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Intermediate uveitis

MedGen UID:
22596
•Concept ID:
C0042166
•
Disease or Syndrome
Synonyms: Chronic Cyclitis; Cyclitis, Chronic; Intermediate Uveitis; Uveitis, Intermediate
SNOMED CT: Peripheral uveitis (314429009); Peripheral uveoretinitis (314429009); Intermediate uveitis (314429009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0012124
Monarch Initiative: MONDO:0006806
Orphanet: ORPHA279914

Definition

Inflammation of the uveal tract in which the primary site of inflammation is the vitreous. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntermediate uveitis
Follow this link to review classifications for Intermediate uveitis in Orphanet.

Professional guidelines

PubMed

Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Advancements in the management of uveitis.
Schwartzman S
Best Pract Res Clin Rheumatol 2016 Apr;30(2):304-315. Epub 2016 Oct 31 doi: 10.1016/j.berh.2016.07.005. PMID: 27886802
Differential diagnosis of behçet uveitis.
Tugal-Tutkun I, Gupta V, Cunningham ET
Ocul Immunol Inflamm 2013 Oct;21(5):337-50. Epub 2013 Jun 3 doi: 10.3109/09273948.2013.795228. PMID: 23730816

Recent clinical studies

Etiology

Epidemiology of Pediatric Uveitis.
Gentile P, Ragusa E, Bolletta E, De Simone L, Gozzi F, Cappella M, Fastiggi M, De Fanti A, Cimino L
Ocul Immunol Inflamm 2023 Dec;31(10):2050-2059. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2271988. PMID: 37922466
Intermediate Uveitis: A Review.
Teo AYT, Betzler BK, Hua KLQ, Chen EJ, Gupta V, Agrawal R
Ocul Immunol Inflamm 2023 Jul;31(5):1041-1060. Epub 2022 Jun 27 doi: 10.1080/09273948.2022.2070503. PMID: 35759636
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop.
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. PMID: 16196117Free PMC Article

Diagnosis

Epidemiology of Pediatric Uveitis.
Gentile P, Ragusa E, Bolletta E, De Simone L, Gozzi F, Cappella M, Fastiggi M, De Fanti A, Cimino L
Ocul Immunol Inflamm 2023 Dec;31(10):2050-2059. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2271988. PMID: 37922466
Intermediate Uveitis: A Review.
Teo AYT, Betzler BK, Hua KLQ, Chen EJ, Gupta V, Agrawal R
Ocul Immunol Inflamm 2023 Jul;31(5):1041-1060. Epub 2022 Jun 27 doi: 10.1080/09273948.2022.2070503. PMID: 35759636
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Intermediate uveitis.
Babu BM, Rathinam SR
Indian J Ophthalmol 2010 Jan-Feb;58(1):21-7. doi: 10.4103/0301-4738.58469. PMID: 20029143Free PMC Article
Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop.
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. PMID: 16196117Free PMC Article

Therapy

Sarcoid Uveitis: An Intriguing Challenger.
Allegri P, Olivari S, Rissotto F, Rissotto R
Medicina (Kaunas) 2022 Jul 4;58(7) doi: 10.3390/medicina58070898. PMID: 35888617Free PMC Article
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Immunosuppression for the Uveitides.
Jabs DA
Ophthalmology 2018 Feb;125(2):193-202. Epub 2017 Sep 20 doi: 10.1016/j.ophtha.2017.08.007. PMID: 28942074Free PMC Article
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Intermediate uveitis.
Babu BM, Rathinam SR
Indian J Ophthalmol 2010 Jan-Feb;58(1):21-7. doi: 10.4103/0301-4738.58469. PMID: 20029143Free PMC Article

Prognosis

Demyelinating plaque-associated uveitis.
Hedayatfar A, Anvari P, Herbort CP Jr, Chee SP
Graefes Arch Clin Exp Ophthalmol 2024 Feb;262(2):575-582. Epub 2023 Oct 19 doi: 10.1007/s00417-023-06270-3. PMID: 37855958
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Intermediate uveitis.
Babu BM, Rathinam SR
Indian J Ophthalmol 2010 Jan-Feb;58(1):21-7. doi: 10.4103/0301-4738.58469. PMID: 20029143Free PMC Article
Intermediate uveitis.
Bonfioli AA, Damico FM, Curi AL, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):147-54. doi: 10.1080/08820530500232035. PMID: 16282148
Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop.
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. PMID: 16196117Free PMC Article

Clinical prediction guides

Demyelinating plaque-associated uveitis.
Hedayatfar A, Anvari P, Herbort CP Jr, Chee SP
Graefes Arch Clin Exp Ophthalmol 2024 Feb;262(2):575-582. Epub 2023 Oct 19 doi: 10.1007/s00417-023-06270-3. PMID: 37855958
Pediatric Pars Planitis: A Review.
Khochtali S, Ozdal P, AlBloushi AF, Nabi W, Khairallah M
Ocul Immunol Inflamm 2023 Dec;31(10):1915-1929. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2279683. PMID: 37976519
Uveitis in children: Epidemiological, clinical and prognostic characteristics.
Rodier-Bonifas C, Rochet E, Seve P, Duquesne A, Nguyen AM, Denis P, Kodjikian L, Mathis T
J Fr Ophtalmol 2023 Feb;46(2):163-172. Epub 2023 Jan 13 doi: 10.1016/j.jfo.2022.08.005. PMID: 36642594
Demographic and Clinical Features of Pediatric Uveitis in Israel.
Habot-Wilner Z, Tiosano L, Sanchez JM, Shulman S, Barequet D, Rahat O, Amarilyo G, Amer R
Ocul Immunol Inflamm 2020;28(1):43-53. Epub 2018 Oct 17 doi: 10.1080/09273948.2018.1535079. PMID: 30332547
Immunopathogenic Background of Pars Planitis.
Przeździecka-Dołyk J, Węgrzyn A, Turno-Kręcicka A, Misiuk-Hojło M
Arch Immunol Ther Exp (Warsz) 2016 Apr;64(2):127-37. Epub 2015 Oct 5 doi: 10.1007/s00005-015-0361-y. PMID: 26438050Free PMC Article

Recent systematic reviews

Effectiveness and safety of tenofovir alafenamide in children and adolescents living with HIV: a systematic review.
O'Rourke J, Townsend CL, Milanzi E, Collins IJ, Castro H, Judd A, Vicari M, Jesson J, Leroy V, Penazzato M, Renaud F
J Int AIDS Soc 2023 Feb;26(2):e26037. doi: 10.1002/jia2.26037. PMID: 36823283Free PMC Article
A Systematic Review of Clinical Trials in Uveitis: Lessons Learned.
Lobo-Chan AM, Joltikov K, Haseeb A, Mehta SD
Ophthalmic Epidemiol 2023 Oct;30(5):445-452. Epub 2022 Oct 6 doi: 10.1080/09286586.2022.2131837. PMID: 36204817Free PMC Article
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults.
Squires H, Poku E, Bermejo I, Cooper K, Stevens J, Hamilton J, Wong R, Denniston A, Pearce I, Quhill F
Health Technol Assess 2017 Nov;21(68):1-170. doi: 10.3310/hta21680. PMID: 29183563Free PMC Article
Corticosteroid implants for chronic non-infectious uveitis.
Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD010469. doi: 10.1002/14651858.CD010469.pub2. PMID: 26866343Free PMC Article
Uveitis: a global perspective.
Chang JH, Wakefield D
Ocul Immunol Inflamm 2002 Dec;10(4):263-79. doi: 10.1076/ocii.10.4.263.15592. PMID: 12854035

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