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Benign Nipple Neoplasm

MedGen UID:
231940
•Concept ID:
C1332519
•
Neoplastic Process
Synonyms: Benign Neoplasm of Nipple; Benign Neoplasm of the Nipple; Benign Nipple Tumor; Benign Tumor of Nipple; Benign Tumor of the Nipple

Definition

A neoplasm that arises from the nipple and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Nipple Neoplasm

Professional guidelines

PubMed

Management of breast complaints and high-risk lesions.
Pleasant V
Best Pract Res Clin Obstet Gynaecol 2022 Sep;83:46-59. Epub 2022 Apr 4 doi: 10.1016/j.bpobgyn.2022.03.017. PMID: 35570155
Challenges in the Management of Breast Conditions During Lactation.
Mitchell KB, Johnson HM
Obstet Gynecol Clin North Am 2022 Mar;49(1):35-55. doi: 10.1016/j.ogc.2021.11.002. PMID: 35168772
Differential diagnosis of benign and malignant male breast lesions in mammography.
Huang Y, Xiao Q, Sun Y, Li Q, Wang S, Gu Y
Eur J Radiol 2020 Nov;132:109339. Epub 2020 Oct 9 doi: 10.1016/j.ejrad.2020.109339. PMID: 33080548

Recent clinical studies

Etiology

Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Management of breast complaints and high-risk lesions.
Pleasant V
Best Pract Res Clin Obstet Gynaecol 2022 Sep;83:46-59. Epub 2022 Apr 4 doi: 10.1016/j.bpobgyn.2022.03.017. PMID: 35570155
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
Clinical and sonographic features of nipple lesions.
Cai S, Wang H, Zhu Q, Li J, Sun Q, Jiang Y
Medicine (Baltimore) 2020 Apr;99(15):e19728. doi: 10.1097/MD.0000000000019728. PMID: 32282731Free PMC Article
Newborn skin: Part II. Birthmarks.
McLaughlin MR, O'Connor NR, Ham P
Am Fam Physician 2008 Jan 1;77(1):56-60. PMID: 18236823

Diagnosis

Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Benign Breast Disorders.
Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773
The microbiome and breast cancer: a review.
Chen J, Douglass J, Prasath V, Neace M, Atrchian S, Manjili MH, Shokouhi S, Habibi M
Breast Cancer Res Treat 2019 Dec;178(3):493-496. Epub 2019 Aug 27 doi: 10.1007/s10549-019-05407-5. PMID: 31456069
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Benign Breast Conditions.
Bodine AM, Holahan B, Mixon A
J Am Osteopath Assoc 2017 Dec 1;117(12):755-760. doi: 10.7556/jaoa.2017.147. PMID: 29181518

Therapy

Surgical and Oncologic Outcomes of Robotic and Conventional Nipple-Sparing Mastectomy with Immediate Reconstruction: International Multicenter Pooled Data Analysis.
Park HS, Lee J, Lai HW, Park JM, Ryu JM, Lee JE, Kim JY, Marrazzo E, De Scalzi AM, Corso G, Montemurro F, Gazzetta G, Pozzi G, Toesca A
Ann Surg Oncol 2022 Oct;29(11):6646-6657. Epub 2022 May 18 doi: 10.1245/s10434-022-11865-x. PMID: 35583693
Inflammatory breast cancer: early recognition and diagnosis is critical.
Hester RH, Hortobagyi GN, Lim B
Am J Obstet Gynecol 2021 Oct;225(4):392-396. Epub 2021 Apr 20 doi: 10.1016/j.ajog.2021.04.217. PMID: 33845027
Mammary ductoscopy in the current management of breast disease.
Tang SS, Twelves DJ, Isacke CM, Gui GP
Surg Endosc 2011 Jun;25(6):1712-22. Epub 2010 Dec 18 doi: 10.1007/s00464-010-1465-4. PMID: 21170661
Benign breast disease.
Hamed H, Fentiman IS
Int J Clin Pract 2001 Sep;55(7):461-4. PMID: 11594256
Breast adenomas.
Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

