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Reactive cutaneous fibrous lesion

MedGen UID:
235529
•Concept ID:
C1335666
•
Disease or Syndrome
Synonyms: Reactive Cutaneous Fibrous Lesion; reactive cutaneous fibrous lesion
 
Monarch Initiative: MONDO:0006603

Definition

A benign, epidermal skin lesion characterized by overexpression of collagen during wound healing. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive cutaneous fibrous lesion

Recent clinical studies

Etiology

Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations.
Giannoni M, Rizzetto G, Diotallevi F, Molinelli E, Radi G, Campanati A, Brancorsni D, Offidani A
Acta Dermatovenerol Croat 2022 Sep;30(2):123-125. PMID: 36254548
Solitary fibrous tumors of the skin: a clinicopathologic study of 10 cases and review of the literature.
Erdag G, Qureshi HS, Patterson JW, Wick MR
J Cutan Pathol 2007 Nov;34(11):844-50. doi: 10.1111/j.1600-0560.2006.00728.x. PMID: 17944724
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169
Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: a report of the CHAMP study group.
Vanni R, Fletcher CD, Sciot R, Dal Cin P, De Wever I, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Tallini G, Van Den Berghe H, Willén H
Histopathology 2000 Sep;37(3):212-7. doi: 10.1046/j.1365-2559.2000.00947.x. PMID: 10971696
Benign cutaneous histiocytic tumors in childhood and adolescence, excluding Langerhans' cell proliferations. A clinicopathologic and immunohistochemical analysis.
Marrogi AJ, Dehner LP, Coffin CM, Wick MR
Am J Dermatopathol 1992 Feb;14(1):8-18. doi: 10.1097/00000372-199202000-00002. PMID: 1324624

Diagnosis

Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations.
Giannoni M, Rizzetto G, Diotallevi F, Molinelli E, Radi G, Campanati A, Brancorsni D, Offidani A
Acta Dermatovenerol Croat 2022 Sep;30(2):123-125. PMID: 36254548
Oral focal mucinosis: A multi-institutional study and literature review.
Silva Cunha JL, Leite AA, de Castro Abrantes T, Vervloet LP, de Lima Morais TM, de Oliveira Paiva Neto G, Kimura TNL, Ferreira SMS, de Albuquerque-Júnior RLC, Abrahão AC, Romañach MJ, Benevenuto de Andrade BA, de Almeida OP, Soares CD
J Cutan Pathol 2021 Jan;48(1):24-33. Epub 2020 Sep 8 doi: 10.1111/cup.13813. PMID: 33410541
Diagnostic value of CD163 in cutaneous spindle cell lesions.
Pouryazdanparast P, Yu L, Cutlan JE, Olsen SH, Fullen DR, Ma L
J Cutan Pathol 2009 Aug;36(8):859-64. Epub 2009 Nov 24 doi: 10.1111/j.1600-0560.2008.01179.x. PMID: 19040468
Dermatofibroma-a critical evaluation.
Zelger B, Zelger BG, Burgdorf WH
Int J Surg Pathol 2004 Oct;12(4):333-44. doi: 10.1177/106689690401200406. PMID: 15494859
Myxoid dermatofibroma.
Zelger BG, Calonje E, Zelger B
Histopathology 1999 Apr;34(4):357-64. doi: 10.1046/j.1365-2559.1999.00633.x. PMID: 10231403

Therapy

Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations.
Giannoni M, Rizzetto G, Diotallevi F, Molinelli E, Radi G, Campanati A, Brancorsni D, Offidani A
Acta Dermatovenerol Croat 2022 Sep;30(2):123-125. PMID: 36254548
Primary cutaneous marginal zone lymphoma (immunocytoma like) with lymphoepithelioid or Lennert's lymphoma like involvement of nodes.
Shet T, Basak R, Epari S
Indian J Pathol Microbiol 2012 Apr-Jun;55(2):222-6. doi: 10.4103/0377-4929.97882. PMID: 22771649
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma).
Hui P, Glusac EJ, Sinard JH, Perkins AS
J Cutan Pathol 2002 Aug;29(7):385-9. doi: 10.1034/j.1600-0560.2002.290701.x. PMID: 12139632
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Prognosis

Presentation of an epithelioid cell histiocytoma on the ventral tongue.
Rawal YB, Kalmar JR, Shumway B, Mallery SR
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Jul;100(1):75-83. doi: 10.1016/j.tripleo.2005.01.017. PMID: 15953920
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169

Clinical prediction guides

Atypical Scleroderma-like Chronic GVHD in a Liver Transplant Patient, Clinical and MRI Correlations.
Giannoni M, Rizzetto G, Diotallevi F, Molinelli E, Radi G, Campanati A, Brancorsni D, Offidani A
Acta Dermatovenerol Croat 2022 Sep;30(2):123-125. PMID: 36254548
Diagnostic value of CD163 in cutaneous spindle cell lesions.
Pouryazdanparast P, Yu L, Cutlan JE, Olsen SH, Fullen DR, Ma L
J Cutan Pathol 2009 Aug;36(8):859-64. Epub 2009 Nov 24 doi: 10.1111/j.1600-0560.2008.01179.x. PMID: 19040468
Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma).
Hui P, Glusac EJ, Sinard JH, Perkins AS
J Cutan Pathol 2002 Aug;29(7):385-9. doi: 10.1034/j.1600-0560.2002.290701.x. PMID: 12139632
Atypical fibroxanthoma. Multiple immunohistologic profiles.
Longacre TA, Smoller BR, Rouse RV
Am J Surg Pathol 1993 Dec;17(12):1199-209. doi: 10.1097/00000478-199312000-00001. PMID: 8238729
Benign cutaneous histiocytic tumors in childhood and adolescence, excluding Langerhans' cell proliferations. A clinicopathologic and immunohistochemical analysis.
Marrogi AJ, Dehner LP, Coffin CM, Wick MR
Am J Dermatopathol 1992 Feb;14(1):8-18. doi: 10.1097/00000372-199202000-00002. PMID: 1324624

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