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Localized Peripheral Primitive Neuroectodermal Tumor

MedGen UID:
235259
•Concept ID:
C1334408
•
Neoplastic Process

Definition

A small round cell tumor with neural differentiation, confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Peripheral Primitive Neuroectodermal Tumor

Professional guidelines

PubMed

Bispecific antibodies for the treatment of neuroblastoma.
Espinosa-Cotton M, Cheung NV
Pharmacol Ther 2022 Sep;237:108241. Epub 2022 Jul 10 doi: 10.1016/j.pharmthera.2022.108241. PMID: 35830901Free PMC Article
Management of Neuroblastoma in Pediatric Patients.
Croteau N, Nuchtern J, LaQuaglia MP
Surg Oncol Clin N Am 2021 Apr;30(2):291-304. Epub 2021 Feb 10 doi: 10.1016/j.soc.2020.11.010. PMID: 33706901
Overview and recent advances in the treatment of neuroblastoma.
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287

Recent clinical studies

Etiology

Advancing therapy for neuroblastoma.
Qiu B, Matthay KK
Nat Rev Clin Oncol 2022 Aug;19(8):515-533. Epub 2022 May 25 doi: 10.1038/s41571-022-00643-z. PMID: 35614230
Immunotherapy of Neuroblastoma: Facts and Hopes.
Anderson J, Majzner RG, Sondel PM
Clin Cancer Res 2022 Aug 2;28(15):3196-3206. doi: 10.1158/1078-0432.CCR-21-1356. PMID: 35435953Free PMC Article
Management of Neuroblastoma in Pediatric Patients.
Croteau N, Nuchtern J, LaQuaglia MP
Surg Oncol Clin N Am 2021 Apr;30(2):291-304. Epub 2021 Feb 10 doi: 10.1016/j.soc.2020.11.010. PMID: 33706901
Overview and recent advances in the treatment of neuroblastoma.
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Recent advances in neuroblastoma.
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article

Diagnosis

Cellular senescence in neuroblastoma.
Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F
Br J Cancer 2022 Jun;126(11):1529-1538. Epub 2022 Feb 23 doi: 10.1038/s41416-022-01755-0. PMID: 35197583Free PMC Article
Overview and recent advances in the treatment of neuroblastoma.
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527
Neuroblastoma.
Humpl T
World J Urol 1995;13(4):233-9. doi: 10.1007/BF00182969. PMID: 8528298
Esthesioneuroblastoma.
Shah JP, Feghali J
Am J Surg 1981 Oct;142(4):456-8. doi: 10.1016/0002-9610(81)90374-3. PMID: 7283046

Therapy

Advancing therapy for neuroblastoma.
Qiu B, Matthay KK
Nat Rev Clin Oncol 2022 Aug;19(8):515-533. Epub 2022 May 25 doi: 10.1038/s41571-022-00643-z. PMID: 35614230
Immunotherapy of Neuroblastoma: Facts and Hopes.
Anderson J, Majzner RG, Sondel PM
Clin Cancer Res 2022 Aug 2;28(15):3196-3206. doi: 10.1158/1078-0432.CCR-21-1356. PMID: 35435953Free PMC Article
Anti-GD2 CAR-NKT cells in patients with relapsed or refractory neuroblastoma: an interim analysis.
Heczey A, Courtney AN, Montalbano A, Robinson S, Liu K, Li M, Ghatwai N, Dakhova O, Liu B, Raveh-Sadka T, Chauvin-Fleurence CN, Xu X, Ngai H, Di Pierro EJ, Savoldo B, Dotti G, Metelitsa LS
Nat Med 2020 Nov;26(11):1686-1690. Epub 2020 Oct 12 doi: 10.1038/s41591-020-1074-2. PMID: 33046868
Anti-GD2 immunotherapy for neuroblastoma.
Sait S, Modak S
Expert Rev Anticancer Ther 2017 Oct;17(10):889-904. Epub 2017 Aug 14 doi: 10.1080/14737140.2017.1364995. PMID: 28780888Free PMC Article
Recent advances in neuroblastoma.
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article

