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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia

MedGen UID:
232427
Concept ID:
C1333291
Disease or Syndrome
Synonyms: Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia; diffuse idiopathic pulmonary neuroendocrine cell hyperplasia; DIP-NECH; DIPNECH
 
Monarch Initiative: MONDO:0022986
Orphanet: ORPHA617916

Definition

A very rare condition characterized by generalized proliferation of pulmonary neuroendocrine cells. It manifests as progressive cough and dyspnea. It is considered a precursor for pulmonary carcinoid tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse idiopathic pulmonary neuroendocrine cell hyperplasia

Professional guidelines

PubMed

Al-Toubah T, Grozinsky-Glasberg S, Strosberg J
Curr Treat Options Oncol 2021 Feb 27;22(4):28. doi: 10.1007/s11864-021-00828-1. PMID: 33641079
Myint ZW, McCormick J, Chauhan A, Behrens E, Anthony LB
Lung 2018 Oct;196(5):577-581. Epub 2018 Aug 25 doi: 10.1007/s00408-018-0149-z. PMID: 30167840
Lamarca A, Pritchard DM, Westwood T, Papaxoinis G, Nonaka D, Vinjamuri S, Valle JW, Manoharan P, Mansoor W
Neuroendocrinology 2018;106(2):128-138. Epub 2017 Apr 12 doi: 10.1159/000472717. PMID: 28399530

Recent clinical studies

Etiology

Hayes AR, Luong TV, Banks J, Shah H, Watkins J, Lim E, Patel A, Grossman AB, Navalkissoor S, Krell D, Caplin ME
J Neuroendocrinol 2022 Oct;34(10):e13184. Epub 2022 Sep 19 doi: 10.1111/jne.13184. PMID: 36121922
Chauhan A, Ramirez RA
Lung 2015 Oct;193(5):653-7. Epub 2015 Jun 26 doi: 10.1007/s00408-015-9754-2. PMID: 26112453
Wirtschafter E, Walts AE, Liu ST, Marchevsky AM
Lung 2015 Oct;193(5):659-67. Epub 2015 Jun 24 doi: 10.1007/s00408-015-9755-1. PMID: 26104490
Koo CW, Baliff JP, Torigian DA, Litzky LA, Gefter WB, Akers SR
AJR Am J Roentgenol 2010 Sep;195(3):661-8. doi: 10.2214/AJR.09.3811. PMID: 20729444
Lantuéjoul S, Salameire D, Salon C, Brambilla E
Histopathology 2009 Jan;54(1):43-54. doi: 10.1111/j.1365-2559.2008.03182.x. PMID: 19187179

Diagnosis

Herrán de la Gala D, Calapaquí Terán AK, Peña Gómez ME
Pulmonology 2022 Jul-Aug;28(4):324-325. Epub 2022 Feb 2 doi: 10.1016/j.pulmoe.2021.12.011. PMID: 35123926
Myint ZW, McCormick J, Chauhan A, Behrens E, Anthony LB
Lung 2018 Oct;196(5):577-581. Epub 2018 Aug 25 doi: 10.1007/s00408-018-0149-z. PMID: 30167840
Koliakos E, Thomopoulos T, Abbassi Z, Duc C, Christodoulou M
Am J Case Rep 2017 Sep 11;18:975-979. doi: 10.12659/ajcr.904468. PMID: 28890532Free PMC Article
Rossi G, Cavazza A, Spagnolo P, Sverzellati N, Longo L, Jukna A, Montanari G, Carbonelli C, Vincenzi G, Bogina G, Franco R, Tiseo M, Cottin V, Colby TV
Eur Respir J 2016 Jun;47(6):1829-41. Epub 2016 Apr 13 doi: 10.1183/13993003.01954-2015. PMID: 27076588
Marchevsky AM, Walts AE
Semin Diagn Pathol 2015 Nov;32(6):438-44. Epub 2015 Sep 1 doi: 10.1053/j.semdp.2015.08.002. PMID: 26472691

