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Grade II Glandular Intraepithelial Neoplasia

MedGen UID:
232253
•Concept ID:
C1333861
•
Neoplastic Process
Synonyms: Grade 2 Glandular Intraepithelial Neoplasia; Moderate Glandular Dysplasia

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade II Glandular Intraepithelial Neoplasia

Professional guidelines

PubMed

Cervicovaginal cytology in the detection of recurrence after cervical cancer treatment.
Rimel BJ, Ferda A, Erwin J, Dewdney SB, Seamon L, Gao F, DeSimone C, Cotney KK, Huh W, Massad LS
Obstet Gynecol 2011 Sep;118(3):548-553. doi: 10.1097/AOG.0b013e3182271fdd. PMID: 21860282
Endocervical glandular cell abnormalities in conventional cervical smears: evaluation of the performance of cytomorphological criteria and HPV testing in predicting neoplasia.
Rabelo-Santos SH, Derchain SF, do Amaral Westin MC, Angelo-Andrade LA, Sarian LO, Oliveira ER, Morais SS, Zeferino LC
Cytopathology 2008 Feb;19(1):34-43. doi: 10.1111/j.1365-2303.2007.00466.x. PMID: 18205627
Incidence and evaluation of an AGUS Papanicolaou smear in primary care.
Valdini A, Vaccaro C, Pechinsky G, Abernathy V
J Am Board Fam Pract 2001 May-Jun;14(3):172-7. PMID: 11355048

Recent clinical studies

Etiology

The effect of local photodynamic therapy with 5-aminolevulinic acid in treating different grades of cervical intraepithelial neoplasia.
Wang B, Su Y, Zhang C, Zhou M, Yuan S, Zhang M, Zhang L, Zhou Y, Cao L, Zhang M, Zhang T
Photodiagnosis Photodyn Ther 2022 Dec;40:103196. Epub 2022 Nov 8 doi: 10.1016/j.pdpdt.2022.103196. PMID: 36368451
Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma.
Nik NN, Vang R, Shih IeM, Kurman RJ
Annu Rev Pathol 2014;9:27-45. Epub 2013 Aug 5 doi: 10.1146/annurev-pathol-020712-163949. PMID: 23937438
Depth of glandular crypts and its involvement in squamous intraepithelial cervical neoplasia submitted to large loop excision of transformation zone (LLETZ).
Okazaki C, Focchi GR, Taha NS, Almeida PQ, Schimidt MA, Speck NM, Ribalta JC
Eur J Gynaecol Oncol 2013;34(1):48-50. PMID: 23590000
Coexisting high-grade glandular and squamous cervical lesions and human papillomavirus infections.
Bekkers RL, Bulten J, Wiersma-van Tilburg A, Mravunac M, Schijf CP, Massuger LF, Quint WG, Melchers WJ
Br J Cancer 2003 Sep 1;89(5):886-90. doi: 10.1038/sj.bjc.6601204. PMID: 12942122Free PMC Article
The Bethesda system and evaluation of abnormal pap smears.
Nguyen HN, Nordqvist SR
Semin Surg Oncol 1999 Apr-May;16(3):217-21. doi: 10.1002/(sici)1098-2388(199904/05)16:3<217::aid-ssu4>3.0.co;2-u. PMID: 10225298

Diagnosis

Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions.
Jakovac H, Stašić N, Krašević M, Jonjić N, Radošević-Stašić B
Virchows Arch 2021 Apr;478(4):735-746. Epub 2020 Oct 21 doi: 10.1007/s00428-020-02947-w. PMID: 33084977Free PMC Article
Depth of glandular crypts and its involvement in squamous intraepithelial cervical neoplasia submitted to large loop excision of transformation zone (LLETZ).
Okazaki C, Focchi GR, Taha NS, Almeida PQ, Schimidt MA, Speck NM, Ribalta JC
Eur J Gynaecol Oncol 2013;34(1):48-50. PMID: 23590000
Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia.
Merrimen JL, Evans AJ, Srigley JR
Pathology 2013 Apr;45(3):251-63. doi: 10.1097/PAT.0b013e32835f6134. PMID: 23478231
Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia.
Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, Shroyer KR
Hum Pathol 2004 Jun;35(6):689-96. doi: 10.1016/j.humpath.2004.02.012. PMID: 15188135
The Bethesda system and evaluation of abnormal pap smears.
Nguyen HN, Nordqvist SR
Semin Surg Oncol 1999 Apr-May;16(3):217-21. doi: 10.1002/(sici)1098-2388(199904/05)16:3<217::aid-ssu4>3.0.co;2-u. PMID: 10225298

