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Cardiac Myeloid Sarcoma

MedGen UID:
232590
•Concept ID:
C1333946
•
Neoplastic Process
Synonyms: Cardiac Extramedullary Myeloid Neoplasm; Cardiac Extramedullary Myeloid Tumor; Extramedullary Myeloid Neoplasm of Heart; Extramedullary Myeloid Neoplasm of the Heart; Extramedullary Myeloid Tumor of Heart; Extramedullary Myeloid Tumor of the Heart; Heart Extramedullary Myeloid Neoplasm; Heart Extramedullary Myeloid Tumor; Heart Myeloid Sarcoma

Definition

A rare extramedullary myeloid tumor that arises from the heart. It may present in association with or as a site of relapse of acute myeloid leukemia. Rare cases of myeloid sarcoma of the heart preceding acute myeloid leukemia have also been reported. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiac Myeloid Sarcoma

Professional guidelines

PubMed

Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.
van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2014 Sep 4;(9):CD006647. doi: 10.1002/14651858.CD006647.pub4. PMID: 25188452

Recent clinical studies

Etiology

Multimodality imaging and histopathology of cardiac myeloid sarcoma.
Wang Y, Wu W, Zhong D, Han X, Fang L
Eur Heart J Cardiovasc Imaging 2016 Nov;17(11):1316. Epub 2016 Jul 25 doi: 10.1093/ehjci/jew143. PMID: 27458183
Cardiac myeloid sarcoma: a case report and review of literature.
Cash T, Becton D, Mian A
J Pediatr Hematol Oncol 2011 Oct;33(7):e330-2. doi: 10.1097/MPH.0b013e3182329b6b. PMID: 21941137

Diagnosis

Myeloid sarcoma of the heart: Extramedullary relapse of acute myeloblastic leukemia, presenting with complete heart block and atrial flutter after second allogeneic stem cell transplantation.
Babaoğlu K, Azizoğlu M, Başar EZ, Zengin E, Usta E, Sarper N
Echocardiography 2021 Jun;38(6):1084-1088. Epub 2021 May 21 doi: 10.1111/echo.15095. PMID: 34018636
Cardiac chloroma or cardiac myeloid sarcoma: Case Report.
Abdelnabi MH, Almaghraby A, Saleh Y, ElSharkawy E
Echocardiography 2019 Aug;36(8):1594-1595. Epub 2019 Aug 12 doi: 10.1111/echo.14443. PMID: 31403739
Heart failure due to cardiac myeloid sarcoma.
Tiller C, Reindl M, Klug G, Metzler B, Reinstadler SJ
Eur Heart J Cardiovasc Imaging 2019 May 1;20(5):501. doi: 10.1093/ehjci/jey226. PMID: 30649243
Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma.
Waselewski A, Joiner M, Miller SR
BMJ Case Rep 2018 Nov 1;2018 doi: 10.1136/bcr-2018-224419. PMID: 30389743Free PMC Article
Cardiac myeloid sarcoma: a case report and review of literature.
Cash T, Becton D, Mian A
J Pediatr Hematol Oncol 2011 Oct;33(7):e330-2. doi: 10.1097/MPH.0b013e3182329b6b. PMID: 21941137

Therapy

Myeloid sarcoma of the heart: Extramedullary relapse of acute myeloblastic leukemia, presenting with complete heart block and atrial flutter after second allogeneic stem cell transplantation.
Babaoğlu K, Azizoğlu M, Başar EZ, Zengin E, Usta E, Sarper N
Echocardiography 2021 Jun;38(6):1084-1088. Epub 2021 May 21 doi: 10.1111/echo.15095. PMID: 34018636
Cardiac myeloid sarcoma: a case report and review of literature.
Cash T, Becton D, Mian A
J Pediatr Hematol Oncol 2011 Oct;33(7):e330-2. doi: 10.1097/MPH.0b013e3182329b6b. PMID: 21941137

Prognosis

Cardiac chloroma or cardiac myeloid sarcoma: Case Report.
Abdelnabi MH, Almaghraby A, Saleh Y, ElSharkawy E
Echocardiography 2019 Aug;36(8):1594-1595. Epub 2019 Aug 12 doi: 10.1111/echo.14443. PMID: 31403739
Heart failure due to cardiac myeloid sarcoma.
Tiller C, Reindl M, Klug G, Metzler B, Reinstadler SJ
Eur Heart J Cardiovasc Imaging 2019 May 1;20(5):501. doi: 10.1093/ehjci/jey226. PMID: 30649243
Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma.
Waselewski A, Joiner M, Miller SR
BMJ Case Rep 2018 Nov 1;2018 doi: 10.1136/bcr-2018-224419. PMID: 30389743Free PMC Article
Multimodality imaging and histopathology of cardiac myeloid sarcoma.
Wang Y, Wu W, Zhong D, Han X, Fang L
Eur Heart J Cardiovasc Imaging 2016 Nov;17(11):1316. Epub 2016 Jul 25 doi: 10.1093/ehjci/jew143. PMID: 27458183
Cardiac myeloid sarcoma: a case report and review of literature.
Cash T, Becton D, Mian A
J Pediatr Hematol Oncol 2011 Oct;33(7):e330-2. doi: 10.1097/MPH.0b013e3182329b6b. PMID: 21941137

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