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Childhood ovarian yolk sac tumor

MedGen UID:
234136
•Concept ID:
C1332993
•
Neoplastic Process
Synonyms: Childhood Ovarian Endodermal Sinus Neoplasm; childhood ovarian endodermal sinus neoplasm; Childhood Ovarian Endodermal Sinus Tumor; childhood ovarian endodermal sinus tumor; childhood ovarian endodermal sinus tumour; Childhood Ovarian Yolk Sac Neoplasm; childhood ovarian yolk Sac neoplasm; Childhood Ovarian Yolk Sac Tumor; childhood ovarian yolk sac tumor; ovary childhood endodermal sinus tumor; ovary childhood endodermal sinus tumour; paediatric ovarian endodermal sinus neoplasm; paediatric ovarian endodermal sinus tumour; paediatric ovarian yolk Sac neoplasm; paediatric ovarian yolk Sac tumour; Pediatric Ovarian Endodermal Sinus Neoplasm; pediatric ovarian endodermal sinus neoplasm; Pediatric Ovarian Endodermal Sinus Tumor; pediatric ovarian endodermal sinus tumor; Pediatric Ovarian Yolk Sac Neoplasm; pediatric ovarian yolk Sac neoplasm; Pediatric Ovarian Yolk Sac Tumor; pediatric ovarian yolk Sac tumor
 
Monarch Initiative: MONDO:0003759

Definition

A yolk sac tumor that arises from the ovary and occurs in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood ovarian yolk sac tumor

Recent clinical studies

Etiology

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Genital bleeding in premenarcheal children.
Imai A, Horibe S, Tamaya T
Int J Gynaecol Obstet 1995 Apr;49(1):41-5. doi: 10.1016/0020-7292(94)02305-i. PMID: 9457983
Ovarian malignancies in childhood and adolescence.
Major T, Borsos A, Lampé L, Juhász B
Eur J Obstet Gynecol Reprod Biol 1995 Nov;63(1):65-8. doi: 10.1016/0301-2115(95)02231-u. PMID: 8674568
Gynecologic tumors and symptoms in childhood and adolescence; 10-years' experience.
Imai A, Furui T, Tamaya T
Int J Gynaecol Obstet 1994 Jun;45(3):227-34. doi: 10.1016/0020-7292(94)90247-x. PMID: 7926241

Diagnosis

An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array.
Tamura D, Maeda D, Sato T, Sugawara T, Shirasawa H, Shimizu D, Sato N, Goto A, Terada Y
Genes Chromosomes Cancer 2020 Mar;59(3):209-213. Epub 2019 Nov 4 doi: 10.1002/gcc.22817. PMID: 31631430
Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Ovarian malignancies in childhood and adolescence.
Major T, Borsos A, Lampé L, Juhász B
Eur J Obstet Gynecol Reprod Biol 1995 Nov;63(1):65-8. doi: 10.1016/0301-2115(95)02231-u. PMID: 8674568
Gynecologic tumors and symptoms in childhood and adolescence; 10-years' experience.
Imai A, Furui T, Tamaya T
Int J Gynaecol Obstet 1994 Jun;45(3):227-34. doi: 10.1016/0020-7292(94)90247-x. PMID: 7926241

Therapy

The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol.
Göbel U, Calaminus G, Schneider DT, Koch S, Teske C, Harms D
Klin Padiatr 2006 Nov-Dec;218(6):309-14. doi: 10.1055/s-2006-942275. PMID: 17080332
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Multiple primary cancers in patients with osteosarcoma: influence of anticancer drugs and genetic factors.
Yonemoto T, Tatezaki S, Ishii T, Hagiwara Y, Inoue M
Am J Clin Oncol 2004 Jun;27(3):220-4. doi: 10.1097/01.coc.0000054534.43117.76. PMID: 15170137
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455
Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin.
Frazier AL, Grier HE, Green DM
Med Pediatr Oncol 1996 Aug;27(2):69-73. doi: 10.1002/(SICI)1096-911X(199608)27:2<69::AID-MPO1>3.0.CO;2-R. PMID: 8649322

Prognosis

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Imaging of ovarian teratomas in children: a 9-year review.
Alotaibi MO, Navarro OM
Can Assoc Radiol J 2010 Feb;61(1):23-8. doi: 10.1016/j.carj.2009.07.001. PMID: 19931379
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Genital bleeding in premenarcheal children.
Imai A, Horibe S, Tamaya T
Int J Gynaecol Obstet 1995 Apr;49(1):41-5. doi: 10.1016/0020-7292(94)02305-i. PMID: 9457983

Clinical prediction guides

Chromosomal gains of 12p and 1q are not associated with inferior outcome of pediatric and adolescent germ cell tumors.
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.
Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF
Int J Androl 2011 Aug;34(4 Pt 2):e218-33. Epub 2011 Jun 22 doi: 10.1111/j.1365-2605.2011.01186.x. PMID: 21696393Free PMC Article
The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol.
Göbel U, Calaminus G, Schneider DT, Koch S, Teske C, Harms D
Klin Padiatr 2006 Nov-Dec;218(6):309-14. doi: 10.1055/s-2006-942275. PMID: 17080332
Ovarian germ cell tumors in children: a clinical study of 66 patients.
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
Extracranial non-testicular teratoma in childhood and adolescence: introduction of a risk score for stratification of therapy.
Göbel U, Calaminus G, Blohm M, Booss D, Felberbauer F, Hofmann U, Holschneider AM, Willnow U, Harms D
Klin Padiatr 1997 Jul-Aug;209(4):228-34. doi: 10.1055/s-2008-1043955. PMID: 9293455

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