Therapy

The effect of local photodynamic therapy with 5-aminolevulinic acid in treating different grades of cervical intraepithelial neoplasia.
Wang B, Su Y, Zhang C, Zhou M, Yuan S, Zhang M, Zhang L, Zhou Y, Cao L, Zhang M, Zhang T
Photodiagnosis Photodyn Ther 2022 Dec;40:103196. Epub 2022 Nov 8 doi: 10.1016/j.pdpdt.2022.103196. PMID: 36368451
Negative predictive value of pap testing: implications for screening intervals for women with human immunodeficiency virus.
Massad LS, DʼSouza G, Tian F, Minkoff H, Cohen M, Wright RL, Colie C, Hessol NA
Obstet Gynecol 2012 Oct;120(4):791-7. doi: 10.1097/AOG.0b013e31826a8bbd. PMID: 22996096Free PMC Article
Endocervical intraepithelial glandular atypia (dysplasia): a histopathologic, human papillomavirus, and MIB-1 analysis of 25 cases.
Lee KR, Sun D, Crum CP
Hum Pathol 2000 Jun;31(6):656-64. doi: 10.1053/hupa.2000.7644. PMID: 10872657
Consequences of neural network technology for cervical screening: increase in diagnostic consistency and positive scores.
Kok MR, Boon ME
Cancer 1996 Jul 1;78(1):112-7. doi: 10.1002/(SICI)1097-0142(19960701)78:1<112::AID-CNCR16>3.0.CO;2-2. PMID: 8646706

Prognosis

Cytology of cervical intraepithelial glandular lesions.
Ovanin-Rakić A, Mahovlić V, Audy-Jurković S, Barisić A, Skopljanac-Macina L, Jurić D, Rajhvajn S, Ilić-Forko J, Babić D, Folnović D, Kani D
Coll Antropol 2010 Jun;34(2):401-6. PMID: 20698109
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
Prediction of high-grade cervical disease with human papillomavirus detection in women with glandular and squamous cytologic abnormalities.
de Oliveira ER, Derchain SF, Sarian LO, Rabelo-Santos SH, Gontijo RC, Yoshida A, Andrade LA, Zeferino LC
Int J Gynecol Cancer 2006 May-Jun;16(3):1055-62. doi: 10.1111/j.1525-1438.2006.00462.x. PMID: 16803485
Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate.
Zeng L, Rowland RG, Lele SM, Kyprianou N
Hum Pathol 2004 Mar;35(3):290-7. doi: 10.1016/j.humpath.2003.11.001. PMID: 15017584
The Bethesda system and evaluation of abnormal pap smears.
Nguyen HN, Nordqvist SR
Semin Surg Oncol 1999 Apr-May;16(3):217-21. doi: 10.1002/(sici)1098-2388(199904/05)16:3<217::aid-ssu4>3.0.co;2-u. PMID: 10225298

Clinical prediction guides

The effect of local photodynamic therapy with 5-aminolevulinic acid in treating different grades of cervical intraepithelial neoplasia.
Wang B, Su Y, Zhang C, Zhou M, Yuan S, Zhang M, Zhang L, Zhou Y, Cao L, Zhang M, Zhang T
Photodiagnosis Photodyn Ther 2022 Dec;40:103196. Epub 2022 Nov 8 doi: 10.1016/j.pdpdt.2022.103196. PMID: 36368451
Depth of glandular crypts and its involvement in squamous intraepithelial cervical neoplasia submitted to large loop excision of transformation zone (LLETZ).
Okazaki C, Focchi GR, Taha NS, Almeida PQ, Schimidt MA, Speck NM, Ribalta JC
Eur J Gynaecol Oncol 2013;34(1):48-50. PMID: 23590000
Topographic and quantitative relationship between prostate inflammation, proliferative inflammatory atrophy and low-grade prostate intraepithelial neoplasia: a biopsy study in chronic prostatitis patients.
Vral A, Magri V, Montanari E, Gazzano G, Gourvas V, Marras E, Perletti G
Int J Oncol 2012 Dec;41(6):1950-8. Epub 2012 Oct 1 doi: 10.3892/ijo.2012.1646. PMID: 23026863Free PMC Article
Prediction of high-grade cervical disease with human papillomavirus detection in women with glandular and squamous cytologic abnormalities.
de Oliveira ER, Derchain SF, Sarian LO, Rabelo-Santos SH, Gontijo RC, Yoshida A, Andrade LA, Zeferino LC
Int J Gynecol Cancer 2006 May-Jun;16(3):1055-62. doi: 10.1111/j.1525-1438.2006.00462.x. PMID: 16803485
The Bethesda system and evaluation of abnormal pap smears.
Nguyen HN, Nordqvist SR
Semin Surg Oncol 1999 Apr-May;16(3):217-21. doi: 10.1002/(sici)1098-2388(199904/05)16:3<217::aid-ssu4>3.0.co;2-u. PMID: 10225298

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