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Burkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

MedGen UID:
231973
•Concept ID:
C1332643
•
Neoplastic Process
Synonyms: Burkitt Lymphoma PTLD; Burkitt's Lymphoma Post-Transplant Lymphoproliferative Disorder; Burkitt's Lymphoma PTLD

Definition

A Burkitt lymphoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBurkitt Lymphoma Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Afify Z, Orjuela-Grimm M, Smith CM, Dalal M, Ford JB, Pillai P, Robles JM, Reddy S, McCormack S, Ehrhardt MJ, Ureda T, Alperstein W, Edington H, Miller TP, Rubinstein JD, Kavanaugh M, Bukowinski AJ, Friehling E, Rivers JM, Chisholm KM, Marks LJ, Mason CC
Br J Haematol 2023 Feb;200(3):297-305. Epub 2022 Dec 1 doi: 10.1111/bjh.18498. PMID: 36454546
Diagnosis and treatment of post-transplantation lymphoproliferative disorder in pediatric heart transplant patients.
Schubert S, Abdul-Khaliq H, Lehmkuhl HB, Yegitbasi M, Reinke P, Kebelmann-Betzig C, Hauptmann K, Gross-Wieltsch U, Hetzer R, Berger F
Pediatr Transplant 2009 Feb;13(1):54-62. Epub 2008 Jun 1 doi: 10.1111/j.1399-3046.2008.00969.x. PMID: 18518912
Treatment options for post-transplant lymphoproliferative disorder and other Epstein-Barr virus-associated malignancies.
Davis JE, Moss DJ
Tissue Antigens 2004 Apr;63(4):285-92. doi: 10.1111/j.0001-2815.2004.00227.x. PMID: 15009802

Recent clinical studies

Etiology

Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Afify Z, Orjuela-Grimm M, Smith CM, Dalal M, Ford JB, Pillai P, Robles JM, Reddy S, McCormack S, Ehrhardt MJ, Ureda T, Alperstein W, Edington H, Miller TP, Rubinstein JD, Kavanaugh M, Bukowinski AJ, Friehling E, Rivers JM, Chisholm KM, Marks LJ, Mason CC
Br J Haematol 2023 Feb;200(3):297-305. Epub 2022 Dec 1 doi: 10.1111/bjh.18498. PMID: 36454546
B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.
Capello D, Rossi D, Gaidano G
Hematol Oncol 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. PMID: 16216037

Diagnosis

Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Afify Z, Orjuela-Grimm M, Smith CM, Dalal M, Ford JB, Pillai P, Robles JM, Reddy S, McCormack S, Ehrhardt MJ, Ureda T, Alperstein W, Edington H, Miller TP, Rubinstein JD, Kavanaugh M, Bukowinski AJ, Friehling E, Rivers JM, Chisholm KM, Marks LJ, Mason CC
Br J Haematol 2023 Feb;200(3):297-305. Epub 2022 Dec 1 doi: 10.1111/bjh.18498. PMID: 36454546
B Cell Lymphomas of the GI Tract.
Small S, Barnea Slonim L, Williams C, Karmali R
Curr Gastroenterol Rep 2021 May 8;23(7):9. doi: 10.1007/s11894-021-00811-8. PMID: 33963950
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification.
Grygalewicz B, Woroniecka R, Rymkiewicz G, Rygier J, Malawska N, Blachnio K, Bystydzienski Z, Borysiuk A, Nowakowska B, Pienkowska-Grela B
Cancer Genet 2020 Jul;245:1-5. Epub 2020 May 18 doi: 10.1016/j.cancergen.2020.05.001. PMID: 32531723
B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.
Low LK, Song JY
Surg Pathol Clin 2016 Mar;9(1):55-77. doi: 10.1016/j.path.2015.10.003. PMID: 26940268

