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Adenocarcinoma In Situ in Tubular Adenoma

MedGen UID:
235114
•Concept ID:
C1377632
•
Neoplastic Process
Synonym: Adenocarcinoma in situ in tubular adenoma
SNOMED CT: Adenocarcinoma in situ in tubular adenoma (60286009)

Definition

An intraepithelial adenocarcinoma arising from a tubular adenoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma In Situ in Tubular Adenoma

Recent clinical studies

Etiology

Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53, and c-Myc as Alternative Mechanisms of Carcinogenesis.
Cox AJ, Crowe WE, Yang Q, Zhang B, Oltvai ZN, Liao X
Mod Pathol 2023 Nov;36(11):100295. Epub 2023 Jul 29 doi: 10.1016/j.modpat.2023.100295. PMID: 37517480
Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases.
Zhang Y, Kong YY, Cai X, Shen XX, Kong JC
J Cutan Pathol 2017 Jun;44(6):538-543. Epub 2017 Apr 17 doi: 10.1111/cup.12934. PMID: 28337777
Early changes in carcinogenesis of colorectal adenomas.
Toru S, Bilezikçi B
West Indian Med J 2012 Jan;61(1):10-6. doi: 10.7727/wimj.2011.136. PMID: 22808560
The frequency of advanced adenoma in consulting patients: a nationwide survey in Iceland (2003-2006).
Rubio CA, Kristjansdottir S, Thodleifsson B, Olafsdóttir E, Jonasson JG
Colorectal Dis 2012 Sep;14(9):e595-602. doi: 10.1111/j.1463-1318.2012.03119.x. PMID: 22672531
Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ.
Lee CH, Bang SH, Lee SK, Song KY, Lee IC
World J Gastroenterol 2005 Apr 7;11(13):1937-45. doi: 10.3748/wjg.v11.i13.1937. PMID: 15800983Free PMC Article

Diagnosis

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma.
Kryvenko ON, Wasco MJ, Williamson SR
Arch Pathol Lab Med 2022 May 1;147(5):552-558. doi: 10.5858/arpa.2021-0620-OA. PMID: 35976666
Perianal Paget's disease as spread from non-invasive colorectal adenomas.
Hutchings D, Windon A, Assarzadegan N, Salimian KJ, Voltaggio L, Montgomery EA
Histopathology 2021 Jan;78(2):276-280. Epub 2020 Sep 23 doi: 10.1111/his.14218. PMID: 32705713Free PMC Article
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Tubular adenoma and intramucosal intestinal-type adenocarcinoma of the stomach: what are the pathobiological differences?
Kase S, Osaki M, Honjo S, Adachi H, Ito H
Gastric Cancer 2003;6(2):71-9. doi: 10.1007/s10120-002-0210-7. PMID: 12861397
Computer-assisted pathology of intraepithelial adenocarcinoma and related lesions: 3-D distribution, structural aberration and discrimination.
Takahashi T, Chiba R, Mori M, Furukawa T, Suzuki M, Tezuka F
J Cell Biochem Suppl 1995;23:25-32. doi: 10.1002/jcb.240590905. PMID: 8747375

Prognosis

Perianal Paget's disease as spread from non-invasive colorectal adenomas.
Hutchings D, Windon A, Assarzadegan N, Salimian KJ, Voltaggio L, Montgomery EA
Histopathology 2021 Jan;78(2):276-280. Epub 2020 Sep 23 doi: 10.1111/his.14218. PMID: 32705713Free PMC Article
Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases.
Zhang Y, Kong YY, Cai X, Shen XX, Kong JC
J Cutan Pathol 2017 Jun;44(6):538-543. Epub 2017 Apr 17 doi: 10.1111/cup.12934. PMID: 28337777
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
The frequency of advanced adenoma in consulting patients: a nationwide survey in Iceland (2003-2006).
Rubio CA, Kristjansdottir S, Thodleifsson B, Olafsdóttir E, Jonasson JG
Colorectal Dis 2012 Sep;14(9):e595-602. doi: 10.1111/j.1463-1318.2012.03119.x. PMID: 22672531
Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patients.
Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS
Cancer 2002 Jan 1;94(1):62-77. doi: 10.1002/cncr.10203. PMID: 11815961

Clinical prediction guides

Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression.
Perilli L, Vicentini C, Agostini M, Pizzini S, Pizzi M, D'Angelo E, Bortoluzzi S, Mandruzzato S, Mammano E, Rugge M, Nitti D, Scarpa A, Fassan M, Zanovello P
Oncotarget 2014 Aug 30;5(16):6611-9. doi: 10.18632/oncotarget.2245. PMID: 25115394Free PMC Article
The frequency of advanced adenoma in consulting patients: a nationwide survey in Iceland (2003-2006).
Rubio CA, Kristjansdottir S, Thodleifsson B, Olafsdóttir E, Jonasson JG
Colorectal Dis 2012 Sep;14(9):e595-602. doi: 10.1111/j.1463-1318.2012.03119.x. PMID: 22672531
Association of large serrated polyps with synchronous advanced colorectal neoplasia.
Li D, Jin C, McCulloch C, Kakar S, Berger BM, Imperiale TF, Terdiman JP
Am J Gastroenterol 2009 Mar;104(3):695-702. Epub 2009 Feb 17 doi: 10.1038/ajg.2008.166. PMID: 19223889
Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases.
Seidel G, Zahurak M, Iacobuzio-Donahue C, Sohn TA, Adsay NV, Yeo CJ, Lillemoe KD, Cameron JL, Hruban RH, Wilentz RE
Am J Surg Pathol 2002 Jan;26(1):56-63. doi: 10.1097/00000478-200201000-00006. PMID: 11756769
Computer-assisted pathology of intraepithelial adenocarcinoma and related lesions: 3-D distribution, structural aberration and discrimination.
Takahashi T, Chiba R, Mori M, Furukawa T, Suzuki M, Tezuka F
J Cell Biochem Suppl 1995;23:25-32. doi: 10.1002/jcb.240590905. PMID: 8747375

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