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Nasopharyngeal Squamous Papilloma

MedGen UID:
236846
•Concept ID:
C1336085
•
Neoplastic Process
Synonyms: Nasopharyngeal Papilloma; Nasopharyngeal Squamous Cell Papilloma; Nasopharynx Papilloma; Papilloma of Nasopharynx; Papilloma of the Nasopharynx; Squamous Papilloma of Nasopharynx; Squamous Papilloma of the Nasopharynx

Definition

A benign exophytic neoplasm that arises from the nasopharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Squamous Papilloma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection.
Gholami MD, Guppy-Coles K, Nihal S, Langguth D, Sonar P, Ayoko GA, Punyadeera C, Izake EL
Talanta 2022 Oct 1;248:123630. Epub 2022 May 31 doi: 10.1016/j.talanta.2022.123630. PMID: 35660992Free PMC Article
Implication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.
Kim D, Siegel J, Chouake RJ, Geliebter J, Zalvan CH
Ear Nose Throat J 2021 Aug;100(7):546-551. Epub 2019 Oct 3 doi: 10.1177/0145561319871228. PMID: 31581834

Recent clinical studies

Etiology

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
Oro- and Nasopharyngeal Papillomas with Squamous and Respiratory Features: A Case Series of Schneiderian-Like Papillomas of the Pharynx.
Ababneh EI, Shah AA
Head Neck Pathol 2022 Jun;16(2):486-493. Epub 2021 Oct 25 doi: 10.1007/s12105-021-01389-3. PMID: 34694538Free PMC Article
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204
Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis.
Murata M, Thanan R, Ma N, Kawanishi S
J Biomed Biotechnol 2012;2012:623019. Epub 2012 Jan 26 doi: 10.1155/2012/623019. PMID: 22363173Free PMC Article

Diagnosis

Head and neck carcinoma of unknown primary.
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204
Cancer-associated infectious agents and epigenetic regulation.
Vedham V, Verma M
Methods Mol Biol 2015;1238:333-54. doi: 10.1007/978-1-4939-1804-1_18. PMID: 25421669
Respiratory epithelial adenomatoid hamartoma: a review.
Fitzhugh VA, Mirani N
Head Neck Pathol 2008 Sep;2(3):203-8. Epub 2008 Jun 12 doi: 10.1007/s12105-008-0064-3. PMID: 20614315Free PMC Article

Therapy

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
Precision medicine in head and neck cancer.
Kaidar-Person O, Gil Z, Billan S
Drug Resist Updat 2018 Sep;40:13-16. Epub 2018 Sep 25 doi: 10.1016/j.drup.2018.09.001. PMID: 30466712
Proton therapy for head and neck cancer: expanding the therapeutic window.
Leeman JE, Romesser PB, Zhou Y, McBride S, Riaz N, Sherman E, Cohen MA, Cahlon O, Lee N
Lancet Oncol 2017 May;18(5):e254-e265. Epub 2017 Apr 26 doi: 10.1016/S1470-2045(17)30179-1. PMID: 28456587
Prevention of infection-related cancers in the WHO Western Pacific Region.
Shin HR, Shin A, Woo H, Fox K, Walsh N, Lo YR, Wiesen E, Varghese C
Jpn J Clin Oncol 2016 Jan;46(1):13-22. Epub 2015 Nov 12 doi: 10.1093/jjco/hyv092. PMID: 26563255
Combination antiangiogenic therapy and radiation in head and neck cancers.
Hsu HW, Wall NR, Hsueh CT, Kim S, Ferris RL, Chen CS, Mirshahidi S
Oral Oncol 2014 Jan;50(1):19-26. Epub 2013 Oct 23 doi: 10.1016/j.oraloncology.2013.10.003. PMID: 24269532

Prognosis

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Incidence and Prognosis of Brain Metastases in Head and Neck Cancer Patients at Diagnosis.
Messing I, Goyal S, Sherman JH, Thakkar P, Siegel R, Joshi A, Goodman J, Ojong-Ntui M, Rao YJ
Laryngoscope 2021 Sep;131(9):E2543-E2552. Epub 2021 Feb 18 doi: 10.1002/lary.29448. PMID: 33599979
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204

Clinical prediction guides

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century.
Koskinen AI, Hemminki O, Försti A, Hemminki K
BMC Cancer 2022 Mar 2;22(1):227. doi: 10.1186/s12885-022-09337-2. PMID: 35236321Free PMC Article
Histopathology of Sinonasal and Nasopharyngeal Neoplastic Lesions in a Tertiary Care Center of Western Nepal: A Descriptive Cross-sectional Study.
Regmi S, Ghosh A, Gharti Magar D, Thapa S, Koirala KP, Talwar OP
JNMA J Nepal Med Assoc 2021 Jul 30;59(239):657-662. doi: 10.31729/jnma.6859. PMID: 34508496Free PMC Article
Characteristics and Impact of HPV-Associated p16 Expression on Head and Neck Squamous Cell Carcinoma in Thai Patients.
Jiarpinitnun C, Larbcharoensub N, Pattaranutaporn P, Chureemas T, Juengsamarn J, Trachu N, Lukerak S, Chansriwong P, Ngamphaiboon N
Asian Pac J Cancer Prev 2020 Jun 1;21(6):1679-1687. doi: 10.31557/APJCP.2020.21.6.1679. PMID: 32592364Free PMC Article
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204
Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis.
Murata M, Thanan R, Ma N, Kawanishi S
J Biomed Biotechnol 2012;2012:623019. Epub 2012 Jan 26 doi: 10.1155/2012/623019. PMID: 22363173Free PMC Article

Recent systematic reviews

Risk of Virus Contamination Through Surgical Smoke During Minimally Invasive Surgery: A Systematic Review of the Literature on a Neglected Issue Revived in the COVID-19 Pandemic Era.
Pavan N, Crestani A, Abrate A, De Nunzio C, Esperto F, Giannarini G, Galfano A, Gregori A, Liguori G, Bartoletti R, Porpiglia F, Simonato A, Trombetta C, Tubaro A, Ficarra V, Novara G; Research Urology Network (RUN)
Eur Urol Focus 2020 Sep 15;6(5):1058-1069. Epub 2020 Jun 5 doi: 10.1016/j.euf.2020.05.021. PMID: 32527624Free PMC Article

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