U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rectum leiomyosarcoma

MedGen UID:
233391
•Concept ID:
C1335683
•
Neoplastic Process
Synonyms: Leiomyosarcoma of rectum; Leiomyosarcoma of Rectum; leiomyosarcoma of rectum; Leiomyosarcoma of the Rectum; leiomyosarcoma of the rectum; Rectal Leiomyosarcoma; rectal leiomyosarcoma; rectum leiomyosarcoma
SNOMED CT: Leiomyosarcoma of rectum (1156783003)
 
Monarch Initiative: MONDO:0003379

Definition

An aggressive malignant smooth muscle neoplasm that arises from the rectum. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectum leiomyosarcoma

Professional guidelines

PubMed

Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830
Benign and malignant neoplasms of colon and rectum. Diagnosis and management.
Stearns MW Jr
Surg Clin North Am 1978 Jun;58(3):605-18. doi: 10.1016/s0039-6109(16)41542-2. PMID: 354056

Recent clinical studies

Etiology

Computed tomography and magnetic resonance imaging findings in dogs with vaginal leiomyoma and leiomyosarcoma.
Tanaka T, Noguchi S, Wada Y, Yamazaki H, Nishida H, Akiyoshi H
Vet Med Sci 2022 Nov;8(6):2337-2344. Epub 2022 Sep 5 doi: 10.1002/vms3.930. PMID: 36063539Free PMC Article
Unusual evolution of leiomyosarcoma of the rectum: a case report and review of the literature.
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Benign and malignant tumors of the rectum and perirectal region.
Purysko AS, Coppa CP, Kalady MF, Pai RK, Leão Filho HM, Thupili CR, Remer EM
Abdom Imaging 2014 Aug;39(4):824-52. doi: 10.1007/s00261-014-0119-8. PMID: 24663381
Epidemiology of AIDS-related malignancies an international perspective.
Mbulaiteye SM, Parkin DM, Rabkin CS
Hematol Oncol Clin North Am 2003 Jun;17(3):673-96, v. doi: 10.1016/s0889-8588(03)00048-0. PMID: 12852650
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608

Diagnosis

Laparoscopic Management of Disseminated Peritoneal Leiomyomatosis.
Kriplani I, Kriplani A, Sharma S, Sodhi M, Jain N
J Minim Invasive Gynecol 2023 Jun;30(6):443-444. Epub 2023 Mar 17 doi: 10.1016/j.jmig.2023.03.006. PMID: 36934877
Giant multilocular prostatic cystadenoma.
Nakamura Y, Shida D, Shibayama T, Yoshida A, Matsui Y, Shinoda Y, Iwata S, Kanemitsu Y
World J Surg Oncol 2019 Feb 26;17(1):42. doi: 10.1186/s12957-019-1579-7. PMID: 30808350Free PMC Article
Schwannoma of the colon and rectum: a systematic literature review.
Bohlok A, El Khoury M, Bormans A, Galdon MG, Vouche M, El Nakadi I, Donckier V, Liberale G
World J Surg Oncol 2018 Jul 3;16(1):125. doi: 10.1186/s12957-018-1427-1. PMID: 29970075Free PMC Article
Benign and malignant tumors of the rectum and perirectal region.
Purysko AS, Coppa CP, Kalady MF, Pai RK, Leão Filho HM, Thupili CR, Remer EM
Abdom Imaging 2014 Aug;39(4):824-52. doi: 10.1007/s00261-014-0119-8. PMID: 24663381
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608