Therapy

Al-Toubah T, Strosberg J, Halfdanarson TR, Oleinikov K, Gross DJ, Haider M, Sonbol MB, Almquist D, Grozinsky-Glasberg S
Chest 2020 Jul;158(1):401-405. Epub 2020 Feb 12 doi: 10.1016/j.chest.2020.01.031. PMID: 32059961
Myint ZW, McCormick J, Chauhan A, Behrens E, Anthony LB
Lung 2018 Oct;196(5):577-581. Epub 2018 Aug 25 doi: 10.1007/s00408-018-0149-z. PMID: 30167840
Chauhan A, Ramirez RA
Lung 2015 Oct;193(5):653-7. Epub 2015 Jun 26 doi: 10.1007/s00408-015-9754-2. PMID: 26112453
Wirtschafter E, Walts AE, Liu ST, Marchevsky AM
Lung 2015 Oct;193(5):659-67. Epub 2015 Jun 24 doi: 10.1007/s00408-015-9755-1. PMID: 26104490
Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118

Prognosis

Hayes AR, Luong TV, Banks J, Shah H, Watkins J, Lim E, Patel A, Grossman AB, Navalkissoor S, Krell D, Caplin ME
J Neuroendocrinol 2022 Oct;34(10):e13184. Epub 2022 Sep 19 doi: 10.1111/jne.13184. PMID: 36121922
Almquist DR, Ernani V, Sonbol MB
Curr Opin Pulm Med 2021 Jul 1;27(4):255-261. doi: 10.1097/MCP.0000000000000776. PMID: 33927131
Little BP, Junn JC, Zheng KS, Sanchez FW, Henry TS, Veeraraghavan S, Berkowitz EA
AJR Am J Roentgenol 2020 Dec;215(6):1312-1320. Epub 2020 Oct 6 doi: 10.2214/AJR.19.22628. PMID: 33021835
Koliakos E, Thomopoulos T, Abbassi Z, Duc C, Christodoulou M
Am J Case Rep 2017 Sep 11;18:975-979. doi: 10.12659/ajcr.904468. PMID: 28890532Free PMC Article
Marchevsky AM, Walts AE
Semin Diagn Pathol 2015 Nov;32(6):438-44. Epub 2015 Sep 1 doi: 10.1053/j.semdp.2015.08.002. PMID: 26472691

Clinical prediction guides

Prieto M, Chassagnon G, Lupo A, Charpentier MC, Cabanne E, Groussin L, Wislez M, Alifano M, Fournel L
Lung Cancer 2021 Jun;156:117-121. Epub 2021 Apr 30 doi: 10.1016/j.lungcan.2021.04.024. PMID: 33940544
Little BP, Junn JC, Zheng KS, Sanchez FW, Henry TS, Veeraraghavan S, Berkowitz EA
AJR Am J Roentgenol 2020 Dec;215(6):1312-1320. Epub 2020 Oct 6 doi: 10.2214/AJR.19.22628. PMID: 33021835
Jin L, Wang Z, Qi X
Medicine (Baltimore) 2018 Dec;97(52):e13806. doi: 10.1097/MD.0000000000013806. PMID: 30593169Free PMC Article
Rossi G, Bertero L, Marchiò C, Papotti M
Histopathology 2018 Jan;72(1):142-152. doi: 10.1111/his.13394. PMID: 29239031
Gorshtein A, Gross DJ, Barak D, Strenov Y, Refaeli Y, Shimon I, Grozinsky-Glasberg S
Cancer 2012 Feb 1;118(3):612-9. Epub 2011 Jul 12 doi: 10.1002/cncr.26200. PMID: 21751183

Recent systematic reviews

Wirtschafter E, Walts AE, Liu ST, Marchevsky AM
Lung 2015 Oct;193(5):659-67. Epub 2015 Jun 24 doi: 10.1007/s00408-015-9755-1. PMID: 26104490
Nassar AA, Jaroszewski DE, Helmers RA, Colby TV, Patel BM, Mookadam F
Am J Respir Crit Care Med 2011 Jul 1;184(1):8-16. Epub 2011 Mar 25 doi: 10.1164/rccm.201010-1685PP. PMID: 21471097

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