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Prostate Undifferentiated Carcinoma

MedGen UID:
234450
•Concept ID:
C1336863
•
Neoplastic Process
Synonyms: Undifferentiated Carcinoma of Prostate; Undifferentiated Carcinoma of the Prostate; Undifferentiated Prostate Carcinoma; Undifferentiated Prostatic Carcinoma

Definition

An invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Undifferentiated Carcinoma

Professional guidelines

PubMed

Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.
Lu Y, Tang H, Huang P, Wang J, Deng P, Li Y, Zheng J, Weng L
Int J Epidemiol 2022 Aug 10;51(4):1204-1218. doi: 10.1093/ije/dyac025. PMID: 35218345Free PMC Article
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487

Recent clinical studies

Etiology

Genomic and Evolutionary Characterization of Concurrent Intraductal Carcinoma and Adenocarcinoma of the Prostate.
Zhao J, Xu N, Zhu S, Nie L, Zhang M, Zheng L, Cai D, Sun X, Chen J, Dai J, Ni Y, Wang Z, Zhang X, Liang J, Chen Y, Hu X, Pan X, Yin X, Liu H, Zhao F, Zhang B, Chen H, Miao J, Qin C, Zhao X, Yao J, Liu Z, Liao B, Wei Q, Li X, Liu J, Gao AC, Huang H, Shen P, Chen N, Zeng H, Sun G
Cancer Res 2024 Jan 2;84(1):154-167. doi: 10.1158/0008-5472.CAN-23-1176. PMID: 37847513
De novo neuroendocrine features in prostate cancer.
Abdulfatah E, Fine SW, Lotan TL, Mehra R
Hum Pathol 2022 Sep;127:112-122. Epub 2022 Jul 8 doi: 10.1016/j.humpath.2022.07.002. PMID: 35810832
Intraductal Carcinoma of the Prostate: Pathogenesis and Molecular Perspectives.
Zong Y, Montironi R, Massari F, Jiang Z, Lopez-Beltran A, Wheeler TM, Scarpelli M, Santoni M, Cimadamore A, Cheng L
Eur Urol Focus 2021 Sep;7(5):955-963. Epub 2020 Oct 31 doi: 10.1016/j.euf.2020.10.007. PMID: 33132109
Premalignancy in Prostate Cancer: Rethinking What we Know.
De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG
Cancer Prev Res (Phila) 2016 Aug;9(8):648-56. Epub 2016 Jan 26 doi: 10.1158/1940-6207.CAPR-15-0431. PMID: 26813971
Prostate cancer and its mimics at multiparametric prostate MRI.
Yu J, Fulcher AS, Turner MA, Cockrell CH, Cote EP, Wallace TJ
Br J Radiol 2014 May;87(1037):20130659. Epub 2014 Mar 20 doi: 10.1259/bjr.20130659. PMID: 24646125Free PMC Article

Diagnosis

Cribriform Lesions of the Prostate Gland.
Cai Q, Shah RB
Surg Pathol Clin 2022 Dec;15(4):591-608. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.001. PMID: 36344177
Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Intraductal Carcinoma of the Prostate: A Guide for the Practicing Pathologist.
Varma M
Adv Anat Pathol 2021 Jul 1;28(4):276-287. doi: 10.1097/PAP.0000000000000303. PMID: 33990497
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Prostate cancer and its mimics at multiparametric prostate MRI.
Yu J, Fulcher AS, Turner MA, Cockrell CH, Cote EP, Wallace TJ
Br J Radiol 2014 May;87(1037):20130659. Epub 2014 Mar 20 doi: 10.1259/bjr.20130659. PMID: 24646125Free PMC Article

