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Gastric mucosa-associated lymphoid tissue lymphoma

MedGen UID:
232547
•Concept ID:
C1333782
•
Neoplastic Process
Synonyms: Gastric MALT Lymphoma; gastric MALT lymphoma; Gastric MALToma; gastric MALToma; Gastric Mucosa-Associated Lymphoid Tissue Lymphoma; gastric mucosa-associated lymphoid tissue lymphoma; MALT Lymphoma of Stomach; MALT lymphoma of stomach; MALT Lymphoma of the Stomach; MALT lymphoma of the stomach; MALToma of Stomach; MALToma of stomach; MALToma of the Stomach; MALToma of the stomach; Primary Gastric B-Cell MALT Lymphoma; primary gastric B-cell MALT lymphoma; Primary Gastric MALT Lymphoma; primary gastric MALT lymphoma; Primary MALT Lymphoma of Stomach; primary MALT lymphoma of stomach; Primary MALT Lymphoma of the Stomach; primary MALT lymphoma of the stomach; stomach MALT lymphoma
 
Monarch Initiative: MONDO:0006226

Definition

A low grade, indolent B-cell lymphoma, usually associated with Helicobacter pylori infection. Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation. Approximately 40% of gastric MALT lymphomas carry the t(11;18)(q21;q21). Such cases are resistant to Helicobacter pylori therapy. [from NCI]

Professional guidelines

PubMed

Treatment Strategy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.
Nakamura S, Matsumoto T
Gastroenterol Clin North Am 2015 Sep;44(3):649-60. Epub 2015 Jun 23 doi: 10.1016/j.gtc.2015.05.012. PMID: 26314674
Management of gastric mucosa-associated lymphoid tissue lymphoma.
Neumeister P, Troppan K, Raderer M
Dig Dis 2015;33(1):11-8. Epub 2014 Dec 17 doi: 10.1159/000366030. PMID: 25531492
Treatment of Helicobacter pylori infection: current status and future concepts.
Yang JC, Lu CW, Lin CJ
World J Gastroenterol 2014 May 14;20(18):5283-93. doi: 10.3748/wjg.v20.i18.5283. PMID: 24833858Free PMC Article

Recent clinical studies

Etiology

Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma in real-world experience.
Min GJ, Kang D, Lee HH, Kim SJ, Kim TY, Jeon YW, O JH, Choi BO, Park G, Cho SG
Ann Hematol 2023 Apr;102(4):877-888. Epub 2023 Feb 25 doi: 10.1007/s00277-023-05130-8. PMID: 36840791Free PMC Article
Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis.
Keikha M, Sahebkar A, Yamaoka Y, Karbalaei M
J Health Popul Nutr 2022 Jan 3;41(1):2. doi: 10.1186/s41043-021-00280-9. PMID: 34980267Free PMC Article
Clinical features & treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma.
Yang H, Jielili A, Cao Z, Yuan T
Indian J Med Res 2021 Mar;154(3):504-508. doi: 10.4103/ijmr.IJMR_2102_18. PMID: 35345077Free PMC Article
H. pylori infection and extra-gastroduodenal diseases.
Tsay FW, Hsu PI
J Biomed Sci 2018 Aug 29;25(1):65. doi: 10.1186/s12929-018-0469-6. PMID: 30157866Free PMC Article
Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma: recent progress in pathogenesis and management.
Nakamura S, Matsumoto T
World J Gastroenterol 2013 Dec 7;19(45):8181-7. doi: 10.3748/wjg.v19.i45.8181. PMID: 24363507Free PMC Article

Diagnosis

Helicobacter pylori infection.
Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S
Nat Rev Dis Primers 2023 Apr 20;9(1):19. doi: 10.1038/s41572-023-00431-8. PMID: 37081005
The role of miRNAs and epigenetic mechanisms in primary gastric mucosa-associated lymphoid tissue lymphoma.
Vasilatou D, Sioulas AD, Pappa V, Papanikolaou IS, Triantafyllou K, Dimitriadis GD, Papageorgiou SG
Future Oncol 2016 Jul;12(13):1587-93. Epub 2016 Apr 15 doi: 10.2217/fon-2016-0038. PMID: 27079806
Management of gastric mucosa-associated lymphoid tissue lymphoma.
Neumeister P, Troppan K, Raderer M
Dig Dis 2015;33(1):11-8. Epub 2014 Dec 17 doi: 10.1159/000366030. PMID: 25531492
Treatment of Helicobacter pylori infection: current status and future concepts.
Yang JC, Lu CW, Lin CJ
World J Gastroenterol 2014 May 14;20(18):5283-93. doi: 10.3748/wjg.v20.i18.5283. PMID: 24833858Free PMC Article
Endoscopic diagnosis and staging of mucosa-associated lymphoid tissue lymphoma.
Mehra M, Agarwal B
Curr Opin Gastroenterol 2008 Sep;24(5):623-6. doi: 10.1097/MOG.0b013e32830bf80f. PMID: 19122505

