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Methotrexate-Associated Diffuse Large B-Cell Lymphoma

MedGen UID:
235324
•Concept ID:
C1334746
•
Neoplastic Process

Definition

A diffuse large B-cell lymphoma that develops in patients who are immunosuppressed with methotrexate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMethotrexate-Associated Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Spontaneous remission of "methotrexate-associated lymphoproliferative disorders" after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature.
Rizzi R, Curci P, Delia M, Rinaldi E, Chiefa A, Specchia G, Liso V
Med Oncol 2009;26(1):1-9. Epub 2008 May 7 doi: 10.1007/s12032-008-9069-8. PMID: 18461290

Recent clinical studies

Etiology

Programmed cell death-ligand 1 (PD-L1)(+) tumour cells and low-reacting programmed cell death 1 (PD1)(+) tumour-infiltrating lymphocytes predict poor prognosis in Epstein-Barr virus(+) diffuse large B-cell lymphoma.
Kimura S, Oshiro Y, Iwasaki H, Kadowaki M, Mihashi Y, Sakata T, Kawauchi S, Wang Z, Takamatsu Y, Takeshita M
Clin Exp Med 2022 Aug;22(3):411-419. Epub 2021 Sep 13 doi: 10.1007/s10238-021-00754-4. PMID: 34515880
Clinicopathologic Analysis of Primary Adrenal Diffuse Large B-Cell Lymphoma: A Reappraisal of 23 Japanese Patients Based on EBV Association and PD-L1 Expression in Tumor Cells.
Kawano T, Tsuyuki Y, Suzuki Y, Shimada K, Kato S, Takahara T, Mori M, Nakaguro M, Sakakibara A, Nakamura S, Satou A
Am J Surg Pathol 2021 Dec 1;45(12):1606-1615. doi: 10.1097/PAS.0000000000001809. PMID: 34534136
Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort.
Mishina T, Oshima-Hasegawa N, Tsukamoto S, Fukuyo M, Kageyama H, Muto T, Mimura N, Rahmutulla B, Nagai Y, Kayamori K, Hino Y, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Tsujimura H, Iseki T, Nakaseko C, Ikeda JI, Itami M, Yokote K, Ohara O, Kaneda A, Sakaida E
Br J Haematol 2021 Dec;195(5):731-742. Epub 2021 Aug 10 doi: 10.1111/bjh.17765. PMID: 34378195
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195

Diagnosis

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195
Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer.
Moriya K, Kikuti YY, Carreras J, Kondo Y, Shiraiwa S, Nakamura N
J Clin Exp Hematop 2020;60(1):11-16. doi: 10.3960/jslrt.19038. PMID: 32224560Free PMC Article
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
Carreras J, Yukie Kikuti Y, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Shiraiwa S, Ando K, Sato S, Suzuki Y, Miura I, Roncador G, Nakamura N
Am J Surg Pathol 2018 Jul;42(7):936-950. doi: 10.1097/PAS.0000000000001071. PMID: 29738359
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis.
Kikuchi J, Kaneko Y, Kasahara H, Emoto K, Kubo A, Okamoto S, Takeuchi T
Intern Med 2016;55(12):1661-5. Epub 2016 Jun 15 doi: 10.2169/internalmedicine.55.6943. PMID: 27301524

Therapy

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer.
Moriya K, Kikuti YY, Carreras J, Kondo Y, Shiraiwa S, Nakamura N
J Clin Exp Hematop 2020;60(1):11-16. doi: 10.3960/jslrt.19038. PMID: 32224560Free PMC Article
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
Carreras J, Yukie Kikuti Y, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Shiraiwa S, Ando K, Sato S, Suzuki Y, Miura I, Roncador G, Nakamura N
Am J Surg Pathol 2018 Jul;42(7):936-950. doi: 10.1097/PAS.0000000000001071. PMID: 29738359
Clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: Comparison of diffuse large B-cell lymphoma and classical Hodgkin lymphoma types.
Gion Y, Iwaki N, Takata K, Takeuchi M, Nishida K, Orita Y, Tachibana T, Yoshino T, Sato Y
Cancer Sci 2017 Jun;108(6):1271-1280. Epub 2017 May 23 doi: 10.1111/cas.13249. PMID: 28380678Free PMC Article
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis.
Kikuchi J, Kaneko Y, Kasahara H, Emoto K, Kubo A, Okamoto S, Takeuchi T
Intern Med 2016;55(12):1661-5. Epub 2016 Jun 15 doi: 10.2169/internalmedicine.55.6943. PMID: 27301524

Prognosis

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort.
Mishina T, Oshima-Hasegawa N, Tsukamoto S, Fukuyo M, Kageyama H, Muto T, Mimura N, Rahmutulla B, Nagai Y, Kayamori K, Hino Y, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Tsujimura H, Iseki T, Nakaseko C, Ikeda JI, Itami M, Yokote K, Ohara O, Kaneda A, Sakaida E
Br J Haematol 2021 Dec;195(5):731-742. Epub 2021 Aug 10 doi: 10.1111/bjh.17765. PMID: 34378195
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
Carreras J, Yukie Kikuti Y, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Shiraiwa S, Ando K, Sato S, Suzuki Y, Miura I, Roncador G, Nakamura N
Am J Surg Pathol 2018 Jul;42(7):936-950. doi: 10.1097/PAS.0000000000001071. PMID: 29738359
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis.
Kikuchi J, Kaneko Y, Kasahara H, Emoto K, Kubo A, Okamoto S, Takeuchi T
Intern Med 2016;55(12):1661-5. Epub 2016 Jun 15 doi: 10.2169/internalmedicine.55.6943. PMID: 27301524
EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate.
Hsiao SC, Ichinohasama R, Lin SH, Liao YL, Chang ST, Cho CY, Chuang SS
Pathol Res Pract 2009;205(1):43-9. Epub 2008 Oct 31 doi: 10.1016/j.prp.2008.08.006. PMID: 18951733

Clinical prediction guides

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Programmed cell death-ligand 1 (PD-L1)(+) tumour cells and low-reacting programmed cell death 1 (PD1)(+) tumour-infiltrating lymphocytes predict poor prognosis in Epstein-Barr virus(+) diffuse large B-cell lymphoma.
Kimura S, Oshiro Y, Iwasaki H, Kadowaki M, Mihashi Y, Sakata T, Kawauchi S, Wang Z, Takamatsu Y, Takeshita M
Clin Exp Med 2022 Aug;22(3):411-419. Epub 2021 Sep 13 doi: 10.1007/s10238-021-00754-4. PMID: 34515880
Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort.
Mishina T, Oshima-Hasegawa N, Tsukamoto S, Fukuyo M, Kageyama H, Muto T, Mimura N, Rahmutulla B, Nagai Y, Kayamori K, Hino Y, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Tsujimura H, Iseki T, Nakaseko C, Ikeda JI, Itami M, Yokote K, Ohara O, Kaneda A, Sakaida E
Br J Haematol 2021 Dec;195(5):731-742. Epub 2021 Aug 10 doi: 10.1111/bjh.17765. PMID: 34378195
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195

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