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Hyaline Membrane Syndrome

MedGen UID:
235180
•Concept ID:
C1334061
•
Disease or Syndrome

Definition

A serious disorder affecting newborns, particularly premature infants. It is caused by deficiency of surfactant, resulting in the formation of a membrane in the alveoli lining. This membrane contains fibrin and cellular debris and interferes with respiration. Infants with this disorder develop breathing problems immediately or in a few hours after delivery. It may lead to respiratory failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyaline Membrane Syndrome

Recent clinical studies

Etiology

Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy: reassessment in relation to the causes of death.
Zhu BL, Ishida K, Quan L, Fujita MQ, Maeda H
Forensic Sci Int 2000 Sep 11;113(1-3):193-7. doi: 10.1016/s0379-0738(00)00264-4. PMID: 10978624

Diagnosis

Neuropathological and anatomopathological analyses of acardiac and "normal" siblings in an acardiac-twin pregnancy.
Kosno-Kruszewska E, Deregowski K, Schmidt-Sidor B, Wierzba-Bobrowicz T, Pawłowska B, Lechowicz W, Szpak GM, Lewandowska E, Bertrand E, Bogusławska R, Tomankiewicz-Zawadzka A
Folia Neuropathol 2003;41(2):103-9. PMID: 12899203
DIAGNOSIS AND TREATMENT: HYALINE MEMBRANE SYNDROME.
SMITH CA
Pediatrics 1965 Aug;36:257-60. PMID: 14320036
DIAGNOSIS AND TREATMENT OF THE HYALINE MEMBRANE SYNDROME AND MANAGEMENT OF THE NEWBORN BABY OF THE DIABETIC MOTHER.
CLELAND WD Jr
J Mich State Med Soc 1963 Dec;62:1198-200. PMID: 14088940

Prognosis

Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy: reassessment in relation to the causes of death.
Zhu BL, Ishida K, Quan L, Fujita MQ, Maeda H
Forensic Sci Int 2000 Sep 11;113(1-3):193-7. doi: 10.1016/s0379-0738(00)00264-4. PMID: 10978624
3-Methylhistidine/creatinine ratio in urine from low-birth-weight infants. Clinical approach.
Hülsemann J, Kordass U, Sander G, Schmidt E, Schöch G
Ann Nutr Metab 1988;32(1):44-51. doi: 10.1159/000177391. PMID: 3355111
Heat injuries to the respiratory system.
Brinkmann B, Püschel K
Virchows Arch A Pathol Anat Histol 1978 Oct 3;379(4):299-311. doi: 10.1007/BF00464473. PMID: 151977

Clinical prediction guides

Immunohistochemistry of pulmonary surfactant apoprotein A in forensic autopsy: reassessment in relation to the causes of death.
Zhu BL, Ishida K, Quan L, Fujita MQ, Maeda H
Forensic Sci Int 2000 Sep 11;113(1-3):193-7. doi: 10.1016/s0379-0738(00)00264-4. PMID: 10978624
Distribution and number of Clara cells in the normal and disturbed development of the human fetal lung.
Barth PJ, Wolf M, Ramaswamy A
Pediatr Pathol 1994 Jul-Aug;14(4):637-51. doi: 10.3109/15513819409023338. PMID: 7971583
3-Methylhistidine/creatinine ratio in urine from low-birth-weight infants. Clinical approach.
Hülsemann J, Kordass U, Sander G, Schmidt E, Schöch G
Ann Nutr Metab 1988;32(1):44-51. doi: 10.1159/000177391. PMID: 3355111

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