.

Schultz JS, Sparks H, Beckham JD
Curr Opin Infect Dis 2021 Jun 1;34(3):264-271. doi: 10.1097/QCO.0000000000000729. PMID: 33899755

Chikungunya virus and autoimmunity.

Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065

Alphaviruses.

Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793

See all (344)

Diagnosis

Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance.

Deng X, Achari A, Federman S, Yu G, Somasekar S, Bártolo I, Yagi S, Mbala-Kingebeni P, Kapetshi J, Ahuka-Mundeke S, Muyembe-Tamfum JJ, Ahmed AA, Ganesh V, Tamhankar M, Patterson JL, Ndembi N, Mbanya D, Kaptue L, McArthur C, Muñoz-Medina JE, Gonzalez-Bonilla CR, López S, Arias CF, Arevalo S, Miller S, Stone M, Busch M, Hsieh K, Messenger S, Wadford DA, Rodgers M, Cloherty G, Faria NR, Thézé J, Pybus OG, Neto Z, Morais J, Taveira N, R Hackett J Jr, Chiu CY
Nat Microbiol 2020 Mar;5(3):443-454. Epub 2020 Jan 13 doi: 10.1038/s41564-019-0637-9. PMID: 31932713 Free PMC Article

Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.

Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189

Chikungunya.

Burnett MW
J Spec Oper Med 2014 Winter;14(4):129-130. doi: 10.55460/8H36-WO5P. PMID: 25399382

Chikungunya virus infection: an overview.

Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Alphaviruses.

Powers AM, Roehrig JT
Methods Mol Biol 2011;665:17-38. doi: 10.1007/978-1-60761-817-1_2. PMID: 21116793

See all (328)

Therapy

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.

de Alwis R, Gan ES, Chen S, Leong YS, Tan HC, Zhang SL, Yau C, Low JGH, Kalimuddin S, Matsuda D, Allen EC, Hartman P, Park KJ, Alayyoubi M, Bhaskaran H, Dukanovic A, Bao Y, Clemente B, Vega J, Roberts S, Gonzalez JA, Sablad M, Yelin R, Taylor W, Tachikawa K, Parker S, Karmali P, Davis J, Sullivan BM, Sullivan SM, Hughes SG, Chivukula P, Ooi EE
Mol Ther 2021 Jun 2;29(6):1970-1983. Epub 2021 Apr 5 doi: 10.1016/j.ymthe.2021.04.001. PMID: 33823303 Free PMC Article

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.

Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107 Free PMC Article

Chikungunya arthritis.

Pathak H, Mohan MC, Ravindran V
Clin Med (Lond) 2019 Sep;19(5):381-385. doi: 10.7861/clinmed.2019-0035. PMID: 31530685 Free PMC Article

Standardization of rubella immunoassays.

Vauloup-Fellous C
J Clin Virol 2018 May;102:34-38. Epub 2018 Feb 15 doi: 10.1016/j.jcv.2018.02.006. PMID: 29486385

Chikungunya virus; an emerging arbovirus in Pakistan.

Ali I, Dasti JI
J Pak Med Assoc 2018 Feb;68(2):252-257. PMID: 29479102

See all (156)

Prognosis

Genetic control of alphavirus pathogenesis.

Baxter VK, Heise MT
Mamm Genome 2018 Aug;29(7-8):408-424. Epub 2018 Aug 27 doi: 10.1007/s00335-018-9776-1. PMID: 30151711 Free PMC Article

Chikungunya virus and autoimmunity.

Tanay A
Curr Opin Rheumatol 2017 Jul;29(4):389-393. doi: 10.1097/BOR.0000000000000396. PMID: 28376065

Ophthalmologic aspects of chikungunya infection.

