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Metastasizing Pleomorphic Adenoma of the Salivary Gland

MedGen UID:: 277361
•Concept ID:: C1334711
•: Neoplastic Process

Synonyms:

Metastasizing Mixed Tumor of Salivary Gland; Metastasizing Mixed Tumor of the Salivary Gland

Definition

A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features. The most common sites of metastasis are bone, lung, and head and neck. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastasizing Pleomorphic Adenoma of the Salivary Gland

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Metastatic Benign Neoplasm
        Metastasizing Pleomorphic Adenoma of the Salivary Gland

Professional guidelines

PubMed

Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.

Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169 Free PMC Article

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669 Free PMC Article

Vinorelbine treatment of recurrent salivary gland carcinomas.

Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

See all (10)

Recent clinical studies

Etiology

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.

Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740 Free PMC Article

Clinicopathological analysis and survival outcomes of primary salivary gland tumors in pediatric patients: A systematic review.

Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344

Parapharyngeal space primary tumours.

Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220

Metastasizing pleomorphic adenoma of the salivary gland.

Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Imaging of salivary gland tumours.

Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041

See all (99)

Diagnosis

Myoepithelial Carcinoma.

Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224 Free PMC Article

Maxillofacial diagnostic features of the enigmatic metastasizing pleomorphic adenoma.

Shoukair FL, Maly A, Haran TK, Hirshoren N, Abu Tair J
Int J Oral Maxillofac Surg 2020 Jul;49(7):841-847. Epub 2020 Jan 28 doi: 10.1016/j.ijom.2020.01.002. PMID: 32005572

Parapharyngeal space primary tumours.

Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220

Metastasizing pleomorphic adenoma of the salivary gland.

Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Tracheobronchial gland tumors.

Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

See all (140)

Therapy

Parotid salivary duct carcinoma: a single institution's 20-year experience.

Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093 Free PMC Article

Small cell carcinoma ex-pleomorphic adenoma of the parotid gland.

Cimino-Mathews A, Lin BM, Chang SS, Boahene KD, Bishop JA
Head Neck Pathol 2012 Dec;6(4):502-6. Epub 2012 Jun 27 doi: 10.1007/s12105-012-0376-1. PMID: 22736150 Free PMC Article

Tracheobronchial gland tumors.

Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

First insights into the molecular basis of pleomorphic adenomas of the salivary glands.

Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Chemotherapy for salivary gland cancer.

Kaplan MJ, Johns ME, Cantrell RW
Otolaryngol Head Neck Surg 1986 Sep;95(2):165-70. doi: 10.1177/019459988609500206. PMID: 3035459

See all (15)

Prognosis

Parotid incidentalomas: a systematic review.

Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.

Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740 Free PMC Article

Myoepithelial Carcinoma.

Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224 Free PMC Article

Metastasising pleomorphic adenoma: Systematic review.

Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

Metastasizing pleomorphic adenoma of the salivary gland.

Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

See all (131)

Clinical prediction guides

Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.

Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740 Free PMC Article

High levels of ANXA2 are characteristic of malignant salivary gland tumors.

Cardoso CM, de Jesus SF, de Souza MG, Queiroz LDRP, Santos EM, Dos Santos EP, Oliveira LP, Cordeiro Santos CK, Santos SHS, de Paula AMB, Farias LC, Guimaraes ALS
J Oral Pathol Med 2019 Nov;48(10):929-934. Epub 2019 Aug 5 doi: 10.1111/jop.12932. PMID: 31325182

Histologic grading and prognostic biomarkers in salivary gland carcinomas.

Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736

Metastasizing pleomorphic adenoma of the salivary gland.

Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Metastasizing pleomorphic salivary adenoma.

Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191

See all (57)