Therapy

Helicobacter pylori infection.
Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, Smith SI, Suerbaum S
Nat Rev Dis Primers 2023 Apr 20;9(1):19. doi: 10.1038/s41572-023-00431-8. PMID: 37081005
Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance.
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Treatment of Helicobacter pylori infection: current status and future concepts.
Yang JC, Lu CW, Lin CJ
World J Gastroenterol 2014 May 14;20(18):5283-93. doi: 10.3748/wjg.v20.i18.5283. PMID: 24833858Free PMC Article
Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma: recent progress in pathogenesis and management.
Nakamura S, Matsumoto T
World J Gastroenterol 2013 Dec 7;19(45):8181-7. doi: 10.3748/wjg.v19.i45.8181. PMID: 24363507Free PMC Article
Therapy of gastric mucosa associated lymphoid tissue lymphoma.
Morgner A, Schmelz R, Thiede C, Stolte M, Miehlke S
World J Gastroenterol 2007 Jul 14;13(26):3554-66. doi: 10.3748/wjg.v13.i26.3554. PMID: 17659705Free PMC Article

Prognosis

Long-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma in real-world experience.
Min GJ, Kang D, Lee HH, Kim SJ, Kim TY, Jeon YW, O JH, Choi BO, Park G, Cho SG
Ann Hematol 2023 Apr;102(4):877-888. Epub 2023 Feb 25 doi: 10.1007/s00277-023-05130-8. PMID: 36840791Free PMC Article
Perforation caused by gastric mucosa associated lymphoid tissue lymphoma: A case report and literature review.
Ma X, Qin L, Liu Y, Bian W, Sun D
Medicine (Baltimore) 2018 Aug;97(33):e11713. doi: 10.1097/MD.0000000000011713. PMID: 30113456Free PMC Article
The role of miRNAs and epigenetic mechanisms in primary gastric mucosa-associated lymphoid tissue lymphoma.
Vasilatou D, Sioulas AD, Pappa V, Papanikolaou IS, Triantafyllou K, Dimitriadis GD, Papageorgiou SG
Future Oncol 2016 Jul;12(13):1587-93. Epub 2016 Apr 15 doi: 10.2217/fon-2016-0038. PMID: 27079806
Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma.
Park JB, Koo JS
World J Gastroenterol 2014 Mar 21;20(11):2751-9. doi: 10.3748/wjg.v20.i11.2751. PMID: 24659867Free PMC Article
Treatment of gastric mucosa-associated lymphoid tissue lymphoma: Helicobacter pylori eradication and beyond.
Montalban C, Norman F
Expert Rev Anticancer Ther 2006 Mar;6(3):361-71. doi: 10.1586/14737140.6.3.361. PMID: 16503853

Clinical prediction guides

Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis.
Keikha M, Sahebkar A, Yamaoka Y, Karbalaei M
J Health Popul Nutr 2022 Jan 3;41(1):2. doi: 10.1186/s41043-021-00280-9. PMID: 34980267Free PMC Article
Perforation caused by gastric mucosa associated lymphoid tissue lymphoma: A case report and literature review.
Ma X, Qin L, Liu Y, Bian W, Sun D
Medicine (Baltimore) 2018 Aug;97(33):e11713. doi: 10.1097/MD.0000000000011713. PMID: 30113456Free PMC Article
Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance.
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma.
Park JB, Koo JS
World J Gastroenterol 2014 Mar 21;20(11):2751-9. doi: 10.3748/wjg.v20.i11.2751. PMID: 24659867Free PMC Article
Endoscopic diagnosis and staging of mucosa-associated lymphoid tissue lymphoma.
Mehra M, Agarwal B
Curr Opin Gastroenterol 2008 Sep;24(5):623-6. doi: 10.1097/MOG.0b013e32830bf80f. PMID: 19122505

Recent systematic reviews

Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis.
Keikha M, Sahebkar A, Yamaoka Y, Karbalaei M
J Health Popul Nutr 2022 Jan 3;41(1):2. doi: 10.1186/s41043-021-00280-9. PMID: 34980267Free PMC Article
Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma.
Zullo A, Hassan C, Cristofari F, Andriani A, De Francesco V, Ierardi E, Tomao S, Stolte M, Morini S, Vaira D
Clin Gastroenterol Hepatol 2010 Feb;8(2):105-10. Epub 2009 Jul 22 doi: 10.1016/j.cgh.2009.07.017. PMID: 19631287

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