U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Base-Base Mismatch

MedGen UID:
267029
•Concept ID:
C1511065
•
Cell or Molecular Dysfunction

Definition

Base-Base Mismatch results from mutagenic factors that induce chemical modification of DNA bases so that pairing between specific bases on complementary DNA strands is eliminated causing mispairing. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBase-Base Mismatch

Professional guidelines

PubMed

Biomarker-guided implementation of the old drug temozolomide as a novel treatment option for patients with metastatic colorectal cancer.
Pietrantonio F, Randon G, Romagnoli D, Di Donato S, Benelli M, de Braud F
Cancer Treat Rev 2020 Jan;82:101935. Epub 2019 Nov 28 doi: 10.1016/j.ctrv.2019.101935. PMID: 31821983
Dual-Channel Surface Plasmon Resonance for Quantification of ApoE Gene and Genotype Discrimination in Unamplified Genomic DNA Extracts.
Yi X, Xia Y, Ding B, Wu L, Hu S, Wang Z, Yang M, Wang J
ACS Sens 2018 Nov 26;3(11):2402-2407. Epub 2018 Oct 26 doi: 10.1021/acssensors.8b00845. PMID: 30350593
CYP3A5 phenotype-genotype correlations in a British population.
King BP, Leathart JB, Mutch E, Williams FM, Daly AK
Br J Clin Pharmacol 2003 Jun;55(6):625-9. doi: 10.1046/j.1365-2125.2003.01798.x. PMID: 12814460Free PMC Article

Recent clinical studies

Diagnosis

Effects of DNA polymerase kappa and mismatch repair on dose-responses of chromosome aberrations induced by three oxidative genotoxins in human cells.
Nohmi T, Matsumoto K
Environ Mol Mutagen 2020 Jan;61(1):193-199. Epub 2019 Jul 25 doi: 10.1002/em.22315. PMID: 31294882
Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, Wheeler VC
PLoS Genet 2013 Oct;9(10):e1003930. Epub 2013 Oct 31 doi: 10.1371/journal.pgen.1003930. PMID: 24204323Free PMC Article
hMSH3 overexpression and cellular response to cytotoxic anticancer agents.
Pepponi R, Graziani G, Falcinelli S, Vernole P, Levati L, Lacal PM, Pagani E, Bonmassar E, Jiricny J, D'Atri S
Carcinogenesis 2001 Aug;22(8):1131-7. doi: 10.1093/carcin/22.8.1131. PMID: 11470740

Clinical prediction guides

Effects of DNA polymerase kappa and mismatch repair on dose-responses of chromosome aberrations induced by three oxidative genotoxins in human cells.
Nohmi T, Matsumoto K
Environ Mol Mutagen 2020 Jan;61(1):193-199. Epub 2019 Jul 25 doi: 10.1002/em.22315. PMID: 31294882
Interaction of nick-directed DNA mismatch repair and loop repair in human cells.
Huang YM, Chen SU, Goodman SD, Wu SH, Kao JT, Lee CN, Cheng WC, Tsai KS, Fang WH
J Biol Chem 2004 Jul 16;279(29):30228-35. Epub 2004 May 18 doi: 10.1074/jbc.M401675200. PMID: 15151992

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...