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Gastric diffuse large B-cell lymphoma

MedGen UID:
277530
•Concept ID:
C1335483
•
Neoplastic Process
Synonyms: Gastric Diffuse Large B-Cell Lymphoma; gastric diffuse large B-cell lymphoma; Primary Diffuse Large B-Cell Gastric Lymphoma; primary diffuse large B-cell gastric lymphoma; Primary Diffuse Large B-Cell Lymphoma of Stomach; primary diffuse large B-cell lymphoma of stomach; Primary Diffuse Large B-Cell Lymphoma of the Stomach; primary diffuse large B-cell lymphoma of the stomach; Primary Gastric Diffuse Large B-Cell Lymphoma; primary gastric diffuse large B-cell lymphoma
 
Monarch Initiative: MONDO:0006223

Definition

An extranodal diffuse large B-cell lymphoma that arises from the stomach with the bulk of the mass located in the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric diffuse large B-cell lymphoma

Professional guidelines

PubMed

A study on the prevention of hemorrhage and perforation in patients with primary gastric diffuse large-B cell lymphoma during treatment with immunochemotherapy.
Zhang L, Huang H, Wang Z, Fang X, Hong H, Chen Y, Ren Q, Yao Y, Chen Z, Pan F, Li X, Chen M, Lin T
Cancer Med 2023 Mar;12(6):6924-6934. Epub 2023 Jan 9 doi: 10.1002/cam4.5486. PMID: 36621835Free PMC Article
A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors.
Bai Z, Zhou Y
Leuk Res 2021 Dec;111:106716. Epub 2021 Oct 1 doi: 10.1016/j.leukres.2021.106716. PMID: 34627052
Rituximab in treatment of primary gastric diffuse large B-cell lymphoma.
Zhang J, Li G, Yang H, Liu X, Cao J
Leuk Lymphoma 2012 Nov;53(11):2175-81. Epub 2012 Apr 19 doi: 10.3109/10428194.2012.680451. PMID: 22462613

Recent clinical studies

Etiology

Outcome and patterns of relapse in primary gastric diffuse large B cell lymphoma treated with RCHOP.
Ma'koseh M, Farfoura H, Abufara A, Elmusa R, Hushki A, Faqeer N, Ghatasheh H, Shahin O, Alawabdeh T, Al-Rwashdeh M, Halahleh K, Al-Ibraheem A, Alrabi K
Hematology 2023 Dec;28(1):2198898. doi: 10.1080/16078454.2023.2198898. PMID: 37114663
miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Gastrointestinal lymphoma.
Bierman PJ
Curr Treat Options Oncol 2003 Oct;4(5):421-30. doi: 10.1007/s11864-003-0043-6. PMID: 12941202

Diagnosis

miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors.
Bai Z, Zhou Y
Leuk Res 2021 Dec;111:106716. Epub 2021 Oct 1 doi: 10.1016/j.leukres.2021.106716. PMID: 34627052
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article

Therapy

Outcome and patterns of relapse in primary gastric diffuse large B cell lymphoma treated with RCHOP.
Ma'koseh M, Farfoura H, Abufara A, Elmusa R, Hushki A, Faqeer N, Ghatasheh H, Shahin O, Alawabdeh T, Al-Rwashdeh M, Halahleh K, Al-Ibraheem A, Alrabi K
Hematology 2023 Dec;28(1):2198898. doi: 10.1080/16078454.2023.2198898. PMID: 37114663
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article
De-escalating therapy in gastric aggressive lymphoma.
Cuccurullo R, Govi S, Ferreri AJ
World J Gastroenterol 2014 Jul 21;20(27):8993-7. doi: 10.3748/wjg.v20.i27.8993. PMID: 25083073Free PMC Article

Prognosis

Outcome and patterns of relapse in primary gastric diffuse large B cell lymphoma treated with RCHOP.
Ma'koseh M, Farfoura H, Abufara A, Elmusa R, Hushki A, Faqeer N, Ghatasheh H, Shahin O, Alawabdeh T, Al-Rwashdeh M, Halahleh K, Al-Ibraheem A, Alrabi K
Hematology 2023 Dec;28(1):2198898. doi: 10.1080/16078454.2023.2198898. PMID: 37114663
miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors.
Bai Z, Zhou Y
Leuk Res 2021 Dec;111:106716. Epub 2021 Oct 1 doi: 10.1016/j.leukres.2021.106716. PMID: 34627052
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804

Clinical prediction guides

Evaluation of clinical and prognostic factors for primary gastric diffuse large B-cell lymphoma: Single-center experience.
Bardakci M, Esmer DD, Hafizoglu E, Karaman K, Kuzu OF, Karakas H, Gungorer B, Uncu D
J Cancer Res Ther 2023 Apr-Jun;19(3):778-782. doi: 10.4103/jcrt.jcrt_2111_21. PMID: 37470610
Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma.
Zeng H, Wang J, Xu B, Deng H, Peng M, Deng R, Shang S, Hu Q, Li J, Lin J, Zhu H, Li Y, Zuo C
Oncol Rep 2023 May;49(5) Epub 2023 Mar 17 doi: 10.3892/or.2023.8525. PMID: 36928140Free PMC Article
miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article

Recent systematic reviews

A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors.
Bai Z, Zhou Y
Leuk Res 2021 Dec;111:106716. Epub 2021 Oct 1 doi: 10.1016/j.leukres.2021.106716. PMID: 34627052

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