Therapy

Incidental prostate cancer after holmium laser enucleation of the prostate-A narrative review.
Yilmaz M, Toprak T, Suarez-Ibarrola R, Sigle A, Gratzke C, Miernik A
Andrologia 2022 Apr;54(3):e14332. Epub 2021 Nov 26 doi: 10.1111/and.14332. PMID: 34837229
Premalignancy in Prostate Cancer: Rethinking What we Know.
De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG
Cancer Prev Res (Phila) 2016 Aug;9(8):648-56. Epub 2016 Jan 26 doi: 10.1158/1940-6207.CAPR-15-0431. PMID: 26813971
Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation.
Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H, Huang J
Asian J Androl 2014 Jul-Aug;16(4):541-4. doi: 10.4103/1008-682X.123669. PMID: 24589459Free PMC Article
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA
Cancer Discov 2011 Nov;1(6):487-95. doi: 10.1158/2159-8290.CD-11-0130. PMID: 22389870Free PMC Article
Hormones and cancer: breast and prostate.
LeRoith D
Endocrinol Metab Clin North Am 2011 Sep;40(3):xiii-xvi. Epub 2011 Jun 12 doi: 10.1016/j.ecl.2011.05.015. PMID: 21889712

Prognosis

Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Large-Gland Proliferations of the Prostate.
Iczkowski KA
Surg Pathol Clin 2018 Dec;11(4):687-712. Epub 2018 Oct 17 doi: 10.1016/j.path.2018.07.001. PMID: 30447836
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604
Intraductal carcinoma of the prostate.
Robinson B, Magi-Galluzzi C, Zhou M
Arch Pathol Lab Med 2012 Apr;136(4):418-25. doi: 10.5858/arpa.2011-0519-RA. PMID: 22458904

Clinical prediction guides

Endocrine and paracrine characteristics of neuroendocrine prostate cancer.
Arman T, Nelson PS
Front Endocrinol (Lausanne) 2022;13:1012005. Epub 2022 Nov 11 doi: 10.3389/fendo.2022.1012005. PMID: 36440195Free PMC Article
Evanescent Prostate Carcinoma, Case Report.
Borja Menéndez DA, Borja Menéndez KA, Parra Rosero AC, Molina Herrera MC
Arch Esp Urol 2022 Aug;75(6):576-579. doi: 10.56434/j.arch.esp.urol.20227506.85. PMID: 36138509
Intraductal Carcinoma of the Prostate: A Guide for the Practicing Pathologist.
Varma M
Adv Anat Pathol 2021 Jul 1;28(4):276-287. doi: 10.1097/PAP.0000000000000303. PMID: 33990497
Intraductal carcinoma of the prostate: What we know and what we do not know.
Chen X, Ding B, Zhang P, Geng S, Xu J, Han B
Pathol Res Pract 2018 May;214(5):612-618. Epub 2018 Mar 6 doi: 10.1016/j.prp.2018.03.003. PMID: 29628124
Intraductal carcinoma of the prostate: a comprehensive and updated review.
Tsuzuki T
Int J Urol 2015 Feb;22(2):140-5. Epub 2014 Oct 31 doi: 10.1111/iju.12657. PMID: 25358604

Recent systematic reviews

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Adiposity and cancer survival: a systematic review and meta-analysis.
Cheng E, Kirley J, Cespedes Feliciano EM, Caan BJ
Cancer Causes Control 2022 Oct;33(10):1219-1246. Epub 2022 Aug 15 doi: 10.1007/s10552-022-01613-7. PMID: 35971021Free PMC Article
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysis.
Wu Z, Chen Q, Qu L, Li M, Wang L, Mir MC, Carbonara U, Pandolfo SD, Black PC, Paul AK, Di Lorenzo G, Porpiglia F, Mari A, Necchi A, Rouprêt M, Psutka SP, Autorino R
Eur Urol 2022 Apr;81(4):414-425. Epub 2022 Jan 31 doi: 10.1016/j.eururo.2022.01.028. PMID: 35101302
Systemic therapies for metastatic hormone-sensitive prostate cancer: network meta-analysis.
Mori K, Mostafaei H, Sari Motlagh R, Pradere B, Quhal F, Laukhtina E, Schuettfort VM, Kramer G, Abufaraj M, Karakiewicz PI, Kimura T, Egawa S, Shariat SF
BJU Int 2022 Apr;129(4):423-433. Epub 2021 Jul 21 doi: 10.1111/bju.15507. PMID: 34171173Free PMC Article
Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer.
Cavalheri V, Burtin C, Formico VR, Nonoyama ML, Jenkins S, Spruit MA, Hill K
Cochrane Database Syst Rev 2019 Jun 17;6(6):CD009955. doi: 10.1002/14651858.CD009955.pub3. PMID: 31204439Free PMC Article

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