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Pleural biphasic mesothelioma

MedGen UID:
311130
•Concept ID:
C1709570
•
Neoplastic Process
Synonyms: Pleural Biphasic Mesothelioma; pleural biphasic mesothelioma
 
Monarch Initiative: MONDO:0006377

Definition

Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural biphasic mesothelioma

Professional guidelines

PubMed

Multimodality Therapy in Patients With Primary Pericardial Mesothelioma.
Offin M, De Silva DL, Sauter JL, Egger JV, Yorke E, Adusumilli PS, Rimner A, Rusch VW, Zauderer MG
J Thorac Oncol 2022 Dec;17(12):1428-1432. Epub 2022 Sep 6 doi: 10.1016/j.jtho.2022.08.017. PMID: 36075530Free PMC Article
Treatment of malignant pleural mesothelioma with chemotherapy preceding versus after surgical resection.
Verma V, Ahern CA, Berlind CG, Lindsay WD, Grover S, Friedberg JS, Simone CB 2nd
J Thorac Cardiovasc Surg 2019 Feb;157(2):758-766.e1. Epub 2018 Oct 22 doi: 10.1016/j.jtcvs.2018.10.039. PMID: 30454981
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Pericardial Mesotheliomas.
Arrossi AV
Adv Anat Pathol 2023 Jul 1;30(4):253-258. Epub 2023 Apr 27 doi: 10.1097/PAP.0000000000000399. PMID: 37104724
Multicenter study of diffuse pleural mesothelioma. Histopathological and immunohistochemical features.
Poleri C, Acosta Haab G, Falcoff N, Guman G, Dalurzo L, Iotti A, Martín ME, Olmedo G, Rayá M, Reginatto A, Werbach A, Demelli G, Labanca MJ, Leguina L, Mora MF
Medicina (B Aires) 2022;82(2):210-216. PMID: 35417384
Imaging in pleural mesothelioma: A review of the 15th International Conference of the International Mesothelioma Interest Group.
Armato SG, Nowak AK, Francis RJ, Katz SI, Kholmatov M, Blyth KG, Gudmundsson E, Kidd AC, Gill RR
Lung Cancer 2022 Feb;164:76-83. Epub 2021 Dec 16 doi: 10.1016/j.lungcan.2021.12.008. PMID: 35042132
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
What's new in mesothelioma.
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910

Diagnosis

Pericardial Mesotheliomas.
Arrossi AV
Adv Anat Pathol 2023 Jul 1;30(4):253-258. Epub 2023 Apr 27 doi: 10.1097/PAP.0000000000000399. PMID: 37104724
Pleural mesothelioma.
Porcel JM
Med Clin (Barc) 2022 Sep 9;159(5):240-247. Epub 2022 May 27 doi: 10.1016/j.medcli.2022.03.007. PMID: 35636988
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Pleural mesothelioma classification update.
Beasley MB, Galateau-Salle F, Dacic S
Virchows Arch 2021 Jan;478(1):59-72. Epub 2021 Jan 21 doi: 10.1007/s00428-021-03031-7. PMID: 33475835

Therapy

Outcomes of pleurectomy decortication in patients with biphasic mesothelioma.
Lapidot M, Mazzola E, Bueno R
J Thorac Cardiovasc Surg 2022 Nov;164(5):1340-1348.e3. Epub 2022 Mar 30 doi: 10.1016/j.jtcvs.2022.01.054. PMID: 35513907
Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma.
Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, Gao Y, O'Byrne KJ, Cuffe S, Finn SP, Gray SG
Int J Oncol 2017 Mar;50(3):1044-1052. Epub 2017 Feb 9 doi: 10.3892/ijo.2017.3870. PMID: 28197626
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials.
Mansfield AS, Symanowski JT, Peikert T
Lung Cancer 2014 Nov;86(2):133-6. Epub 2014 Sep 1 doi: 10.1016/j.lungcan.2014.08.017. PMID: 25217189Free PMC Article
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Post-irradiation malignant mesothelioma.
Cavazza A, Travis LB, Travis WD, Wolfe JT 3rd, Foo ML, Gillespie DJ, Weidner N, Colby TV
Cancer 1996 Apr 1;77(7):1379-85. doi: 10.1002/(SICI)1097-0142(19960401)77:7<1379::AID-CNCR24>3.0.CO;2-Y. PMID: 8608519

Prognosis

Pericardial Mesotheliomas.
Arrossi AV
Adv Anat Pathol 2023 Jul 1;30(4):253-258. Epub 2023 Apr 27 doi: 10.1097/PAP.0000000000000399. PMID: 37104724
Pleural mesothelioma.
Porcel JM
Med Clin (Barc) 2022 Sep 9;159(5):240-247. Epub 2022 May 27 doi: 10.1016/j.medcli.2022.03.007. PMID: 35636988
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
What's new in mesothelioma.
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910

Clinical prediction guides

Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape.
Dagogo-Jack I, Madison RW, Lennerz JK, Chen KT, Hopkins JF, Schrock AB, Ritterhouse LL, Lester A, Wharton KA Jr, Mino-Kenudson M, Danziger N, Hung YP, Mata DA, Ross JS
JCO Precis Oncol 2022 Jun;6:e2100422. doi: 10.1200/PO.21.00422. PMID: 35704798
Multicenter study of diffuse pleural mesothelioma. Histopathological and immunohistochemical features.
Poleri C, Acosta Haab G, Falcoff N, Guman G, Dalurzo L, Iotti A, Martín ME, Olmedo G, Rayá M, Reginatto A, Werbach A, Demelli G, Labanca MJ, Leguina L, Mora MF
Medicina (B Aires) 2022;82(2):210-216. PMID: 35417384
What's new in mesothelioma.
Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L
Pathologica 2018 Mar;110(1):12-28. PMID: 30259910
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations.
Bueno R, Stawiski EW, Goldstein LD, Durinck S, De Rienzo A, Modrusan Z, Gnad F, Nguyen TT, Jaiswal BS, Chirieac LR, Sciaranghella D, Dao N, Gustafson CE, Munir KJ, Hackney JA, Chaudhuri A, Gupta R, Guillory J, Toy K, Ha C, Chen YJ, Stinson J, Chaudhuri S, Zhang N, Wu TD, Sugarbaker DJ, de Sauvage FJ, Richards WG, Seshagiri S
Nat Genet 2016 Apr;48(4):407-16. Epub 2016 Feb 29 doi: 10.1038/ng.3520. PMID: 26928227
The established and future biomarkers of malignant pleural mesothelioma.
Panou V, Vyberg M, Weinreich UM, Meristoudis C, Falkmer UG, Røe OD
Cancer Treat Rev 2015 Jun;41(6):486-95. Epub 2015 May 8 doi: 10.1016/j.ctrv.2015.05.001. PMID: 25979846

Recent systematic reviews

Pathology of Malignant Pleural Mesothelioma.
Hung YP, Chirieac LR
Thorac Surg Clin 2020 Nov;30(4):367-382. doi: 10.1016/j.thorsurg.2020.08.007. PMID: 33012427
Systematic review of response rates of sarcomatoid malignant pleural mesotheliomas in clinical trials.
Mansfield AS, Symanowski JT, Peikert T
Lung Cancer 2014 Nov;86(2):133-6. Epub 2014 Sep 1 doi: 10.1016/j.lungcan.2014.08.017. PMID: 25217189Free PMC Article

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