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Eosinophilic pneumonia

MedGen UID:: 282904
•Concept ID:: C1527407
•: Disease or Syndrome

Synonyms:	Loeffler syndrome; Pulmonary infiltrates with eosinophilia
SNOMED CT:	EP - Eosinophilic pneumonia (367542003); Eosinophilic pneumonia (367542003)

HPO:	HP:0032071
Monarch Initiative:	MONDO:0005749

Definition

The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVEosinophilic pneumonia

Phenotypic abnormality
- Abnormality of the respiratory system
  - Abnormal respiratory system physiology
    - Abnormal respiratory system morphology
      - Abnormality of the lung
        Abnormal pulmonary interstitial morphology
        Eosinophilic pneumonia
        Chronic eosinophilic pneumonia
        Simple pulmonary eosinophilia

Professional guidelines

PubMed

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.

Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537

Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.

De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

See all (22)

Recent clinical studies

Etiology

Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089

Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Smoking-associated interstitial lung disease: update and review.

Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511

Eosinophilic Pneumonias.

Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405

See all (199)

Diagnosis

Eosinophilic Lung Diseases.

Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.

Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537

Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.

De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Eosinophilic Lung Diseases.

Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599

See all (506)

Therapy

Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089

Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166

Immunomodulatory treatment of interstitial lung disease.

van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712 Free PMC Article

Dupilumab: A Review of Present Indications and Off-Label Uses.

Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102

Smoking-associated interstitial lung disease: update and review.

Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511

See all (418)

Prognosis

Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089

Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.

Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537

Eosinophilic Pneumonias.

Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405

Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.

De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Pulmonary eosinophilia.

Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481

See all (166)

Clinical prediction guides

Acute eosinophilic pneumonia in twins.

Ichihara S, Komiya K, Yamatani I, Omori S, Umeki K, Hiramatsu K, Kadota JI
Respir Investig 2023 Jan;61(1):1-4. Epub 2022 Nov 16 doi: 10.1016/j.resinv.2022.10.004. PMID: 36400689

How Can Dupilumab Cause Eosinophilic Pneumonia?

Kurihara M, Masaki K, Matsuyama E, Fujioka M, Hayashi R, Tomiyasu S, Sasahara K, Sunata K, Asaoka M, Akiyama Y, Nishie M, Irie M, Tanosaki T, Kabata H, Fukunaga K
Biomolecules 2022 Nov 23;12(12) doi: 10.3390/biom12121743. PMID: 36551171 Free PMC Article

Eosinophilia Induced by Blocking the IL-4/IL-13 Pathway: Potential Mechanisms and Clinical Outcomes.

Olaguibel JM, Sastre J, Rodríguez JM, Del Pozo V
J Investig Allergol Clin Immunol 2022 Jun 20;32(3):165-180. Epub 2022 May 6 doi: 10.18176/jiaci.0823. PMID: 35522053

Drug-induced eosinophilic pneumonia: A review of 196 case reports.

Bartal C, Sagy I, Barski L
Medicine (Baltimore) 2018 Jan;97(4):e9688. doi: 10.1097/MD.0000000000009688. PMID: 29369189 Free PMC Article

Amiodarone: review of pulmonary effects and toxicity.

Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

See all (115)

Recent systematic reviews

Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review.

Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L
Chemotherapy 2024;69(2):85-99. Epub 2023 Nov 14 doi: 10.1159/000535190. PMID: 37963447

COVID-19 mimics on chest CT: a pictorial review and radiologic guide.

Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, Verma N, Meirelles GSP, Marchiori E
Br J Radiol 2021 Feb 1;94(1118):20200703. Epub 2020 Dec 9 doi: 10.1259/bjr.20200703. PMID: 33296607 Free PMC Article

The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis.

Akiyama S, Yamada A, Micic D, Sakuraba A
J Am Acad Dermatol 2021 Mar;84(3):676-690. Epub 2020 Aug 11 doi: 10.1016/j.jaad.2020.08.026. PMID: 32791083 Free PMC Article

Acute eosinophilic pneumonia associated with non-cigarette smoking products: a systematic review.

Chaaban T
Adv Respir Med 2020;88(2):142-146. doi: 10.5603/ARM.2020.0088. PMID: 32383466

See all (4)

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Eosinophilic pneumonia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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