U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Phototoxicity

MedGen UID:
282896
•Concept ID:
C1527358
•
Disease or Syndrome
SNOMED CT: Phototoxicity (84326006)

Definition

A nonimmunologic, chemically induced type of photosensitivity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhototoxicity

Professional guidelines

PubMed

Targeting the central melanocortin system for the treatment of metabolic disorders.
Sweeney P, Gimenez LE, Hernandez CC, Cone RD
Nat Rev Endocrinol 2023 Sep;19(9):507-519. Epub 2023 Jun 26 doi: 10.1038/s41574-023-00855-y. PMID: 37365323
Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang B, Balwani M; Porphyrias Consortium of the Rare Diseases Clinical Research Network
J Am Acad Dermatol 2023 Dec;89(6):1227-1237. Epub 2022 Aug 27 doi: 10.1016/j.jaad.2022.08.036. PMID: 36041558Free PMC Article
Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.
Balwani M
Mol Genet Metab 2019 Nov;128(3):298-303. Epub 2019 Jan 24 doi: 10.1016/j.ymgme.2019.01.020. PMID: 30704898Free PMC Article

Recent clinical studies

Etiology

Tetracyclines-An Important Therapeutic Tool for Dermatologists.
Orylska-Ratynska M, Placek W, Owczarczyk-Saczonek A
Int J Environ Res Public Health 2022 Jun 13;19(12) doi: 10.3390/ijerph19127246. PMID: 35742496Free PMC Article
Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
RIFM low-exposure fragrance ingredients safety assessment.
Api AM, Belsito D, Biserta S, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Gadhia S, Jones L, Joshi K, Lapczynski A, Lavelle M, Liebler DC, Na M, O'Brien D, Patel A, Penning TM, Ritacco G, Rodriguez-Ropero F, Romine J, Sadekar N, Salvito D, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S
Food Chem Toxicol 2021 Mar;149 Suppl 1:111981. Epub 2021 Feb 10 doi: 10.1016/j.fct.2021.111981. PMID: 33577945
Retinal injury from handheld lasers: a review.
Bhavsar KV, Michel Z, Greenwald M, Cunningham ET Jr,, Freund KB
Surv Ophthalmol 2021 Mar-Apr;66(2):231-260. Epub 2020 Jul 3 doi: 10.1016/j.survophthal.2020.06.006. PMID: 32628946
Mechanisms of blue light-induced eye hazard and protective measures: a review.
Ouyang X, Yang J, Hong Z, Wu Y, Xie Y, Wang G
Biomed Pharmacother 2020 Oct;130:110577. Epub 2020 Aug 4 doi: 10.1016/j.biopha.2020.110577. PMID: 32763817

Diagnosis

Anticancer treatments and photosensitivity.
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Feeling the Burn: Phototoxicity and Photoallergy.
Hinton AN, Goldminz AM
Dermatol Clin 2020 Jan;38(1):165-175. doi: 10.1016/j.det.2019.08.010. PMID: 31753189
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670
Drug-induced photosensitivity.
Dawe RS, Ibbotson SH
Dermatol Clin 2014 Jul;32(3):363-8, ix. doi: 10.1016/j.det.2014.03.014. PMID: 24891058

Therapy

Dersimelagon in Erythropoietic Protoporphyrias.
Balwani M, Bonkovsky HL, Levy C, Anderson KE, Bissell DM, Parker C, Takahashi F, Desnick RJ, Belongie K; Endeavor Investigators
N Engl J Med 2023 Apr 13;388(15):1376-1385. doi: 10.1056/NEJMoa2208754. PMID: 37043653
Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
Photosensitizing drug reactions.
Montgomery S, Worswick S
Clin Dermatol 2022 Jan-Feb;40(1):57-63. Epub 2021 Aug 8 doi: 10.1016/j.clindermatol.2021.08.014. PMID: 35190066
Mechanisms of blue light-induced eye hazard and protective measures: a review.
Ouyang X, Yang J, Hong Z, Wu Y, Xie Y, Wang G
Biomed Pharmacother 2020 Oct;130:110577. Epub 2020 Aug 4 doi: 10.1016/j.biopha.2020.110577. PMID: 32763817
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670

Prognosis

Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
Molecular mechanisms of drug photodegradation and photosensitization.
Zaheer MR, Gupta A, Iqbal J, Zia Q, Ahmad A, Roohi, Owais M, Hashlamon A, Mohd Setapar SH, Ashraf GM, Aliev G
Curr Pharm Des 2016;22(7):768-82. doi: 10.2174/1381612822666151209151408. PMID: 26675230
Drug-induced photosensitivity.
Dawe RS, Ibbotson SH
Dermatol Clin 2014 Jul;32(3):363-8, ix. doi: 10.1016/j.det.2014.03.014. PMID: 24891058
Phototoxicity and photocarcinogenesis associated with voriconazole.
Epaulard O, Leccia MT, Blanche S, Chosidow O, Mamzer-Bruneel MF, Ravaud P, Thiebaut A, Villier C, Lortholary O
Med Mal Infect 2011 Dec;41(12):639-45. Epub 2011 Nov 3 doi: 10.1016/j.medmal.2011.09.016. PMID: 22055586
Macular microholes.
Emerson GG, Spencer GR, Klein ML
Retina 2007 Jun;27(5):595-600. doi: 10.1097/01.iae.0000243068.68099.b4. PMID: 17558322

Clinical prediction guides

Anticancer treatments and photosensitivity.
Sibaud V
J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6(Suppl 6):51-58. doi: 10.1111/jdv.18200. PMID: 35738806Free PMC Article
Outer Foveal Microdefects.
Cohen SY, Mrejen S, Nghiem-Buffet S, Dubois L, Fajnkuchen F, Gaudric A
Ophthalmol Retina 2021 Jun;5(6):553-561. Epub 2020 Sep 30 doi: 10.1016/j.oret.2020.09.018. PMID: 33007522
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670
Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y
J Dermatol Sci 2017 Jan;85(1):4-11. Epub 2016 Aug 6 doi: 10.1016/j.jdermsci.2016.08.005. PMID: 27528585
Tracking cancer drugs in living cells by thermal profiling of the proteome.
Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G
Science 2014 Oct 3;346(6205):1255784. Epub 2014 Oct 2 doi: 10.1126/science.1255784. PMID: 25278616

Recent systematic reviews

Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.
Negi S, Bala L, Shukla S, Chopra D
Toxicol Ind Health 2022 Jul;38(7):417-434. Epub 2022 May 19 doi: 10.1177/07482337221100870. PMID: 35592919
Blue light filtering ophthalmic lenses: A systematic review.
Vagge A, Ferro Desideri L, Del Noce C, Di Mola I, Sindaco D, Traverso CE
Semin Ophthalmol 2021 Oct 3;36(7):541-548. Epub 2021 Mar 18 doi: 10.1080/08820538.2021.1900283. PMID: 33734926
Drug-induced phototoxicity: A systematic review.
Kim WB, Shelley AJ, Novice K, Joo J, Lim HW, Glassman SJ
J Am Acad Dermatol 2018 Dec;79(6):1069-1075. Epub 2018 Jul 10 doi: 10.1016/j.jaad.2018.06.061. PMID: 30003982
The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: a systematic review of the literature.
Lawrenson JG, Hull CC, Downie LE
Ophthalmic Physiol Opt 2017 Nov;37(6):644-654. doi: 10.1111/opo.12406. PMID: 29044670
Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles.
Sousa J, Alves G, Fortuna A, Falcão A
Curr Drug Saf 2014;9(2):89-105. doi: 10.2174/1574886308666140106154754. PMID: 24410307

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...