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Hepatic insufficiency

MedGen UID:
227013
•Concept ID:
C1306571
•
Pathologic Function
Synonyms: Hepatic Insufficiency; Insufficiency, Hepatic; Insufficiency, Liver; Liver Insufficiency
SNOMED CT: Hepatic insufficiency (59927004)

Definition

The inability of the liver to perform its normal synthetic and metabolic functions. [from NCI]

Professional guidelines

PubMed

Treatment of Coagulopathy Related to Hepatic Insufficiency.
Barton CA
Crit Care Med 2016 Oct;44(10):1927-33. doi: 10.1097/CCM.0000000000001998. PMID: 27635482
The Role of Sarcopenia and Frailty in Hepatic Encephalopathy Management.
Lucero C, Verna EC
Clin Liver Dis 2015 Aug;19(3):507-28. doi: 10.1016/j.cld.2015.04.003. PMID: 26195205
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Recent clinical studies

Etiology

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
LaPlante KL, Dhand A, Wright K, Lauterio M
Ann Med 2022 Dec;54(1):1686-1700. doi: 10.1080/07853890.2022.2085881. PMID: 35723082Free PMC Article
Clinical Pharmacokinetics of Daptomycin.
Gregoire N, Chauzy A, Buyck J, Rammaert B, Couet W, Marchand S
Clin Pharmacokinet 2021 Mar;60(3):271-281. Epub 2020 Dec 14 doi: 10.1007/s40262-020-00968-x. PMID: 33313994
Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations.
Wanleenuwat P, Suntharampillai N, Iwanowski P
Seizure 2020 Oct;81:167-174. Epub 2020 Aug 14 doi: 10.1016/j.seizure.2020.08.012. PMID: 32827980
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722

Diagnosis

Hepatic Injury in Patients With COVID-19.
Kullar R, Patel AP, Saab S
J Clin Gastroenterol 2020 Nov/Dec;54(10):841-849. doi: 10.1097/MCG.0000000000001432. PMID: 32976196
Gastrointestinal, Pancreatic, and Hepatic Manifestations of Cystic Fibrosis in the Newborn.
Galante G, Freeman AJ
Neoreviews 2019 Jan;20(1):e12-e24. doi: 10.1542/neo.20-1-e12. PMID: 31261070
Diagnosis of Budd-Chiari syndrome.
Van Wettere M, Bruno O, Rautou PE, Vilgrain V, Ronot M
Abdom Radiol (NY) 2018 Aug;43(8):1896-1907. doi: 10.1007/s00261-017-1447-2. PMID: 29285598
Colorectal liver metastases.
Tzeng CW, Aloia TA
J Gastrointest Surg 2013 Jan;17(1):195-201; quiz p.201-2. Epub 2012 Oct 3 doi: 10.1007/s11605-012-2022-3. PMID: 23054896
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Therapy

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
LaPlante KL, Dhand A, Wright K, Lauterio M
Ann Med 2022 Dec;54(1):1686-1700. doi: 10.1080/07853890.2022.2085881. PMID: 35723082Free PMC Article
Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations.
Wanleenuwat P, Suntharampillai N, Iwanowski P
Seizure 2020 Oct;81:167-174. Epub 2020 Aug 14 doi: 10.1016/j.seizure.2020.08.012. PMID: 32827980
Dose recommendations for anticancer drugs in patients with renal or hepatic impairment.
Krens SD, Lassche G, Jansman FGA, Desar IME, Lankheet NAG, Burger DM, van Herpen CML, van Erp NP
Lancet Oncol 2019 Apr;20(4):e200-e207. doi: 10.1016/S1470-2045(19)30145-7. PMID: 30942181
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Prognosis

Hepatic Injury in Patients With COVID-19.
Kullar R, Patel AP, Saab S
J Clin Gastroenterol 2020 Nov/Dec;54(10):841-849. doi: 10.1097/MCG.0000000000001432. PMID: 32976196
Gastrointestinal, Pancreatic, and Hepatic Manifestations of Cystic Fibrosis in the Newborn.
Galante G, Freeman AJ
Neoreviews 2019 Jan;20(1):e12-e24. doi: 10.1542/neo.20-1-e12. PMID: 31261070
Shear wave liver elastography.
Barr RG
Abdom Radiol (NY) 2018 Apr;43(4):800-807. doi: 10.1007/s00261-017-1375-1. PMID: 29116341
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Clinical prediction guides

Efficacy and safety of caspofungin for patients with hepatic insufficiency.
Ran X, Wang P, Zhang A, Tang B
BMC Infect Dis 2022 Jun 20;22(1):560. doi: 10.1186/s12879-022-07527-8. PMID: 35725403Free PMC Article
Clinical Pharmacokinetics of Daptomycin.
Gregoire N, Chauzy A, Buyck J, Rammaert B, Couet W, Marchand S
Clin Pharmacokinet 2021 Mar;60(3):271-281. Epub 2020 Dec 14 doi: 10.1007/s40262-020-00968-x. PMID: 33313994
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, Cohen V, Filk N, Smith A, Huang F, Rockoff B, Homel P, Fromm C
Ann Emerg Med 2017 Aug;70(2):177-184. Epub 2016 Dec 16 doi: 10.1016/j.annemergmed.2016.10.014. PMID: 27993418
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722

Recent systematic reviews

Clinical outcomes of patients with hepatic insufficiency undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis.
Jiang W, Cheng Z, Tu S, Wang X, Xiang C, Zhou W, Chen L
BMC Cardiovasc Disord 2022 Feb 23;22(1):67. doi: 10.1186/s12872-022-02510-2. PMID: 35196988Free PMC Article
A systematic review and meta-analysis of the utility of repeated versus single hepatic resection for colorectal cancer liver metastases.
Wurster EF, Tenckhoff S, Probst P, Jensen K, Dölger E, Knebel P, Diener MK, Büchler MW, Ulrich A
HPB (Oxford) 2017 Jun;19(6):491-497. Epub 2017 Mar 25 doi: 10.1016/j.hpb.2017.02.440. PMID: 28347640
The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.
Li H, Guo Y, Yang Z, Roy M, Guo Q
Burns 2016 Jun;42(4):717-27. Epub 2015 Oct 9 doi: 10.1016/j.burns.2015.08.023. PMID: 26454425
Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis: a systematic review.
de Goede B, Klitsie PJ, Lange JF, Metselaar HJ, Kazemier G
Best Pract Res Clin Gastroenterol 2012 Feb;26(1):47-59. doi: 10.1016/j.bpg.2012.01.010. PMID: 22482525
Radionuclide therapy in neuroendocrine tumours: a systematic review.
Gulenchyn KY, Yao X, Asa SL, Singh S, Law C
Clin Oncol (R Coll Radiol) 2012 May;24(4):294-308. Epub 2012 Jan 4 doi: 10.1016/j.clon.2011.12.003. PMID: 22221516

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