Martínez-Pulgarín DF, Chowdhury FR, Villamil-Gomez WE, Rodriguez-Morales AJ, Blohm GM, Paniz-Mondolfi AE
Travel Med Infect Dis 2016 Sep-Oct;14(5):451-457. Epub 2016 May 26 doi: 10.1016/j.tmaid.2016.05.008. PMID: 27238905

How great is the threat of chikungunya virus?

Waggoner JJ, Pinsky BA
Expert Rev Anti Infect Ther 2015 Mar;13(3):291-3. Epub 2014 Dec 24 doi: 10.1586/14787210.2015.995634. PMID: 25537007 Free PMC Article

Arthritogenic alphaviruses--an overview.

Suhrbier A, Jaffar-Bandjee MC, Gasque P
Nat Rev Rheumatol 2012 May 8;8(7):420-9. doi: 10.1038/nrrheum.2012.64. PMID: 22565316

See all (165)

Clinical prediction guides

Clinical Manifestations and Outcomes in Disease-Modifying Antirheumatic Drug-Naive Adult Patients with Chronic Chikungunya Arthritis.

Medina-Cintrón N, Martínez I, Pérez-Ríos N, Berríos-López Y, Vilá LM
Am J Trop Med Hyg 2021 Mar 8;104(5):1741-1746. doi: 10.4269/ajtmh.20-1573. PMID: 33684065 Free PMC Article

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.

Blakney AK, McKay PF, Bouton CR, Hu K, Samnuan K, Shattock RJ
Mol Ther 2021 Mar 3;29(3):1174-1185. Epub 2020 Dec 21 doi: 10.1016/j.ymthe.2020.11.011. PMID: 33352107 Free PMC Article

How great is the threat of chikungunya virus?

Waggoner JJ, Pinsky BA
Expert Rev Anti Infect Ther 2015 Mar;13(3):291-3. Epub 2014 Dec 24 doi: 10.1586/14787210.2015.995634. PMID: 25537007 Free PMC Article

Chikungunya virus infection: an overview.

Caglioti C, Lalle E, Castilletti C, Carletti F, Capobianchi MR, Bordi L
New Microbiol 2013 Jul;36(3):211-27. Epub 2013 Jun 30 PMID: 23912863

Chikungunya virus: host pathogen interaction.

Singh SK, Unni SK
Rev Med Virol 2011 Mar;21(2):78-88. Epub 2011 Mar 15 doi: 10.1002/rmv.681. PMID: 21412934

See all (233)

Recent systematic reviews

Associations between temperature and Ross river virus infection: A systematic review and meta-analysis of epidemiological evidence.

Damtew YT, Tong M, Varghese BM, Hansen A, Liu J, Dear K, Zhang Y, Morgan G, Driscoll T, Capon T, Bi P
Acta Trop 2022 Jul;231:106454. Epub 2022 Apr 9 doi: 10.1016/j.actatropica.2022.106454. PMID: 35405101

Sexual Transmission of Arboviruses: A Systematic Review.

Blitvich BJ, Magalhaes T, Laredo-Tiscareño SV, Foy BD
Viruses 2020 Aug 25;12(9) doi: 10.3390/v12090933. PMID: 32854298 Free PMC Article

Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.

Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD
PLoS Negl Trop Dis 2018 Jun;12(6):e0006510. Epub 2018 Jun 13 doi: 10.1371/journal.pntd.0006510. PMID: 29897898 Free PMC Article

The neurological complications of chikungunya virus: A systematic review.

Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T
Rev Med Virol 2018 May;28(3):e1978. Epub 2018 Apr 19 doi: 10.1002/rmv.1978. PMID: 29671914 Free PMC Article

Prevalence of chronic comorbidities in chikungunya: A systematic review and meta-analysis.

Badawi A, Ryoo SG, Vasileva D, Yaghoubi S
Int J Infect Dis 2018 Feb;67:107-113. Epub 2017 Dec 20 doi: 10.1016/j.ijid.2017.12.018. PMID: 29277382 Free PMC Article

See all (21)

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Togaviridae infectious disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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