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Densely Granulated Lactotroph Pituitary Neuroendocrine Tumor

MedGen UID:
310675
•Concept ID:
C1707674
•
Neoplastic Process
Synonyms: Densely Granulated Lactotroph PitNET/Adenoma; Densely Granulated Lactotroph Pituitary Neuroendocrine Tumor/Adenoma; Densely Granulated Pituitary Gland Lactotroph Adenoma

Definition

A rare prolactin-producing pituitary neuroendocrine tumor composed of acidophilic cells with many large secretory granules. The endoplasmic reticulum is not as abundant as in the sparsely granulated subtype. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDensely Granulated Lactotroph Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Pathological diversity in clinical syndromes of pituitary hypersecretion: its significance in evaluating their surgical treatment.
Smyth HS
Can J Neurol Sci 1985 Nov;12(4):358-62. doi: 10.1017/s0317167100035538. PMID: 4084878

Recent clinical studies

Etiology

The Value of ER∝ in the Prognosis of GH- and PRL-Secreting PitNETs: Clinicopathological Correlations.
Dumitriu-Stan RI, Burcea IF, Nastase VN, Ceaușu RA, Dumitrascu A, Cocosila LC, Bastian A, Zurac S, Raica M, Poiana C
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216162. PMID: 38003353Free PMC Article
Outcomes of Endoscopic Transsphenoidal Approach for More Aggressive Pediatric Pituitary Adenomas: Early- and Late-Term Results from a Single Center Experience.
Caklili M, Yilmaz E, Duman Ozturk S, Uzuner A, Yildirim P, Cizmecioglu Jones FM, Tas A, Cabuk B, Anik I, Ceylan S
World Neurosurg 2023 Aug;176:e623-e633. Epub 2023 Jun 2 doi: 10.1016/j.wneu.2023.05.111. PMID: 37271260
Frequency and Role of CDKN2A Deletion in High-Risk Pituitary Neuroendocrine Tumors.
Kara M, Tokat F, Pamir MN, Danyeli AE
Endocr Pathol 2020 Jun;31(2):166-173. doi: 10.1007/s12022-020-09609-2. PMID: 32157655
An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors.
Alshaikh OM, Asa SL, Mete O, Ezzat S
Endocr Pathol 2019 Jun;30(2):118-127. doi: 10.1007/s12022-019-9568-5. PMID: 30706322
Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.
Mete O, Alshaikh OM, Cintosun A, Ezzat S, Asa SL
Endocr Pathol 2018 Dec;29(4):332-338. doi: 10.1007/s12022-018-9545-4. PMID: 30215160

Diagnosis

The Value of ER∝ in the Prognosis of GH- and PRL-Secreting PitNETs: Clinicopathological Correlations.
Dumitriu-Stan RI, Burcea IF, Nastase VN, Ceaușu RA, Dumitrascu A, Cocosila LC, Bastian A, Zurac S, Raica M, Poiana C
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216162. PMID: 38003353Free PMC Article
Outcomes of Endoscopic Transsphenoidal Approach for More Aggressive Pediatric Pituitary Adenomas: Early- and Late-Term Results from a Single Center Experience.
Caklili M, Yilmaz E, Duman Ozturk S, Uzuner A, Yildirim P, Cizmecioglu Jones FM, Tas A, Cabuk B, Anik I, Ceylan S
World Neurosurg 2023 Aug;176:e623-e633. Epub 2023 Jun 2 doi: 10.1016/j.wneu.2023.05.111. PMID: 37271260
Mixed Sparsely Granulated Lactotroph and Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor Expands the Spectrum of Neuroendocrine Neoplasms in Ovarian Teratomas: the Role of Pituitary Neuroendocrine Cell Lineage Biomarkers.
Hodgson A, Pakbaz S, Shenouda C, Francis JA, Mete O
Endocr Pathol 2020 Sep;31(3):315-319. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09639-w. PMID: 32632841
An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors.
Alshaikh OM, Asa SL, Mete O, Ezzat S
Endocr Pathol 2019 Jun;30(2):118-127. doi: 10.1007/s12022-019-9568-5. PMID: 30706322
Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.
Mete O, Alshaikh OM, Cintosun A, Ezzat S, Asa SL
Endocr Pathol 2018 Dec;29(4):332-338. doi: 10.1007/s12022-018-9545-4. PMID: 30215160

Therapy

An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors.
Alshaikh OM, Asa SL, Mete O, Ezzat S
Endocr Pathol 2019 Jun;30(2):118-127. doi: 10.1007/s12022-019-9568-5. PMID: 30706322

Prognosis

The Value of ER∝ in the Prognosis of GH- and PRL-Secreting PitNETs: Clinicopathological Correlations.
Dumitriu-Stan RI, Burcea IF, Nastase VN, Ceaușu RA, Dumitrascu A, Cocosila LC, Bastian A, Zurac S, Raica M, Poiana C
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216162. PMID: 38003353Free PMC Article
Pathology of prolactinomas: any predictive value?
Lopes MBS
Pituitary 2020 Feb;23(1):3-8. doi: 10.1007/s11102-019-00997-1. PMID: 31641970
An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors.
Alshaikh OM, Asa SL, Mete O, Ezzat S
Endocr Pathol 2019 Jun;30(2):118-127. doi: 10.1007/s12022-019-9568-5. PMID: 30706322
Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.
Mete O, Alshaikh OM, Cintosun A, Ezzat S, Asa SL
Endocr Pathol 2018 Dec;29(4):332-338. doi: 10.1007/s12022-018-9545-4. PMID: 30215160
Secretory granules of pituitary adenomas: quantitative study of hormonal antigenicity.
Kamitani H, Masuzawa H, Kanazawa I, Kubo T
Acta Neuropathol 2000 Mar;99(3):263-70. doi: 10.1007/pl00007436. PMID: 10663968

Clinical prediction guides

The Value of ER∝ in the Prognosis of GH- and PRL-Secreting PitNETs: Clinicopathological Correlations.
Dumitriu-Stan RI, Burcea IF, Nastase VN, Ceaușu RA, Dumitrascu A, Cocosila LC, Bastian A, Zurac S, Raica M, Poiana C
Int J Mol Sci 2023 Nov 10;24(22) doi: 10.3390/ijms242216162. PMID: 38003353Free PMC Article
Pathology of prolactinomas: any predictive value?
Lopes MBS
Pituitary 2020 Feb;23(1):3-8. doi: 10.1007/s11102-019-00997-1. PMID: 31641970
An Institutional Experience of Tumor Progression to Pituitary Carcinoma in a 15-Year Cohort of 1055 Consecutive Pituitary Neuroendocrine Tumors.
Alshaikh OM, Asa SL, Mete O, Ezzat S
Endocr Pathol 2019 Jun;30(2):118-127. doi: 10.1007/s12022-019-9568-5. PMID: 30706322
Synchronous Multiple Pituitary Neuroendocrine Tumors of Different Cell Lineages.
Mete O, Alshaikh OM, Cintosun A, Ezzat S, Asa SL
Endocr Pathol 2018 Dec;29(4):332-338. doi: 10.1007/s12022-018-9545-4. PMID: 30215160
Secretory granules of pituitary adenomas: quantitative study of hormonal antigenicity.
Kamitani H, Masuzawa H, Kanazawa I, Kubo T
Acta Neuropathol 2000 Mar;99(3):263-70. doi: 10.1007/pl00007436. PMID: 10663968

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