Prognosis

Clinical and sonographic features of nipple lesions.
Cai S, Wang H, Zhu Q, Li J, Sun Q, Jiang Y
Medicine (Baltimore) 2020 Apr;99(15):e19728. doi: 10.1097/MD.0000000000019728. PMID: 32282731Free PMC Article
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.
Parida S, Sharma D
Biochim Biophys Acta Rev Cancer 2019 Apr;1871(2):392-405. Epub 2019 Apr 11 doi: 10.1016/j.bbcan.2019.04.001. PMID: 30981803Free PMC Article
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Breast metastases from extramammary malignancies: multimodality imaging aspects.
Bitencourt AGV, Gama RRM, Graziano L, Negrão EMS, Sabino SMPS, Watanabe AHU, Guatelli CS, Souza JA, Mauad EC, Marques EF
Br J Radiol 2017 Aug;90(1077):20170197. Epub 2017 May 25 doi: 10.1259/bjr.20170197. PMID: 28485985Free PMC Article
Newborn skin: Part II. Birthmarks.
McLaughlin MR, O'Connor NR, Ham P
Am Fam Physician 2008 Jan 1;77(1):56-60. PMID: 18236823

Clinical prediction guides

Surgical and Oncologic Outcomes of Robotic and Conventional Nipple-Sparing Mastectomy with Immediate Reconstruction: International Multicenter Pooled Data Analysis.
Park HS, Lee J, Lai HW, Park JM, Ryu JM, Lee JE, Kim JY, Marrazzo E, De Scalzi AM, Corso G, Montemurro F, Gazzetta G, Pozzi G, Toesca A
Ann Surg Oncol 2022 Oct;29(11):6646-6657. Epub 2022 May 18 doi: 10.1245/s10434-022-11865-x. PMID: 35583693
Is the skin microbiota a modifiable risk factor for breast disease?: A systematic review.
Wang K, Nakano K, Naderi N, Bajaj-Elliott M, Mosahebi A
Breast 2021 Oct;59:279-285. Epub 2021 Jul 21 doi: 10.1016/j.breast.2021.07.014. PMID: 34329949Free PMC Article
Clinical and sonographic features of nipple lesions.
Cai S, Wang H, Zhu Q, Li J, Sun Q, Jiang Y
Medicine (Baltimore) 2020 Apr;99(15):e19728. doi: 10.1097/MD.0000000000019728. PMID: 32282731Free PMC Article
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.
Parida S, Sharma D
Biochim Biophys Acta Rev Cancer 2019 Apr;1871(2):392-405. Epub 2019 Apr 11 doi: 10.1016/j.bbcan.2019.04.001. PMID: 30981803Free PMC Article
Newborn skin: Part II. Birthmarks.
McLaughlin MR, O'Connor NR, Ham P
Am Fam Physician 2008 Jan 1;77(1):56-60. PMID: 18236823

Recent systematic reviews

Role of duct excision surgery in the treatment of pathological nipple discharge and detection of breast carcinoma: systematic review.
Makineli S, van Wijnbergen JWM, Vriens MR, van Diest PJ, Witkamp AJ
BJS Open 2023 Jul 10;7(4) doi: 10.1093/bjsopen/zrad066. PMID: 37459137Free PMC Article
Diagnostic Accuracy of Nipple Discharge Fluid Cytology: A Meta-Analysis and Systematic Review of the Literature.
Jiwa N, Kumar S, Gandhewar R, Chauhan H, Nagarajan V, Wright C, Hadjiminas D, Takats Z, Ashrafian H, Leff DR
Ann Surg Oncol 2022 Mar;29(3):1774-1786. Epub 2021 Nov 27 doi: 10.1245/s10434-021-11070-2. PMID: 34839426Free PMC Article
Is the skin microbiota a modifiable risk factor for breast disease?: A systematic review.
Wang K, Nakano K, Naderi N, Bajaj-Elliott M, Mosahebi A
Breast 2021 Oct;59:279-285. Epub 2021 Jul 21 doi: 10.1016/j.breast.2021.07.014. PMID: 34329949Free PMC Article
Systematic review and meta-analysis of the diagnostic accuracy of ductoscopy in patients with pathological nipple discharge.
Waaijer L, Simons JM, Borel Rinkes IH, van Diest PJ, Verkooijen HM, Witkamp AJ
Br J Surg 2016 May;103(6):632-643. Epub 2016 Mar 23 doi: 10.1002/bjs.10125. PMID: 27004588
Bloody nipple discharge as a benign, self-limiting disorder in young children: A systematic review including two related case reports.
Acer T, Derbent M, Hiçsönmez A
J Pediatr Surg 2015 Nov;50(11):1975-82. Epub 2015 Sep 3 doi: 10.1016/j.jpedsurg.2015.08.049. PMID: 26410727

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