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Breast Columnar Cell Hyperplasia with Atypia

MedGen UID:
317528
•Concept ID:
C1707447
•
Neoplastic Process
Synonyms: Columnar Cell Hyperplasia of Breast with Atypia; Columnar Cell Hyperplasia of the Breast with Atypia

Definition

A columnar cell lesion characterized by the presence of enlarged terminal ductal lobular units with dilated acini. The acini are lined by more than two layers of columnar epithelial cells. Cytologic atypia is present. Prominent apical cytoplasmic snouts and intraluminal secretions are also present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Columnar Cell Hyperplasia with Atypia

Professional guidelines

PubMed

Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.
Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037Free PMC Article

Recent clinical studies

Etiology

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Precursor Lesions of the Low-Grade Breast Neoplasia Pathway.
Collins LC
Surg Pathol Clin 2018 Mar;11(1):177-197. Epub 2017 Dec 8 doi: 10.1016/j.path.2017.09.007. PMID: 29413656
Atypical epithelial hyperplasia of the breast: state of the art.
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571
Columnar cell lesions of the breast: an update and significance on core biopsy.
Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736
Non-operative breast pathology: columnar cell lesions.
Pinder SE, Reis-Filho JS
J Clin Pathol 2007 Dec;60(12):1307-12. Epub 2006 Dec 20 doi: 10.1136/jcp.2006.040634. PMID: 17182657Free PMC Article

Diagnosis

Papillomatous breast lesions with atypical columnar cell features.
de Boer M, Verschuur-Maes AHJ, Moelans C, van Diest PJ
J Clin Pathol 2023 Apr;76(4):228-233. Epub 2023 Jan 24 doi: 10.1136/jcp-2022-208389. PMID: 36693714
Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Blunt duct adenosis: a separate entity from columnar cell lesions?
de Boer M, van Diest PJ
J Clin Pathol 2022 Jan;75(1):5-9. Epub 2021 Apr 15 doi: 10.1136/jclinpath-2020-207359. PMID: 33858936Free PMC Article
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Atypical epithelial hyperplasia of the breast: state of the art.
Dion L, Racin A, Brousse S, Beltjens F, Cauchois A, Levêque J, Coutant C, Lavoué V
Expert Rev Anticancer Ther 2016 Sep;16(9):943-53. Epub 2016 Jul 5 doi: 10.1080/14737140.2016.1204916. PMID: 27367571

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.
Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540Free PMC Article
Postoperative spindle cell nodule of the breast: Pseudosarcomatous myofibroblastic proliferation following endo-surgery.
Garijo MF, Val-Bernal JF, Vega A, Val D
Pathol Int 2008 Dec;58(12):787-91. doi: 10.1111/j.1440-1827.2008.02312.x. PMID: 19067854

Prognosis

Histopathologic Features of Breast Tissue From Transgender Men and Their Associations With Androgen Therapy.
Wolters EA, Rabe KE, Siegel L, Butts J, Klein ME
Am J Clin Pathol 2023 Jan 4;159(1):43-52. doi: 10.1093/ajcp/aqac123. PMID: 36469057Free PMC Article
Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?
Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185Free PMC Article
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Flat epithelial atypia and risk of breast cancer: A Mayo cohort study.
Said SM, Visscher DW, Nassar A, Frank RD, Vierkant RA, Frost MH, Ghosh K, Radisky DC, Hartmann LC, Degnim AC
Cancer 2015 May 15;121(10):1548-55. Epub 2015 Jan 13 doi: 10.1002/cncr.29243. PMID: 25639678Free PMC Article
Columnar cell lesions without atypia initially diagnosed on breast needle biopsies: is imaging follow-up enough?
Seo M, Chang JM, Kim WH, Park IA, Lee SH, Cho N, Moon WK
AJR Am J Roentgenol 2013 Oct;201(4):928-34. doi: 10.2214/AJR.12.9906. PMID: 24059386

Clinical prediction guides

Histopathologic Features of Breast Tissue From Transgender Men and Their Associations With Androgen Therapy.
Wolters EA, Rabe KE, Siegel L, Butts J, Klein ME
Am J Clin Pathol 2023 Jan 4;159(1):43-52. doi: 10.1093/ajcp/aqac123. PMID: 36469057Free PMC Article
Risk factors for breast cancer development by tumor characteristics among women with benign breast disease.
Figueroa JD, Gierach GL, Duggan MA, Fan S, Pfeiffer RM, Wang Y, Falk RT, Loudig O, Abubakar M, Ginsberg M, Kimes TM, Richert-Boe K, Glass AG, Rohan TE
Breast Cancer Res 2021 Mar 18;23(1):34. doi: 10.1186/s13058-021-01410-1. PMID: 33736682Free PMC Article
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436
Non-operative breast pathology: columnar cell lesions.
Pinder SE, Reis-Filho JS
J Clin Pathol 2007 Dec;60(12):1307-12. Epub 2006 Dec 20 doi: 10.1136/jcp.2006.040634. PMID: 17182657Free PMC Article

Recent systematic reviews

Columnar cell lesions on breast needle biopsies: is surgical excision necessary? A systematic review.
Verschuur-Maes AH, van Deurzen CH, Monninkhof EM, van Diest PJ
Ann Surg 2012 Feb;255(2):259-65. doi: 10.1097/SLA.0b013e318233523f. PMID: 21989373

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