Prognosis

Anti-GD2 immunotherapy for neuroblastoma.
Sait S, Modak S
Expert Rev Anticancer Ther 2017 Oct;17(10):889-904. Epub 2017 Aug 14 doi: 10.1080/14737140.2017.1364995. PMID: 28780888Free PMC Article
Overview and recent advances in the treatment of neuroblastoma.
Whittle SB, Smith V, Doherty E, Zhao S, McCarty S, Zage PE
Expert Rev Anticancer Ther 2017 Apr;17(4):369-386. Epub 2017 Mar 15 doi: 10.1080/14737140.2017.1285230. PMID: 28142287
Neuroblastoma.
Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, Weiss WA
Nat Rev Dis Primers 2016 Nov 10;2:16078. doi: 10.1038/nrdp.2016.78. PMID: 27830764
Recent advances in neuroblastoma.
Maris JM
N Engl J Med 2010 Jun 10;362(23):2202-11. doi: 10.1056/NEJMra0804577. PMID: 20558371Free PMC Article
Esthesioneuroblastoma.
Elkon D, Hightower SI, Lim ML, Cantrell RW, Constable WC
Cancer 1979 Sep;44(3):1087-94. doi: 10.1002/1097-0142(197909)44:3<1087::aid-cncr2820440343>3.0.co;2-a. PMID: 383268

Clinical prediction guides

Cellular senescence in neuroblastoma.
Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F
Br J Cancer 2022 Jun;126(11):1529-1538. Epub 2022 Feb 23 doi: 10.1038/s41416-022-01755-0. PMID: 35197583Free PMC Article
Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD-1 Checkpoint Blockade in Neuroblastoma.
Su Y, Luo B, Lu Y, Wang D, Yan J, Zheng J, Xiao J, Wang Y, Xue Z, Yin J, Chen P, Li L, Zhao Q
Clin Cancer Res 2022 Feb 15;28(4):793-809. doi: 10.1158/1078-0432.CCR-21-2241. PMID: 34844980Free PMC Article
Management of Neuroblastoma in Pediatric Patients.
Croteau N, Nuchtern J, LaQuaglia MP
Surg Oncol Clin N Am 2021 Apr;30(2):291-304. Epub 2021 Feb 10 doi: 10.1016/j.soc.2020.11.010. PMID: 33706901
Neuroblastoma: clinical and biological approach to risk stratification and treatment.
Tolbert VP, Matthay KK
Cell Tissue Res 2018 May;372(2):195-209. Epub 2018 Mar 23 doi: 10.1007/s00441-018-2821-2. PMID: 29572647Free PMC Article
Neuroblastoma.
Davidoff AM
Semin Pediatr Surg 2012 Feb;21(1):2-14. doi: 10.1053/j.sempedsurg.2011.10.009. PMID: 22248965Free PMC Article

Recent systematic reviews

Lymph node metastasis from olfactory neuroblastoma at presentation and as disease relapse: A systematic review and proportion meta-analysis of prevalence data and variables influencing regional control.
Tomasoni M, Marazzi E, Rampinelli V, Mattavelli D, Schreiber A, Deganello A, Piazza C
Head Neck 2023 Jun;45(6):1486-1496. Epub 2023 Mar 30 doi: 10.1002/hed.27361. PMID: 36995898
Ophthalmologic Manifestations of Neuroblastoma: A Systemic Review.
Kuchalska K, Derwich K, Gotz-Więckowska A
J Pediatr Hematol Oncol 2023 Mar 1;45(2):47-56. Epub 2022 Sep 13 doi: 10.1097/MPH.0000000000002543. PMID: 36161977
Primary Intracranial pPNET/Ewing Sarcoma: Diagnosis, Management, and Prognostic Factors Dilemma-A Systematic Review of the Literature.
Cherif El Asri A, Benzagmout M, Chakour K, Chaoui MF, Laaguili J, Chahdi H, Gazzaz M, El Mostarchid B
World Neurosurg 2018 Jul;115:346-356. Epub 2018 May 3 doi: 10.1016/j.wneu.2018.04.164. PMID: 29729469
Endoscopic endonasal compared with anterior craniofacial and combined cranionasal resection of esthesioneuroblastomas.
Komotar RJ, Starke RM, Raper DM, Anand VK, Schwartz TH
World Neurosurg 2013 Jul-Aug;80(1-2):148-59. Epub 2012 Dec 7 doi: 10.1016/j.wneu.2012.12.003. PMID: 23228365
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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