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Urethral Undifferentiated Carcinoma

MedGen UID:
277842
Concept ID:
C1336867
Neoplastic Process
Synonyms: Anaplastic Carcinoma of the Urethra; Anaplastic Carcinoma of Urethra; Anaplastic Urethra Carcinoma; Anaplastic Urethral Carcinoma; Undifferentiated Carcinoma of the Urethra; Undifferentiated Carcinoma of Urethra; Undifferentiated Urethra Carcinoma; Undifferentiated Urethral Carcinoma

Definition

An undifferentiated carcinoma arising from the urethra. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrethral Undifferentiated Carcinoma

Professional guidelines

PubMed

Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513
Chan Y, Fisher P, Tilki D, Evans CP
BJU Int 2016 Apr;117(4):563-9. Epub 2015 Dec 12 doi: 10.1111/bju.13370. PMID: 26556525
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Recent clinical studies

Etiology

Dell'Atti L, Galosi AB
Clin Genitourin Cancer 2018 Apr;16(2):e263-e267. Epub 2017 Oct 16 doi: 10.1016/j.clgc.2017.10.006. PMID: 29113768
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Berjeaut RH, Persaud MD, Sopko N, Burnett AL
Int Urol Nephrol 2017 Apr;49(4):637-641. Epub 2017 Jan 18 doi: 10.1007/s11255-017-1512-3. PMID: 28101735
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Walsh DL, Chang SS
Urol Oncol 2009 Jul-Aug;27(4):352-7. Epub 2008 Apr 24 doi: 10.1016/j.urolonc.2007.12.010. PMID: 18439852

Diagnosis

Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Dell'Atti L, Galosi AB
Clin Genitourin Cancer 2018 Apr;16(2):e263-e267. Epub 2017 Oct 16 doi: 10.1016/j.clgc.2017.10.006. PMID: 29113768
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Ragonese M, Racioppi M, D'Agostino D, Di Gianfrancesco L, Lenci N, Bientinesi R, Palermo G, Sacco E, Pinto F, Bassi PF
Urologia 2016 May 24;83(2):55-60. Epub 2016 Mar 14 doi: 10.5301/uro.5000131. PMID: 26481721
Ahmed K, Dasgupta R, Vats A, Nagpal K, Ashrafian H, Kaj B, Athanasiou T, Dasgupta P, Khan MS
Int Urol Nephrol 2010 Jun;42(2):331-41. Epub 2009 Aug 2 doi: 10.1007/s11255-009-9618-x. PMID: 19649767

Therapy

Boorjian SA, Alemozaffar M, Konety BR, Shore ND, Gomella LG, Kamat AM, Bivalacqua TJ, Montgomery JS, Lerner SP, Busby JE, Poch M, Crispen PL, Steinberg GD, Schuckman AK, Downs TM, Svatek RS, Mashni J Jr, Lane BR, Guzzo TJ, Bratslavsky G, Karsh LI, Woods ME, Brown G, Canter D, Luchey A, Lotan Y, Krupski T, Inman BA, Williams MB, Cookson MS, Keegan KA, Andriole GL Jr, Sankin AI, Boyd A, O'Donnell MA, Sawutz D, Philipson R, Coll R, Narayan VM, Treasure FP, Yla-Herttuala S, Parker NR, Dinney CPN
Lancet Oncol 2021 Jan;22(1):107-117. Epub 2020 Nov 27 doi: 10.1016/S1470-2045(20)30540-4. PMID: 33253641Free PMC Article
Parker CC, Clarke NW, Cook AD, Kynaston HG, Petersen PM, Catton C, Cross W, Logue J, Parulekar W, Payne H, Persad R, Pickering H, Saad F, Anderson J, Bahl A, Bottomley D, Brasso K, Chahal R, Cooke PW, Eddy B, Gibbs S, Goh C, Gujral S, Heath C, Henderson A, Jaganathan R, Jakobsen H, James ND, Kanaga Sundaram S, Lees K, Lester J, Lindberg H, Money-Kyrle J, Morris S, O'Sullivan J, Ostler P, Owen L, Patel P, Pope A, Popert R, Raman R, Røder MA, Sayers I, Simms M, Wilson J, Zarkar A, Parmar MKB, Sydes MR
Lancet 2020 Oct 31;396(10260):1413-1421. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31553-1. PMID: 33002429
Whiteside SA, Razvi H, Dave S, Reid G, Burton JP
Nat Rev Urol 2015 Feb;12(2):81-90. Epub 2015 Jan 20 doi: 10.1038/nrurol.2014.361. PMID: 25600098
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Trabulsi EJ, Hoffman-Censits J
Urol Clin North Am 2010 Aug;37(3):467-74. doi: 10.1016/j.ucl.2010.04.010. PMID: 20674701

