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Polymorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
220971
Concept ID:
C1301361
Neoplastic Process
Synonyms: Polymorphic B-Cell Lymphoma; Polymorphic B-Cell Post-Transplant Lymphoproliferative Disorder; Polymorphic lymphoproliferative disorder following transplant; Polymorphic post-transplant lymphoproliferative disorder; Polymorphic PTLD; Post-transplant lymphoproliferative disorder, polymorphic
SNOMED CT: Post-transplant lymphoproliferative disorder, polymorphic (397351004); Polymorphic post-transplant lymphoproliferative disorder (762316003); Polymorphic lymphoproliferative disorder following transplant (762316003)

Definition

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some cases, reduction of the immunosuppression therapy may lead to regression of the lesions. In other cases the lesions may progress to lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolymorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Füreder A, Kropshofer G, Benesch M, Dworzak M, Greil S, Huber WD, Hubmann H, Lawitschka A, Mann G, Michel-Behnke I, Müller-Sacherer T, Pichler H, Simonitsch-Klupp I, Schwinger W, Szepfalusi Z, Crazzolara R, Attarbaschi A; Austrian Society of Pediatric Hematology and Oncology
Cancer Rep (Hoboken) 2021 Oct;4(5):e1375. Epub 2021 Mar 23 doi: 10.1002/cnr2.1375. PMID: 33755341Free PMC Article
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Recent clinical studies

Etiology

Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Shahid S, Rossi C, Vyas P, Bollard C, Dave H
Pediatr Hematol Oncol 2019 Aug;36(5):309-316. Epub 2019 Jul 17 doi: 10.1080/08880018.2019.1637982. PMID: 31314679
Cesarman E
Cancer Lett 2011 Jun 28;305(2):163-74. Epub 2011 Apr 13 doi: 10.1016/j.canlet.2011.03.003. PMID: 21493001Free PMC Article
Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

Diagnosis

Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Chen KY, Lin CY, Kuo TT, Shih LY, Chang CH, Chen WT, Yang CY
Pediatr Dermatol 2019 Sep;36(5):681-685. Epub 2019 Jun 18 doi: 10.1111/pde.13903. PMID: 31215060
Dunn C, Nguyen HP, Patel V, Barker HS, Diwan AH, Yared M, Elghetany T, Restrepo A, Dao H
J Cutan Pathol 2019 May;46(5):358-362. Epub 2019 Feb 27 doi: 10.1111/cup.13427. PMID: 30672006
Itonaga H, Kato T, Fujioka M, Taguchi M, Taniguchi H, Imaizumi Y, Yoshida S, Miyoshi H, Moriuchi Y, Ohshima K, Miyazaki Y
Intern Med 2017;56(14):1873-1877. Epub 2017 Jul 15 doi: 10.2169/internalmedicine.56.7938. PMID: 28717085Free PMC Article
Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

Therapy

Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Shahid S, Rossi C, Vyas P, Bollard C, Dave H
Pediatr Hematol Oncol 2019 Aug;36(5):309-316. Epub 2019 Jul 17 doi: 10.1080/08880018.2019.1637982. PMID: 31314679
Chen KY, Lin CY, Kuo TT, Shih LY, Chang CH, Chen WT, Yang CY
Pediatr Dermatol 2019 Sep;36(5):681-685. Epub 2019 Jun 18 doi: 10.1111/pde.13903. PMID: 31215060
Sun X, Peterson LC, Gong Y, Traynor AE, Nelson BP
Mod Pathol 2004 Apr;17(4):389-94. doi: 10.1038/modpathol.3800080. PMID: 14976525

Prognosis

Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Sun X, Peterson LC, Gong Y, Traynor AE, Nelson BP
Mod Pathol 2004 Apr;17(4):389-94. doi: 10.1038/modpathol.3800080. PMID: 14976525

Clinical prediction guides

Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

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