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Grade II Penile Intraepithelial Neoplasia

MedGen UID:
232565
•Concept ID:
C1333863
•
Neoplastic Process
Synonyms: Grade 2 Penile Intraepithelial Neoplasia; Grade II PeIN

Definition

Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower two thirds of the epithelial thickness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade II Penile Intraepithelial Neoplasia

Recent clinical studies

Etiology

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Morphological features of epithelial abnormalities and precancerous lesions of the penis.
Cubilla AL, Meijer CJ, Young RH
Scand J Urol Nephrol Suppl 2000;(205):215-9. PMID: 11144900
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625
Difficulty in elucidating the male role in cervical cancer in Colombia, a high-risk area for the disease.
Muñoz N, Castellsagué X, Bosch FX, Tafur L, de Sanjosé S, Aristizabal N, Ghaffari AM, Shah KV
J Natl Cancer Inst 1996 Aug 7;88(15):1068-75. doi: 10.1093/jnci/88.15.1068. PMID: 8683638
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280

Diagnosis

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Hoekstra RJ, Trip EJ, Ten Kate FJ, Horenblas S, Lock MT
Int J Urol 2019 Mar;26(3):353-357. Epub 2018 Dec 3 doi: 10.1111/iju.13871. PMID: 30508877
The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions.
Giraldo PC, Eleutério J Jr, Cavalcante DI, Gonçalves AK, Romão JA, Eleutério RM
Eur J Obstet Gynecol Reprod Biol 2008 Mar;137(1):88-91. Epub 2007 May 7 doi: 10.1016/j.ejogrb.2006.12.026. PMID: 17485158
Squamous cell carcinoma of the penis: multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy.
Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C, Perrin JL, Court B, Wibault P, Théodore C
Ann Oncol 1997 Nov;8(11):1089-98. doi: 10.1023/a:1008248319036. PMID: 9426328
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625

Therapy

Treatment of penile intraepithelial neoplasia (PIN) with interferon alpha-2a, CO2 laser (vaporization) and 5-fluorouracil 5% (5-FU).
Cardamakis E, Relakis K, Ginopoulos P, Korantzis A, Metalinos K, Stathopoulos E, Papathanasiou Z, Michopoulos J, Mantouvalos H, Kotoulas IG, Tzingounis V
Eur J Gynaecol Oncol 1997;18(5):410-3. PMID: 9378164

Prognosis

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Hoekstra RJ, Trip EJ, Ten Kate FJ, Horenblas S, Lock MT
Int J Urol 2019 Mar;26(3):353-357. Epub 2018 Dec 3 doi: 10.1111/iju.13871. PMID: 30508877
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625
Difficulty in elucidating the male role in cervical cancer in Colombia, a high-risk area for the disease.
Muñoz N, Castellsagué X, Bosch FX, Tafur L, de Sanjosé S, Aristizabal N, Ghaffari AM, Shah KV
J Natl Cancer Inst 1996 Aug 7;88(15):1068-75. doi: 10.1093/jnci/88.15.1068. PMID: 8683638
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280

Clinical prediction guides

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
The role of high-risk HPV-DNA testing in the male sexual partners of women with HPV-induced lesions.
Giraldo PC, Eleutério J Jr, Cavalcante DI, Gonçalves AK, Romão JA, Eleutério RM
Eur J Obstet Gynecol Reprod Biol 2008 Mar;137(1):88-91. Epub 2007 May 7 doi: 10.1016/j.ejogrb.2006.12.026. PMID: 17485158
Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.
Schmidt-Grimminger DC, Wu X, Jian Y, Broker TR, Chow LT
Am J Pathol 1998 Apr;152(4):1015-24. PMID: 9546362Free PMC Article
Squamous cell carcinoma of the penis: multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy.
Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C, Perrin JL, Court B, Wibault P, Théodore C
Ann Oncol 1997 Nov;8(11):1089-98. doi: 10.1023/a:1008248319036. PMID: 9426328
Carcinoma of the penis: analysis of 192 consecutive cases at the Instituto Nacional de Enfermedades Neoplasicas.
Pow-Sang J, Ojeda J, Ramirez G, Olivares L, Benavente V, Sanchez L
Int Adv Surg Oncol 1979;2:201-21. PMID: 399945

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