Prognosis

Tan Q, Le H, Tang C, Zhang M, Yang W, Hong Y, Wang X
J Nanobiotechnology 2022 Aug 31;20(1):392. doi: 10.1186/s12951-022-01599-z. PMID: 36045428Free PMC Article
Dell'Atti L, Galosi AB
Clin Genitourin Cancer 2018 Apr;16(2):e263-e267. Epub 2017 Oct 16 doi: 10.1016/j.clgc.2017.10.006. PMID: 29113768
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439
Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM; European Association of Urology
Eur Urol 2013 Nov;64(5):823-30. Epub 2013 Apr 2 doi: 10.1016/j.eururo.2013.03.044. PMID: 23582479
Lamm DL
Urol Clin North Am 1992 Aug;19(3):499-508. PMID: 1636234

Clinical prediction guides

Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebianco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, van der Heijden AG
Eur Urol 2024 Jan;85(1):17-31. Epub 2023 Oct 17 doi: 10.1016/j.eururo.2023.08.016. PMID: 37858453
Serrell EC, McAchran SE
Obstet Gynecol Clin North Am 2021 Sep;48(3):599-616. doi: 10.1016/j.ogc.2021.05.011. PMID: 34416940
Parker CC, Clarke NW, Cook AD, Kynaston HG, Petersen PM, Catton C, Cross W, Logue J, Parulekar W, Payne H, Persad R, Pickering H, Saad F, Anderson J, Bahl A, Bottomley D, Brasso K, Chahal R, Cooke PW, Eddy B, Gibbs S, Goh C, Gujral S, Heath C, Henderson A, Jaganathan R, Jakobsen H, James ND, Kanaga Sundaram S, Lees K, Lester J, Lindberg H, Money-Kyrle J, Morris S, O'Sullivan J, Ostler P, Owen L, Patel P, Pope A, Popert R, Raman R, Røder MA, Sayers I, Simms M, Wilson J, Zarkar A, Parmar MKB, Sydes MR
Lancet 2020 Oct 31;396(10260):1413-1421. Epub 2020 Sep 28 doi: 10.1016/S0140-6736(20)31553-1. PMID: 33002429
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Whiteside SA, Razvi H, Dave S, Reid G, Burton JP
Nat Rev Urol 2015 Feb;12(2):81-90. Epub 2015 Jan 20 doi: 10.1038/nrurol.2014.361. PMID: 25600098

Recent systematic reviews

Guo J, Liang X, Zheng Y, Ma J
J Cancer Res Clin Oncol 2023 Jun;149(6):2693-2698. Epub 2022 Nov 21 doi: 10.1007/s00432-022-04481-5. PMID: 36414814
Laukhtina E, Moschini M, Soria F, Andrea DD, Teoh JY, Mori K, Albisinni S, Mari A, Krajewski W, Cimadamore A, Abufaraj M, Enikeev D, Neuzillet Y, Giannarini G, Xylinas E, Kamat AM, Roupret M, Babjuk M, Witjes JA, Shariat SF, Pradere B; European Association of Urology; Young Academic Urologists EAU-YAU: Urothelial Carcinoma Working Group; European Association of Urology Section of Oncological Urology ESOU
Eur Urol Focus 2022 Nov;8(6):1635-1642. Epub 2022 Mar 23 doi: 10.1016/j.euf.2022.03.004. PMID: 35337773
Carando R, Shariat SF, Moschini M, D'Andrea D
Curr Opin Urol 2020 May;30(3):441-448. doi: 10.1097/MOU.0000000000000752. PMID: 32235282
Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Kübler H, Stenzl A, Gakis G
Urol Oncol 2018 Feb;36(2):54-59. Epub 2017 Nov 28 doi: 10.1016/j.urolonc.2017.11.007. PMID: 29196179
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article

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