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Lower Limb Soft Tissue Necrotic Lesion

MedGen UID:
305635
•Concept ID:
C1698668
•
Disease or Syndrome

Definition

A necrotic process affecting the soft tissues of the lower extremity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLower Limb Soft Tissue Necrotic Lesion

Recent clinical studies

Etiology

Soft tissue solitary fibrous tumors of the musculoskeletal system: spectrum of MRI appearances and characteristic imaging features.
Swami VG, Demicco EG, Naraghi A, White LM
Skeletal Radiol 2022 Apr;51(4):807-817. Epub 2021 Aug 25 doi: 10.1007/s00256-021-03894-6. PMID: 34430995
Clinical presentations of Kingella kingae musculoskeletal infections in South Australian children.
Awwad E, Tolley M, Antoniou G, Williams N
J Paediatr Child Health 2021 Aug;57(8):1196-1200. Epub 2021 Mar 3 doi: 10.1111/jpc.15422. PMID: 33655677
Low Frequency of Staphylococcus Aureus in Lower Extremity Skin and Soft Tissue Infections.
Tanveer F, Bhargava A, Riederer K, Johnson LB, Khatib R
Am J Med Sci 2018 Dec;356(6):528-530. Epub 2018 Sep 21 doi: 10.1016/j.amjms.2018.09.005. PMID: 30342716
Major Histopathologic Diagnoses of Chronic Wounds.
Turi GK, Donovan V, DiGregorio J, Criscitelli TM, Kashan B, Barrientos S, Balingcongan JR, Gorenstein S, Brem H
Adv Skin Wound Care 2016 Aug;29(8):376-82. doi: 10.1097/01.ASW.0000484665.45022.b3. PMID: 27429243
Lower extremity soft tissue reconstruction with free flap based on subscapular artery.
Karşıdağ S, Akçal A, Turgut G, Uğurlu K, Baş L
Acta Orthop Traumatol Turc 2011;45(2):100-8. doi: 10.3944/AOTT.2011.2261. PMID: 21610308

Diagnosis

Morel-Lavallée Lesion in a 35-year Female.
Sohail AH, Liaquat MT, Sohail MS, Khan MS, Hakmi H
J Coll Physicians Surg Pak 2021 Mar;31(3):342-345. doi: 10.29271/jcpsp.2021.03.342. PMID: 33775030
Man with leg rash.
Hwang MH, Khesbak Z, Liu YT
Emerg Med J 2017 Oct;34(10):686-691. doi: 10.1136/emermed-2016-206523. PMID: 28963378
Major Histopathologic Diagnoses of Chronic Wounds.
Turi GK, Donovan V, DiGregorio J, Criscitelli TM, Kashan B, Barrientos S, Balingcongan JR, Gorenstein S, Brem H
Adv Skin Wound Care 2016 Aug;29(8):376-82. doi: 10.1097/01.ASW.0000484665.45022.b3. PMID: 27429243
Fat necrosis.
Canteli B, Saez F, de los Ríos A, Alvarez C
Skeletal Radiol 1996 Apr;25(3):305-7. doi: 10.1007/s002560050086. PMID: 8741074
Focal myositis.
Heffner RR Jr, Armbrustmacher VW, Earle KM
Cancer 1977 Jul;40(1):301-6. doi: 10.1002/1097-0142(197707)40:1<301::aid-cncr2820400142>3.0.co;2-n. PMID: 880559

Therapy

Delayed diagnosis and management of necrotizing fasciitis of the left lower leg: A case report.
Zhang LX, Liang ZJ, Zhao BY, Shi XW, Zhang T, Liu H, Yu XH
Medicine (Baltimore) 2022 Oct 28;101(43):e31231. doi: 10.1097/MD.0000000000031231. PMID: 36316936Free PMC Article
Angiosomal Vascular Occlusions, Deep-Tissue Pressure Injuries, and Competing Theories: A Case Report.
Yap TL, Alderden J, Lewis M, Taylor K, Fife CE
Adv Skin Wound Care 2021 Mar 1;34(3):157-164. doi: 10.1097/01.ASW.0000732804.13066.30. PMID: 33587477
Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia - Case report and literature review.
Ghasoub R, Albattah A, Elazzazy S, Alokka R, Nemir A, Alhijji I, Taha R
J Oncol Pharm Pract 2020 Mar;26(2):487-491. Epub 2019 Jun 19 doi: 10.1177/1078155219856422. PMID: 31216242
Limb desmoid tumors: a possible role for isolated limb perfusion with tumor necrosis factor-alpha and melphalan.
Lev-Chelouche D, Abu-Abeid S, Nakache R, Issakov J, Kollander Y, Merimsky O, Meller I, Klausner JM, Gutman M
Surgery 1999 Nov;126(5):963-7. doi: 10.1016/s0039-6060(99)70039-5. PMID: 10568198
High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation.
Gutman M, Inbar M, Lev-Shlush D, Abu-Abid S, Mozes M, Chaitchik S, Meller I, Klausner JM
Cancer 1997 Mar 15;79(6):1129-37. doi: 10.1002/(sici)1097-0142(19970315)79:6<1129::aid-cncr11>3.0.co;2-1. PMID: 9070490

