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Low Grade Conjunctival Squamous Intraepithelial Neoplasia

MedGen UID:
232704
•Concept ID:
C1334421
•
Neoplastic Process
Synonyms: Grade 1 Conjunctival Intraepithelial Neoplasia; Grade I Conjunctival Intraepithelial Neoplasia; Low Grade Conjunctival Intraepithelial Neoplasia

Definition

A precancerous neoplastic intraepithelial process with low-grade dysplastic features involving the conjunctival epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Conjunctival Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma.
Moyer AB, Roberts J, Olsen RJ, Chévez-Barrios P
Am J Dermatopathol 2018 Jul;40(7):486-490. doi: 10.1097/DAD.0000000000001139. PMID: 29533279
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Zoroquiain P, Faingold D, Algahmdi S, Vila N, Logan P, Sanft DM, Toledo Dias AB, Aldrees S, Bravo-Filho V, Burnier J, Burnier MN
Am J Clin Pathol 2016 Mar;145(3):385-92. doi: 10.1093/ajcp/aqw007. PMID: 27124921

Recent clinical studies

Etiology

Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region.
Hossain RR, McKelvie J
Eye (Lond) 2022 Aug;36(8):1567-1570. Epub 2021 Jul 14 doi: 10.1038/s41433-021-01662-3. PMID: 34262162Free PMC Article
Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review.
Fasina O
Int Ophthalmol 2021 Oct;41(10):3325-3331. Epub 2021 May 20 doi: 10.1007/s10792-021-01894-y. PMID: 34014459
Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma.
Moyer AB, Roberts J, Olsen RJ, Chévez-Barrios P
Am J Dermatopathol 2018 Jul;40(7):486-490. doi: 10.1097/DAD.0000000000001139. PMID: 29533279
Human papillomaviruses in intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva: a study from Mozambique.
Carrilho C, Gouveia P, Yokohama H, Lopes JM, Lunet N, Ferro J, Ismail M, Walboomers J, Sobrinho-Simões M, David L
Eur J Cancer Prev 2013 Nov;22(6):566-8. doi: 10.1097/CEJ.0b013e328363005d. PMID: 23752127Free PMC Article
Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma.
Heindl LM, Hofmann-Rummelt C, Adler W, Holbach LM, Naumann GO, Kruse FE, Cursiefen C
Ophthalmology 2010 Apr;117(4):649-58. doi: 10.1016/j.ophtha.2010.01.032. PMID: 20346821

Diagnosis

Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region.
Hossain RR, McKelvie J
Eye (Lond) 2022 Aug;36(8):1567-1570. Epub 2021 Jul 14 doi: 10.1038/s41433-021-01662-3. PMID: 34262162Free PMC Article
Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review.
Fasina O
Int Ophthalmol 2021 Oct;41(10):3325-3331. Epub 2021 May 20 doi: 10.1007/s10792-021-01894-y. PMID: 34014459
Human papillomavirus (HPV)-associated trilateral squamous neoplasia in immunocompetent individual.
Iovieno A, Piana S, Chiesi L, Fodero C, Fontana L
Int Ophthalmol 2018 Jun;38(3):1347-1350. Epub 2017 Jun 6 doi: 10.1007/s10792-017-0573-8. PMID: 28589289
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Zoroquiain P, Faingold D, Algahmdi S, Vila N, Logan P, Sanft DM, Toledo Dias AB, Aldrees S, Bravo-Filho V, Burnier J, Burnier MN
Am J Clin Pathol 2016 Mar;145(3):385-92. doi: 10.1093/ajcp/aqw007. PMID: 27124921
Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion.
Kuo KT, Chang HC, Hsiao CH, Lin MC
Br J Ophthalmol 2006 Jul;90(7):894-9. Epub 2006 Mar 15 doi: 10.1136/bjo.2005.086314. PMID: 16540490Free PMC Article

Therapy

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486

Prognosis

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486
Ocular surface squamous neoplasia in New Zealand: a ten-year review of incidence in the Waikato region.
Hossain RR, McKelvie J
Eye (Lond) 2022 Aug;36(8):1567-1570. Epub 2021 Jul 14 doi: 10.1038/s41433-021-01662-3. PMID: 34262162Free PMC Article
Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review.
Fasina O
Int Ophthalmol 2021 Oct;41(10):3325-3331. Epub 2021 May 20 doi: 10.1007/s10792-021-01894-y. PMID: 34014459
Human papillomaviruses in intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva: a study from Mozambique.
Carrilho C, Gouveia P, Yokohama H, Lopes JM, Lunet N, Ferro J, Ismail M, Walboomers J, Sobrinho-Simões M, David L
Eur J Cancer Prev 2013 Nov;22(6):566-8. doi: 10.1097/CEJ.0b013e328363005d. PMID: 23752127Free PMC Article
Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma.
Heindl LM, Hofmann-Rummelt C, Adler W, Holbach LM, Naumann GO, Kruse FE, Cursiefen C
Ophthalmology 2010 Apr;117(4):649-58. doi: 10.1016/j.ophtha.2010.01.032. PMID: 20346821

Clinical prediction guides

Efficacy and safety of topical 5-fluorouracil in conjunctival intraepithelial neoplasia refractory to interferon alpha-2b.
Pérez-García P, Burgos-Blasco B, Gómez-Calleja V, Vidal-Villegas B, Méndez-Fernández R, Gegúndez-Fernández JA, Díaz-Valle D
J Oncol Pharm Pract 2023 Jun;29(4):975-979. Epub 2022 Sep 21 doi: 10.1177/10781552221125763. PMID: 36131486
Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma.
Moyer AB, Roberts J, Olsen RJ, Chévez-Barrios P
Am J Dermatopathol 2018 Jul;40(7):486-490. doi: 10.1097/DAD.0000000000001139. PMID: 29533279
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Zoroquiain P, Faingold D, Algahmdi S, Vila N, Logan P, Sanft DM, Toledo Dias AB, Aldrees S, Bravo-Filho V, Burnier J, Burnier MN
Am J Clin Pathol 2016 Mar;145(3):385-92. doi: 10.1093/ajcp/aqw007. PMID: 27124921
Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma.
Heindl LM, Hofmann-Rummelt C, Adler W, Holbach LM, Naumann GO, Kruse FE, Cursiefen C
Ophthalmology 2010 Apr;117(4):649-58. doi: 10.1016/j.ophtha.2010.01.032. PMID: 20346821

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