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Alcohol-Related Esophageal Squamous Cell Carcinoma

MedGen UID:
231048
•Concept ID:
C1332227
•
Neoplastic Process
Synonym: Alcohol-Related Esophageal Carcinoma

Definition

An esophageal carcinoma that results from alcohol consumption. The alcohol-related esophageal carcinomas are always of squamous cell type. There is no association between alcohol consumption and esophageal adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcohol-Related Esophageal Squamous Cell Carcinoma

Professional guidelines

PubMed

Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males.
Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H
Cancer Epidemiol Biomarkers Prev 1996 Feb;5(2):99-102. PMID: 8850269

Recent clinical studies

Etiology

ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment.
Flashner S, Shimonosono M, Tomita Y, Matsuura N, Ohashi S, Muto M, Klein-Szanto AJ, Alan Diehl J, Chen CH, Mochly-Rosen D, Weinberg KI, Nakagawa H
Carcinogenesis 2024 Feb 12;45(1-2):95-106. doi: 10.1093/carcin/bgad085. PMID: 37978873Free PMC Article
Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.
Zhang B, Peng YH, Luo Y, Hong CQ, Lin YW, Zhang YL, Xu YW, Su XF, Wu FC
Cancer Med 2023 Oct;12(20):20437-20449. Epub 2023 Oct 5 doi: 10.1002/cam4.6610. PMID: 37795758Free PMC Article
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180
Menopausal hormone therapy and the risk of esophageal and gastric cancer.
Brusselaers N, Maret-Ouda J, Konings P, El-Serag HB, Lagergren J
Int J Cancer 2017 Apr 1;140(7):1693-1699. Epub 2017 Jan 6 doi: 10.1002/ijc.30588. PMID: 28006838
Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility.
Hori H, Kawano T, Endo M, Yuasa Y
J Clin Gastroenterol 1997 Dec;25(4):568-75. doi: 10.1097/00004836-199712000-00003. PMID: 9451664

Diagnosis

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.
Ko JM, Guo C, Liu C, Ning L, Dai W, Tao L, Lo AW, Wong CW, Wong IY, Chan FS, Wong CL, Chan KK, Law TT, Lee NP, Liu Z, Jiang H, Li Z, Law S, Lung ML
Br J Cancer 2022 Dec;127(12):2166-2174. Epub 2022 Oct 19 doi: 10.1038/s41416-022-01995-0. PMID: 36261585Free PMC Article
A superficial esophageal cancer in an epiphrenic diverticulum treated by endoscopic submucosal dissection.
Fu K, Jin P, He Y, Suzuki M, Sheng J
BMC Gastroenterol 2017 Aug 7;17(1):94. doi: 10.1186/s12876-017-0649-y. PMID: 28784105Free PMC Article
Recent trends in incidence rates for selected alcohol-related cancers in the United States.
Polednak AP
Alcohol Alcohol 2005 May-Jun;40(3):234-8. Epub 2005 Mar 29 doi: 10.1093/alcalc/agh150. PMID: 15797879
Rapid development of esophageal squamous cell carcinoma after liver transplantation for alcohol-induced cirrhosis.
Kenngott S, Gerbes AL, Schauer R, Bilzer M
Transpl Int 2003 Sep;16(9):639-41. Epub 2003 May 27 doi: 10.1007/s00147-003-0600-8. PMID: 12768231

Therapy

Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.
Zhang B, Peng YH, Luo Y, Hong CQ, Lin YW, Zhang YL, Xu YW, Su XF, Wu FC
Cancer Med 2023 Oct;12(20):20437-20449. Epub 2023 Oct 5 doi: 10.1002/cam4.6610. PMID: 37795758Free PMC Article
Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.
Ko JM, Guo C, Liu C, Ning L, Dai W, Tao L, Lo AW, Wong CW, Wong IY, Chan FS, Wong CL, Chan KK, Law TT, Lee NP, Liu Z, Jiang H, Li Z, Law S, Lung ML
Br J Cancer 2022 Dec;127(12):2166-2174. Epub 2022 Oct 19 doi: 10.1038/s41416-022-01995-0. PMID: 36261585Free PMC Article
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180
Menopausal hormone therapy and the risk of esophageal and gastric cancer.
Brusselaers N, Maret-Ouda J, Konings P, El-Serag HB, Lagergren J
Int J Cancer 2017 Apr 1;140(7):1693-1699. Epub 2017 Jan 6 doi: 10.1002/ijc.30588. PMID: 28006838
Tobacco and alcohol as risk factors for oesophageal cancer in a high incidence area in South Africa.
Sewram V, Sitas F, O'Connell D, Myers J
Cancer Epidemiol 2016 Apr;41:113-21. Epub 2016 Feb 20 doi: 10.1016/j.canep.2016.02.001. PMID: 26900781

