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del(13q14)

MedGen UID:
271837
•Concept ID:
C1515582
•
Cell or Molecular Dysfunction
Synonym: del(13)(q14)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(13q14)

Professional guidelines

PubMed

Microfluidic enrichment of plasma cells improves treatment of multiple myeloma.
Zeng Y, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC, Zhang X, Zhong JF
Mol Oncol 2018 Jun;12(7):1004-1011. Epub 2018 May 12 doi: 10.1002/1878-0261.12201. PMID: 29638042Free PMC Article
Outcome of allogeneic transplantation in newly diagnosed and relapsed/refractory multiple myeloma: long-term follow-up in a single institution.
Franssen LE, Raymakers RA, Buijs A, Schmitz MF, van Dorp S, Mutis T, Lokhorst HM, van de Donk NW
Eur J Haematol 2016 Nov;97(5):479-488. Epub 2016 May 3 doi: 10.1111/ejh.12758. PMID: 27028304

Recent clinical studies

Etiology

Plasmablastic myeloma in Taiwan frequently presents with extramedullary and extranodal mass mimicking plasmablastic lymphoma.
Chen BJ, Yuan CT, Yang CF, Ho CH, Lin YK, Su YZ, Chou HC, Chuang SS
Virchows Arch 2022 Aug;481(2):283-293. Epub 2022 Jun 3 doi: 10.1007/s00428-022-03342-3. PMID: 35657404
Chronic lymphocytic leukemia in a young population.
Alshemmari SH, Hamdah A, Pandita R, Kunhikrishnan A
Leuk Res 2021 Nov;110:106668. Epub 2021 Jul 15 doi: 10.1016/j.leukres.2021.106668. PMID: 34492597
Role of cytogenetic abnormalities detected by fluorescence in situ hybridization as a prognostic marker: Pathogenesis & clinical course in patients with B-chronic lymphocytic leukaemia.
Shetty D, Jain H, Rohil Y, Khattry N, Sengar M, Bagal B, Jain H, Gokarn A, Punatar S, Avinash Bonda VN, Subramanian PG
Indian J Med Res 2021 Apr;153(4):475-483. doi: 10.4103/ijmr.IJMR_2257_18. PMID: 34380794Free PMC Article
Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.
Bogusz AM, Bagg A
Leuk Lymphoma 2016 Sep;57(9):1991-2013. Epub 2016 Apr 27 doi: 10.3109/10428194.2016.1173212. PMID: 27121112
Intermediate prognosis of 6q deletion in chronic lymphocytic leukemia.
Wang DM, Miao KR, Fan L, Qiu HR, Fang C, Zhu DX, Qiu HX, Xu W, Li JY
Leuk Lymphoma 2011 Feb;52(2):230-7. doi: 10.3109/10428194.2010.542599. PMID: 21281237

Diagnosis

Plasmablastic myeloma in Taiwan frequently presents with extramedullary and extranodal mass mimicking plasmablastic lymphoma.
Chen BJ, Yuan CT, Yang CF, Ho CH, Lin YK, Su YZ, Chou HC, Chuang SS
Virchows Arch 2022 Aug;481(2):283-293. Epub 2022 Jun 3 doi: 10.1007/s00428-022-03342-3. PMID: 35657404
Chronic lymphocytic leukemia in a young population.
Alshemmari SH, Hamdah A, Pandita R, Kunhikrishnan A
Leuk Res 2021 Nov;110:106668. Epub 2021 Jul 15 doi: 10.1016/j.leukres.2021.106668. PMID: 34492597
Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.
Bogusz AM, Bagg A
Leuk Lymphoma 2016 Sep;57(9):1991-2013. Epub 2016 Apr 27 doi: 10.3109/10428194.2016.1173212. PMID: 27121112
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Intermediate prognosis of 6q deletion in chronic lymphocytic leukemia.
Wang DM, Miao KR, Fan L, Qiu HR, Fang C, Zhu DX, Qiu HX, Xu W, Li JY
Leuk Lymphoma 2011 Feb;52(2):230-7. doi: 10.3109/10428194.2010.542599. PMID: 21281237