Therapy

Burkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Afify Z, Orjuela-Grimm M, Smith CM, Dalal M, Ford JB, Pillai P, Robles JM, Reddy S, McCormack S, Ehrhardt MJ, Ureda T, Alperstein W, Edington H, Miller TP, Rubinstein JD, Kavanaugh M, Bukowinski AJ, Friehling E, Rivers JM, Chisholm KM, Marks LJ, Mason CC
Br J Haematol 2023 Feb;200(3):297-305. Epub 2022 Dec 1 doi: 10.1111/bjh.18498. PMID: 36454546
Post-transplant lymphoproliferative disorder after paediatric liver transplantation.
Liu Y, Sun LY, Zhu ZJ, Wei L, Qu W, Wang L, Yuan LL, Zeng ZG
Int J Clin Pract 2021 Apr;75(4):e13843. Epub 2020 Dec 14 doi: 10.1111/ijcp.13843. PMID: 33222369
Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification.
Grygalewicz B, Woroniecka R, Rymkiewicz G, Rygier J, Malawska N, Blachnio K, Bystydzienski Z, Borysiuk A, Nowakowska B, Pienkowska-Grela B
Cancer Genet 2020 Jul;245:1-5. Epub 2020 May 18 doi: 10.1016/j.cancergen.2020.05.001. PMID: 32531723
The promise of a prophylactic Epstein-Barr virus vaccine.
Balfour HH Jr, Schmeling DO, Grimm-Geris JM
Pediatr Res 2020 Jan;87(2):345-352. Epub 2019 Oct 3 doi: 10.1038/s41390-019-0591-5. PMID: 31641280Free PMC Article
Immunotherapy for Epstein-Barr virus-associated malignancies.
Long HM, Parsonage G, Fox CP, Lee SP
Drug News Perspect 2010 May;23(4):221-8. doi: 10.1358/dnp.2010.23.4.1439500. PMID: 20520851

Prognosis

Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification.
Grygalewicz B, Woroniecka R, Rymkiewicz G, Rygier J, Malawska N, Blachnio K, Bystydzienski Z, Borysiuk A, Nowakowska B, Pienkowska-Grela B
Cancer Genet 2020 Jul;245:1-5. Epub 2020 May 18 doi: 10.1016/j.cancergen.2020.05.001. PMID: 32531723
B-cell Lymphoproliferative Disorders Associated with Primary and Acquired Immunodeficiency.
Low LK, Song JY
Surg Pathol Clin 2016 Mar;9(1):55-77. doi: 10.1016/j.path.2015.10.003. PMID: 26940268
Conservative management of post-transplant central nervous system lymphoma.
Valavoor SH, Ashraf Z, Narwal R, Ratnam S
Int Urol Nephrol 2013 Aug;45(4):1219-22. Epub 2012 Apr 3 doi: 10.1007/s11255-012-0146-8. PMID: 22476860
Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder.
Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, Reyes-Múgica M
Cancer 2011 Oct 1;117(19):4540-50. Epub 2011 Mar 28 doi: 10.1002/cncr.26001. PMID: 21446044
Post-transplant lymphoproliferative disorder after adult-to-adult living donor liver transplant: case series and review of literature.
Kataoka K, Seo S, Sugawara Y, Ota S, Imai Y, Takahashi T, Fukayama M, Kokudo N, Kurokawa M
Leuk Lymphoma 2010 Aug;51(8):1494-501. doi: 10.3109/10428194.2010.492063. PMID: 20578817

Clinical prediction guides

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.
McIntosh MT, Koganti S, Boatwright JL, Li X, Spadaro SV, Brantly AC, Ayers JB, Perez RD, Burton EM, Burgula S, MacCarthy T, Bhaduri-McIntosh S
PLoS Pathog 2020 Oct;16(10):e1008849. Epub 2020 Oct 1 doi: 10.1371/journal.ppat.1008849. PMID: 33002095Free PMC Article
Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.
Öztürk H, Ekşi Bozbulut N, Sarı S, Eğritaş Gürkan Ö, Sözen H, Sapmaz A, Dalgıç A, Dalgıç B
Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233. doi: 10.6002/ect.MESOT2018.P81. PMID: 30777562
Effects of mTOR and calcineurin inhibitors combined therapy in Epstein-Barr virus positive and negative Burkitt lymphoma cells.
Wowro SJ, Schmitt KRL, Tong G, Berger F, Schubert S
Int Immunopharmacol 2016 Jan;30:9-17. Epub 2015 Nov 21 doi: 10.1016/j.intimp.2015.11.020. PMID: 26613512
Adoptive therapy for EBV-induced cancers: driving success with post-transplant lymphoproliferative disorder to other EBV-derived tumors.
Smith C, Khanna R
Immunotherapy 2015;7(5):563-72. doi: 10.2217/imt.15.7. PMID: 26065480
Risk of lymphoma subtypes after solid organ transplantation in the United States.
Clarke CA, Morton LM, Lynch C, Pfeiffer RM, Hall EC, Gibson TM, Weisenburger DD, Martínez-Maza O, Hussain SK, Yang J, Chang ET, Engels EA
Br J Cancer 2013 Jul 9;109(1):280-8. Epub 2013 Jun 11 doi: 10.1038/bjc.2013.294. PMID: 23756857Free PMC Article

Recent systematic reviews

CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360

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