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T-lymphoblastic lymphoma

MedGen UID:
266232
Concept ID:
C1292758
Neoplastic Process
Synonyms: Precur. T-lymphoblastic lymphoma; Precursor T Lymphoblastic Lymphoma; precursor T Lymphoblastic lymphoma; Precursor T-cell lymphoblastic lymphoma; Precursor T-Cell Lymphoblastic Lymphoma; precursor T-cell Lymphoblastic lymphoma; Precursor T-Lymphoblastic Lymphoma; precursor T-lymphoblastic lymphoma; precursor T-Lymphoblastic lymphoma; T Lymphoblastic Lymphoma; T Lymphoblastic lymphoma; T-Lymphoblastic Lymphoma; T-Lymphoblastic lymphoma
SNOMED CT: Precursor T-cell lymphoblastic lymphoma (128808004); Precursor T-cell lymphoblastic lymphoma (421246008)
 
Monarch Initiative: MONDO:0044917

Definition

The most frequent type of lymphoblastic lymphoma. It comprises approximately 85-90% of cases. It is more frequently seen in adolescent males. It frequently presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, 2001) [from NCI]

Professional guidelines

PubMed

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
Lepretre S, Graux C, Touzart A, Macintyre E, Boissel N
Exp Hematol 2017 Jul;51:7-16. Epub 2017 Apr 12 doi: 10.1016/j.exphem.2017.04.002. PMID: 28412288

Recent clinical studies

Etiology

Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Xu X, Paxton CN, Hayashi RJ, Dunsmore KP, Winter SS, Hunger SP, Winick NJ, Carroll WL, Loh ML, Devidas M, Gross TG, Bollard CM, Perkins SL, Miles RR
Blood Adv 2021 Jul 27;5(14):2890-2900. doi: 10.1182/bloodadvances.2021004334. PMID: 34297047Free PMC Article
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Teachey DT, O'Connor D
Blood 2020 Jan 16;135(3):159-166. doi: 10.1182/blood.2019001557. PMID: 31738819Free PMC Article
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article

Diagnosis

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Abaza Y, M Kantarjian H, Faderl S, Jabbour E, Jain N, Thomas D, Kadia T, Borthakur G, D Khoury J, Burger J, Wierda W, O'Brien S, Konopleva M, Ferrajoli A, Kebriaei P, Dabaja B, Kornblau S, Alvarado Y, Daver N, Pemmaraju N, Bose P, Thompson P, Al Azzawi H, Kelly M, Garris R, Jain P, Garcia-Manero G, Cortes J, Ravandi F
Am J Hematol 2018 Jan;93(1):91-99. Epub 2017 Nov 3 doi: 10.1002/ajh.24947. PMID: 29047158
You MJ, Medeiros LJ, Hsi ED
Am J Clin Pathol 2015 Sep;144(3):411-22. doi: 10.1309/AJCPMF03LVSBLHPJ. PMID: 26276771

Therapy

Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Teachey DT, O'Connor D
Blood 2020 Jan 16;135(3):159-166. doi: 10.1182/blood.2019001557. PMID: 31738819Free PMC Article
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article
Abaza Y, M Kantarjian H, Faderl S, Jabbour E, Jain N, Thomas D, Kadia T, Borthakur G, D Khoury J, Burger J, Wierda W, O'Brien S, Konopleva M, Ferrajoli A, Kebriaei P, Dabaja B, Kornblau S, Alvarado Y, Daver N, Pemmaraju N, Bose P, Thompson P, Al Azzawi H, Kelly M, Garris R, Jain P, Garcia-Manero G, Cortes J, Ravandi F
Am J Hematol 2018 Jan;93(1):91-99. Epub 2017 Nov 3 doi: 10.1002/ajh.24947. PMID: 29047158

Prognosis

Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Whitlock JA, Malvar J, Dalla-Pozza L, Goldberg JM, Silverman LB, Ziegler DS, Attarbaschi A, Brown PA, Gardner RA, Gaynon PS, Hutchinson R, Huynh VT, Jeha S, Marcus L, Messinger Y, Schultz KR, Cassar J, Locatelli F, Zwaan CM, Wood BL, Sposto R, Gore L
Pediatr Blood Cancer 2022 Nov;69(11):e29901. Epub 2022 Aug 21 doi: 10.1002/pbc.29901. PMID: 35989458
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Teachey DT, O'Connor D
Blood 2020 Jan 16;135(3):159-166. doi: 10.1182/blood.2019001557. PMID: 31738819Free PMC Article
You MJ, Medeiros LJ, Hsi ED
Am J Clin Pathol 2015 Sep;144(3):411-22. doi: 10.1309/AJCPMF03LVSBLHPJ. PMID: 26276771

Clinical prediction guides

Xu X, Paxton CN, Hayashi RJ, Dunsmore KP, Winter SS, Hunger SP, Winick NJ, Carroll WL, Loh ML, Devidas M, Gross TG, Bollard CM, Perkins SL, Miles RR
Blood Adv 2021 Jul 27;5(14):2890-2900. doi: 10.1182/bloodadvances.2021004334. PMID: 34297047Free PMC Article
Sengar M, Carr R, Jain H, Chanana R, Rangarajan V, Sridhar E, Shet T, Menon H, Gujral S, Laskar S
Indian J Cancer 2020 Jul-Sep;57(3):262-266. doi: 10.4103/ijc.IJC_616_18. PMID: 32594075
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Guan W, Jing Y, Dou L, Wang M, Xiao Y, Yu L
Leuk Lymphoma 2020 Apr;61(4):855-861. Epub 2019 Nov 22 doi: 10.1080/10428194.2019.1691195. PMID: 31755348
Horton TM, Whitlock JA, Lu X, O'Brien MM, Borowitz MJ, Devidas M, Raetz EA, Brown PA, Carroll WL, Hunger SP
Br J Haematol 2019 Jul;186(2):274-285. Epub 2019 Apr 7 doi: 10.1111/bjh.15919. PMID: 30957229Free PMC Article

Recent systematic reviews

Saglam A, Singh K, Gollapudi S, Kumar J, Brar N, Butzmann A, Warnke R, Ohgami RS
Int J Lab Hematol 2022 Aug;44(4):700-711. Epub 2022 May 16 doi: 10.1111/ijlh.13873. PMID: 35577551

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