Therapy

Bortezomib-based regimens improve the prognosis of newly diagnosed MM patients with chromosomal aberrations except for del(17q13): A retrospective study from a single center.
Liu Z, Zeng Q, Xiang B
Medicine (Baltimore) 2021 May 7;100(18):e25834. doi: 10.1097/MD.0000000000025834. PMID: 33950994Free PMC Article
Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China.
Wang H, Meng H, Wang J, Lou Y, Zhou Y, Lin P, Li F, Liu L, Xu H, Yang M, Jin J
Front Med 2020 Jun;14(3):327-334. Epub 2019 Nov 29 doi: 10.1007/s11684-019-0712-x. PMID: 31784918
Microfluidic enrichment of plasma cells improves treatment of multiple myeloma.
Zeng Y, Gao L, Luo X, Chen Y, Kabeer MH, Chen X, Stucky A, Loudon WG, Li SC, Zhang X, Zhong JF
Mol Oncol 2018 Jun;12(7):1004-1011. Epub 2018 May 12 doi: 10.1002/1878-0261.12201. PMID: 29638042Free PMC Article
Additional genetic abnormalities significantly worsen poor prognosis associated with 1q21 amplification in multiple myeloma patients.
Grzasko N, Hus M, Pluta A, Jurczyszyn A, Walter-Croneck A, Morawska M, Chocholska S, Hajek R, Dmoszynska A
Hematol Oncol 2013 Mar;31(1):41-8. Epub 2012 Jun 6 doi: 10.1002/hon.2018. PMID: 22674819
Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone.
Klein U, Jauch A, Hielscher T, Hillengass J, Raab MS, Seckinger A, Hose D, Ho AD, Goldschmidt H, Neben K
Cancer 2011 May 15;117(10):2136-44. Epub 2010 Dec 4 doi: 10.1002/cncr.25775. PMID: 21523726

Prognosis

Plasmablastic myeloma in Taiwan frequently presents with extramedullary and extranodal mass mimicking plasmablastic lymphoma.
Chen BJ, Yuan CT, Yang CF, Ho CH, Lin YK, Su YZ, Chou HC, Chuang SS
Virchows Arch 2022 Aug;481(2):283-293. Epub 2022 Jun 3 doi: 10.1007/s00428-022-03342-3. PMID: 35657404
Chronic lymphocytic leukemia in a young population.
Alshemmari SH, Hamdah A, Pandita R, Kunhikrishnan A
Leuk Res 2021 Nov;110:106668. Epub 2021 Jul 15 doi: 10.1016/j.leukres.2021.106668. PMID: 34492597
Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets.
Bogusz AM, Bagg A
Leuk Lymphoma 2016 Sep;57(9):1991-2013. Epub 2016 Apr 27 doi: 10.3109/10428194.2016.1173212. PMID: 27121112
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Genetics of small lymphocyte disorders.
Panayiotidis P, Kotsi P
Semin Hematol 1999 Apr;36(2):171-7. PMID: 10319386

Clinical prediction guides

Prevalence of cytogenetic abnormalities in chronic lymphocytic leukemia in the southern part of Turkey.
Bagir EK, Acikalin A, Alsancak P, Paydas S, Gurkan E, Ergin M
Indian J Cancer 2017 Jul-Sep;54(3):572-575. doi: 10.4103/ijc.IJC_291_17. PMID: 29798961
Bcl-2 level as a biomarker for 13q14 deletion in CLL.
Degheidy HA, Gadalla SM, Farooqui MZ, Abbasi F, Arthur DC, Bauer SR, Wilson WH, Wiestner A, Stetler-Stevenson MA, Marti GE
Cytometry B Clin Cytom 2013 Jul-Aug;84(4):237-47. Epub 2013 May 14 doi: 10.1002/cyto.b.21090. PMID: 23674504Free PMC Article
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Clinical and molecular characterization of diffuse large B-cell lymphomas with 13q14.3 deletion.
Mian M, Scandurra M, Chigrinova E, Shen Y, Inghirami G, Greiner TC, Chan WC, Vose JM, Testoni M, Chiappella A, Baldini L, Ponzoni M, Ferreri AJM, Franceschetti S, Gaidano G, Montes-Moreno S, Piris MA, Facchetti F, Tucci A, Nomdedeu JF, Lazure T, Uccella S, Tibiletti MG, Zucca E, Kwee I, Bertoni F
Ann Oncol 2012 Mar;23(3):729-735. Epub 2011 Jun 21 doi: 10.1093/annonc/mdr289. PMID: 21693768
Genetics of small lymphocyte disorders.
Panayiotidis P, Kotsi P
Semin Hematol 1999 Apr;36(2):171-7. PMID: 10319386

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