Prognosis

Low Frequency of Staphylococcus Aureus in Lower Extremity Skin and Soft Tissue Infections.
Tanveer F, Bhargava A, Riederer K, Johnson LB, Khatib R
Am J Med Sci 2018 Dec;356(6):528-530. Epub 2018 Sep 21 doi: 10.1016/j.amjms.2018.09.005. PMID: 30342716
Major Histopathologic Diagnoses of Chronic Wounds.
Turi GK, Donovan V, DiGregorio J, Criscitelli TM, Kashan B, Barrientos S, Balingcongan JR, Gorenstein S, Brem H
Adv Skin Wound Care 2016 Aug;29(8):376-82. doi: 10.1097/01.ASW.0000484665.45022.b3. PMID: 27429243
Reconstruction of the soft tissue defects of foot and ankle with neural-island flaps: mono-institutional case series.
Sonmez E, Safak T
J Reconstr Microsurg 2011 Sep;27(7):403-8. Epub 2011 Jun 29 doi: 10.1055/s-0031-1281514. PMID: 21717389
Lower extremity soft tissue reconstruction with free flap based on subscapular artery.
Karşıdağ S, Akçal A, Turgut G, Uğurlu K, Baş L
Acta Orthop Traumatol Turc 2011;45(2):100-8. doi: 10.3944/AOTT.2011.2261. PMID: 21610308
Extraskeletal neoplasm resembling Ewing's sarcoma.
Angervall L, Enzinger FM
Cancer 1975 Jul;36(1):240-51. doi: 10.1002/1097-0142(197507)36:1<240::aid-cncr2820360127>3.0.co;2-h. PMID: 1203852

Clinical prediction guides

Soft tissue solitary fibrous tumors of the musculoskeletal system: spectrum of MRI appearances and characteristic imaging features.
Swami VG, Demicco EG, Naraghi A, White LM
Skeletal Radiol 2022 Apr;51(4):807-817. Epub 2021 Aug 25 doi: 10.1007/s00256-021-03894-6. PMID: 34430995
Analysis of bone transport for ankle arthrodesis as a limb salvage procedure for the treatment of septic pilon fracture nonunion.
Rosteius T, Lotzien S, Königshausen M, Rausch V, Cibura C, Behr B, Lehnhardt M, Schildhauer TA, Geßmann J
Sci Rep 2021 Dec 28;11(1):24472. doi: 10.1038/s41598-021-04187-7. PMID: 34963691Free PMC Article
Calcific Myonecrosis of the Leg: A Rare Entity.
Angelini A, Mavrogenis AF, Pagliarini E, Trovarelli G, Fanelli GN, Cappellesso R, Ruggieri P
Medicina (Kaunas) 2019 Aug 28;55(9) doi: 10.3390/medicina55090542. PMID: 31466356Free PMC Article
Low Frequency of Staphylococcus Aureus in Lower Extremity Skin and Soft Tissue Infections.
Tanveer F, Bhargava A, Riederer K, Johnson LB, Khatib R
Am J Med Sci 2018 Dec;356(6):528-530. Epub 2018 Sep 21 doi: 10.1016/j.amjms.2018.09.005. PMID: 30342716
Lower extremity soft tissue reconstruction with free flap based on subscapular artery.
Karşıdağ S, Akçal A, Turgut G, Uğurlu K, Baş L
Acta Orthop Traumatol Turc 2011;45(2):100-8. doi: 10.3944/AOTT.2011.2261. PMID: 21610308

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