Prognosis

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.
Ko JM, Guo C, Liu C, Ning L, Dai W, Tao L, Lo AW, Wong CW, Wong IY, Chan FS, Wong CL, Chan KK, Law TT, Lee NP, Liu Z, Jiang H, Li Z, Law S, Lung ML
Br J Cancer 2022 Dec;127(12):2166-2174. Epub 2022 Oct 19 doi: 10.1038/s41416-022-01995-0. PMID: 36261585Free PMC Article
Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract.
Harada H, Shinohara S, Takebayashi S, Kikuchi M, Fujiwara K, Michida T, Yamamoto R, Hayashi K, Saida K, Naito Y
Jpn J Clin Oncol 2017 Dec 1;47(12):1123-1128. doi: 10.1093/jjco/hyx150. PMID: 29136221
Tobacco and alcohol as risk factors for oesophageal cancer in a high incidence area in South Africa.
Sewram V, Sitas F, O'Connell D, Myers J
Cancer Epidemiol 2016 Apr;41:113-21. Epub 2016 Feb 20 doi: 10.1016/j.canep.2016.02.001. PMID: 26900781
Risk of oesophageal cancer among patients previously hospitalised with eating disorder.
Brewster DH, Nowell SL, Clark DN
Cancer Epidemiol 2015 Jun;39(3):313-20. Epub 2015 Mar 11 doi: 10.1016/j.canep.2015.02.009. PMID: 25769223Free PMC Article
Recent trends in incidence rates for selected alcohol-related cancers in the United States.
Polednak AP
Alcohol Alcohol 2005 May-Jun;40(3):234-8. Epub 2005 Mar 29 doi: 10.1093/alcalc/agh150. PMID: 15797879

Clinical prediction guides

FANCD2 limits acetaldehyde-induced genomic instability during DNA replication in esophageal keratinocytes.
Peake JD, Noguchi C, Lin B, Theriault A, O'Connor M, Sheth S, Tanaka K, Nakagawa H, Noguchi E
Mol Oncol 2021 Nov;15(11):3109-3124. Epub 2021 Aug 8 doi: 10.1002/1878-0261.13072. PMID: 34328261Free PMC Article
Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract.
Harada H, Shinohara S, Takebayashi S, Kikuchi M, Fujiwara K, Michida T, Yamamoto R, Hayashi K, Saida K, Naito Y
Jpn J Clin Oncol 2017 Dec 1;47(12):1123-1128. doi: 10.1093/jjco/hyx150. PMID: 29136221
Tobacco and alcohol as risk factors for oesophageal cancer in a high incidence area in South Africa.
Sewram V, Sitas F, O'Connell D, Myers J
Cancer Epidemiol 2016 Apr;41:113-21. Epub 2016 Feb 20 doi: 10.1016/j.canep.2016.02.001. PMID: 26900781
Rapid development of esophageal squamous cell carcinoma after liver transplantation for alcohol-induced cirrhosis.
Kenngott S, Gerbes AL, Schauer R, Bilzer M
Transpl Int 2003 Sep;16(9):639-41. Epub 2003 May 27 doi: 10.1007/s00147-003-0600-8. PMID: 12768231
Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer.
Muto M, Nakane M, Hitomi Y, Yoshida S, Sasaki S, Ohtsu A, Yoshida S, Ebihara S, Esumi H
Carcinogenesis 2002 Oct;23(10):1759-65. doi: 10.1093/carcin/23.10.1759. PMID: 12376487

Recent systematic reviews

Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180

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