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Benign Adrenal Cortical Neoplasm

MedGen UID:
234576
•Concept ID:
C1368669
•
Neoplastic Process
Synonyms: Benign Adrenal Cortex Neoplasm; Benign Adrenal Cortex Tumor; Benign neoplasm of adrenal cortex
SNOMED CT: Benign neoplasm of adrenal cortex (91966003)

Definition

A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Recent Updates on the Management of Adrenal Incidentalomas.
Park SS, Kim JH
Endocrinol Metab (Seoul) 2023 Aug;38(4):373-380. Epub 2023 Aug 16 doi: 10.3803/EnM.2023.1779. PMID: 37583083Free PMC Article
Management of Adrenal Tumors in Pediatric Patients.
Abib SCV, Weldon CB
Surg Oncol Clin N Am 2021 Apr;30(2):275-290. Epub 2021 Feb 3 doi: 10.1016/j.soc.2020.11.012. PMID: 33706900
Adrenocortical carcinoma: Impact of surgical treatment.
Mirallié E, Blanchard C, Caillard C, Rodien P, Briet C, Mucci S, Drui D, Hamy A
Ann Endocrinol (Paris) 2019 Nov;80(5-6):308-313. Epub 2019 Oct 18 doi: 10.1016/j.ando.2019.09.001. PMID: 31722787

Recent clinical studies

Etiology

Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study.
Jing Y, Hu J, Luo R, Mao Y, Luo Z, Zhang M, Yang J, Song Y, Feng Z, Wang Z, Cheng Q, Ma L, Yang Y, Zhong L, Du Z, Wang Y, Luo T, He W, Sun Y, Lv F, Li Q, Yang S
Ann Intern Med 2022 Oct;175(10):1383-1391. Epub 2022 Sep 13 doi: 10.7326/M22-1619. PMID: 36095315
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Radiofrequency ablation treatment for aldosterone-producing adenomas.
Sacks BA, Sacks AC, Faintuch S
Curr Opin Endocrinol Diabetes Obes 2017 Jun;24(3):169-173. doi: 10.1097/MED.0000000000000329. PMID: 28248752
Radiology of the adrenal incidentalomas. Review of the literature.
Farrugia FA, Martikos G, Surgeon C, Tzanetis P, Misiakos E, Zavras N, Charalampopoulos A
Endocr Regul 2017 Jan 1;51(1):35-51. doi: 10.1515/enr-2017-0005. PMID: 28222025
Adrenal incidentalomas.
Aron D, Terzolo M, Cawood TJ
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):69-82. doi: 10.1016/j.beem.2011.06.012. PMID: 22305453

Diagnosis

Recent Updates on the Management of Adrenal Incidentalomas.
Park SS, Kim JH
Endocrinol Metab (Seoul) 2023 Aug;38(4):373-380. Epub 2023 Aug 16 doi: 10.3803/EnM.2023.1779. PMID: 37583083Free PMC Article
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Adrenal incidentalomas.
Aron D, Terzolo M, Cawood TJ
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):69-82. doi: 10.1016/j.beem.2011.06.012. PMID: 22305453
Adrenal imaging.
Blake MA, Cronin CG, Boland GW
AJR Am J Roentgenol 2010 Jun;194(6):1450-60. doi: 10.2214/AJR.10.4547. PMID: 20489083
Adrenal incidentalomas.
Bertherat J, Mosnier-Pudar H, Bertagna X
Curr Opin Oncol 2002 Jan;14(1):58-63. doi: 10.1097/00001622-200201000-00011. PMID: 11790982

Therapy

Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Minimally invasive adrenal surgery: virtue or vice?
Winoker JS, Ahlborn DT, Omidele OO, Fernandez-Ranvier G, Derweesh IH, Mehrazin R
Future Oncol 2018 Feb;14(3):267-276. Epub 2018 Jan 18 doi: 10.2217/fon-2017-0420. PMID: 29345155
Adrenal incidentalomas.
Aron D, Terzolo M, Cawood TJ
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):69-82. doi: 10.1016/j.beem.2011.06.012. PMID: 22305453
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Cushing's syndrome.
Howlett TA, Rees LH, Besser GM
Clin Endocrinol Metab 1985 Nov;14(4):911-45. doi: 10.1016/s0300-595x(85)80083-9. PMID: 3002679

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Adrenocortical carcinoma: Impact of surgical treatment.
Mirallié E, Blanchard C, Caillard C, Rodien P, Briet C, Mucci S, Drui D, Hamy A
Ann Endocrinol (Paris) 2019 Nov;80(5-6):308-313. Epub 2019 Oct 18 doi: 10.1016/j.ando.2019.09.001. PMID: 31722787
Genetics of adrenocortical tumours.
Åkerström T, Carling T, Beuschlein F, Hellman P
J Intern Med 2016 Dec;280(6):540-550. doi: 10.1111/joim.12452. PMID: 27864864
Multiple endocrine neoplasms.
Falchetti A, Marini F, Luzi E, Tonelli F, Brandi ML
Best Pract Res Clin Rheumatol 2008 Mar;22(1):149-63. doi: 10.1016/j.berh.2007.11.010. PMID: 18328987
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Genetics of tumors of the adrenal cortex.
Bonnet-Serrano F, Bertherat J
Endocr Relat Cancer 2018 Mar;25(3):R131-R152. Epub 2017 Dec 12 doi: 10.1530/ERC-17-0361. PMID: 29233839
Current and emerging therapies for adrenocortical carcinoma--review.
Przytulska J, Rogala N, Bednarek-Tupikowska G
Adv Clin Exp Med 2015 Mar-Apr;24(2):185-93. doi: 10.17219/acem/30645. PMID: 25931348
The indeterminate adrenal mass.
Harrison B
Langenbecks Arch Surg 2012 Feb;397(2):147-54. Epub 2011 Sep 23 doi: 10.1007/s00423-011-0845-0. PMID: 21947480
Adrenal incidentalomas.
Bertherat J, Mosnier-Pudar H, Bertagna X
Curr Opin Oncol 2002 Jan;14(1):58-63. doi: 10.1097/00001622-200201000-00011. PMID: 11790982

Recent systematic reviews

Discrepancies in the Recommended Management of Adrenal Incidentalomas by Various Guidelines.
Maas M, Nassiri N, Bhanvadia S, Carmichael JD, Duddalwar V, Daneshmand S
J Urol 2021 Jan;205(1):52-59. Epub 2020 Aug 28 doi: 10.1097/JU.0000000000001342. PMID: 32856984
Interventions for infantile haemangiomas of the skin.
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article
Propranolol versus corticosteroids: what should be the treatment of choice in infantile hemangiomas?
Theunissen CI, Smitt JH, van der Horst CM
Ann Plast Surg 2015 Feb;74(2):237-41. doi: 10.1097/SAP.0b013e318299cd4e. PMID: 24051459
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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