Therapy

Rectal leiomyosarcoma: a rare and long-term complication of radiation therapy.
Futuri S, Donohoe K, Spaccavento C, Yudelman I
BMJ Case Rep 2014 Oct 14;2014 doi: 10.1136/bcr-2014-205240. PMID: 25315801Free PMC Article
Histologic analysis of the irradiated anal sphincter.
Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Connor JT, Gervaz P
Dis Colon Rectum 2003 Nov;46(11):1492-7. doi: 10.1007/s10350-004-6800-1. PMID: 14605568
Sphincter preservation of leiomyosarcoma of the rectum and anus with local excision and brachytherapy.
Grann A, Paty PB, Guillem JG, Cohen AM, Minsky BD
Dis Colon Rectum 1999 Oct;42(10):1296-9. doi: 10.1007/BF02234218. PMID: 10528767
Conservative management of anal leiomyosarcoma.
Minsky BD, Cohen AM, Hajdu SI
Cancer 1991 Oct 1;68(7):1640-3. doi: 10.1002/1097-0142(19911001)68:7<1640::aid-cncr2820680729>3.0.co;2-6. PMID: 1893364
Primary leiomyosarcoma of the rectum: report of two cases and review of the literature.
Plukker JT, Blomjous EM, Wagstaff J, Meijer S
Neth J Surg 1989 Aug;41(4):88-91. PMID: 2674773

Prognosis

Schwannoma of the colon and rectum: a systematic literature review.
Bohlok A, El Khoury M, Bormans A, Galdon MG, Vouche M, El Nakadi I, Donckier V, Liberale G
World J Surg Oncol 2018 Jul 3;16(1):125. doi: 10.1186/s12957-018-1427-1. PMID: 29970075Free PMC Article
Unusual evolution of leiomyosarcoma of the rectum: a case report and review of the literature.
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Management of less common tumors of the colon, rectum, and anus.
Cuffy M, Abir F, Longo WE
Clin Colorectal Cancer 2006 Jan;5(5):327-37. doi: 10.3816/CCC.2006.n.002. PMID: 16512991
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608
Leiomyosarcoma of the rectum.
Asbun J, Asbun HJ, Padilla A, Lang A, Bloch J
Am Surg 1992 May;58(5):311-4. PMID: 1622013

Clinical prediction guides

Endoscopic ultrasound-guided fine-needle aspiration cytology in the diagnosis of leiomyomas of the gastrointestinal tract.
Val-Bernal JF, Martino M, Terán A, Yllera E, Castro-Senosiain B
Rev Esp Patol 2019 Jul-Sep;52(3):154-162. Epub 2018 Dec 4 doi: 10.1016/j.patol.2018.09.003. PMID: 31213256
Outcomes of Primary Colorectal Sarcoma: A National Cancer Data Base (NCDB) Review.
Thiels CA, Bergquist JR, Krajewski AC, Lee HE, Nelson H, Mathis KL, Habermann EB, Cima RR
J Gastrointest Surg 2017 Mar;21(3):560-568. Epub 2017 Jan 17 doi: 10.1007/s11605-016-3347-0. PMID: 28097468
Leiomyosarcoma of the rectum. A report of two cases and review of the literature.
Zbar AP, Sokolowsky N, Sandiford N, Prussia PR
West Indian Med J 2004 Mar;53(2):122-5. PMID: 15199725
Histologic analysis of the irradiated anal sphincter.
Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, Vernava AM 3rd, Connor JT, Gervaz P
Dis Colon Rectum 2003 Nov;46(11):1492-7. doi: 10.1007/s10350-004-6800-1. PMID: 14605568
Novel immunohistochemical localization of 28,000 molecular-weight (Mr) calcium binding protein (calbindin-D28k) in enterochromaffin cells of the human appendix and neuroendocrine tumors (carcinoids and small-cell carcinomas) of the midgut and foregut.
Katsetos CD, Jami MM, Krishna L, Jackson R, Patchefsky AS, Cooper HS
Arch Pathol Lab Med 1994 Jun;118(6):633-9. PMID: 8204010

Recent systematic reviews

Leiomyosarcoma of the rectum: A systematic review of recent literature.
Annicchiarico A, Montali F, Baldinu M, Casali L, Virgilio E, Costi R
J Surg Oncol 2024 Feb;129(2):365-380. Epub 2023 Oct 10 doi: 10.1002/jso.27481. PMID: 37814590

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...