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Non-Neoplastic Pancreatic Disorder

MedGen UID:
317959
•Concept ID:
C1709252
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the pancreas. Representative examples include pancreatitis and pancreatic insufficiency. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Pancreatic Disorder

Professional guidelines

PubMed

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Pancreatic cystic lesions. Differential diagnosis and treatment strategy.
Lira-Treviño A, Carranza Mendoza IG, Borbolla Arizti JP, Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M
Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):188-197. Epub 2022 May 21 doi: 10.1016/j.rgmxen.2022.05.002. PMID: 35610168
Management of pancreatic cysts: a review of the current guidelines.
Hol L, Signoretti M, Poley JW
Minerva Gastroenterol Dietol 2015 Jun;61(2):87-99. Epub 2015 Feb 5 PMID: 25651835

Recent clinical studies

Etiology

Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion.
Jeong YJ, Knutsdottir H, Shojaeian F, Lerner MG, Wissler MF, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Köster B, Zimmerman JW, Stein-O'Brien G, Gaida MM, Eshleman JR, Lin MT, Fertig EJ, Ewald AJ, Bader JS, Wood LD
J Clin Invest 2023 Apr 17;133(8) doi: 10.1172/JCI162054. PMID: 36881486Free PMC Article
Pancreatic cystic lesions. Differential diagnosis and treatment strategy.
Lira-Treviño A, Carranza Mendoza IG, Borbolla Arizti JP, Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M
Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):188-197. Epub 2022 May 21 doi: 10.1016/j.rgmxen.2022.05.002. PMID: 35610168
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Uncommon pancreatic tumors and pseudotumors.
Lalwani N, Mannelli L, Ganeshan DM, Shanbhogue AK, Dighe MK, Tiwari HA, Maximin S, Monti S, Ragucci M, Prasad SR
Abdom Imaging 2015 Jan;40(1):167-80. doi: 10.1007/s00261-014-0189-7. PMID: 25063236
Hepatobiliary and pancreatic imaging in children-techniques and an overview of non-neoplastic disease entities.
Nievelstein RA, Robben SG, Blickman JG
Pediatr Radiol 2011 Jan;41(1):55-75. Epub 2010 Oct 22 doi: 10.1007/s00247-010-1858-5. PMID: 20967540Free PMC Article

Diagnosis

Pancreatic cystic lesions. Differential diagnosis and treatment strategy.
Lira-Treviño A, Carranza Mendoza IG, Borbolla Arizti JP, Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M
Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):188-197. Epub 2022 May 21 doi: 10.1016/j.rgmxen.2022.05.002. PMID: 35610168
Cystic pancreatic lesions, the endless dilemma.
Okasha HH, Awad A, El-Meligui A, Ezzat R, Aboubakr A, AbouElenin S, El-Husseiny R, Alzamzamy A
World J Gastroenterol 2021 Jun 7;27(21):2664-2680. doi: 10.3748/wjg.v27.i21.2664. PMID: 34135548Free PMC Article
Non-Neoplastic Masses of the Pancreas.
Centeno BA, Thomas SC
Monogr Clin Cytol 2020;26:42-52. Epub 2020 Sep 28 doi: 10.1159/000455734. PMID: 32987396
Non-Neoplastic and Neoplastic Cysts of the Pancreas.
Centeno BA, Thomas SC
Monogr Clin Cytol 2020;26:53-73. Epub 2020 Sep 28 doi: 10.1159/000455735. PMID: 32987387
Non-neoplastic pancreatic lesions that may mimic malignancy.
Okun SD, Lewin DN
Semin Diagn Pathol 2016 Jan;33(1):31-42. Epub 2015 Sep 7 doi: 10.1053/j.semdp.2015.09.005. PMID: 26602569

Therapy

The tumor microenvironment in pancreatic ductal adenocarcinoma: current perspectives and future directions.
Herting CJ, Karpovsky I, Lesinski GB
Cancer Metastasis Rev 2021 Sep;40(3):675-689. doi: 10.1007/s10555-021-09988-w. PMID: 34591240
Dietary intake of branched-chain amino acids and colorectal cancer risk.
Rossi M, Mascaretti F, Parpinel M, Serraino D, Crispo A, Celentano E, Giacosa A, La Vecchia C
Br J Nutr 2021 Jul 14;126(1):22-27. Epub 2020 Sep 23 doi: 10.1017/S0007114520003724. PMID: 32962776
Snus: a compelling harm reduction alternative to cigarettes.
Clarke E, Thompson K, Weaver S, Thompson J, O'Connell G
Harm Reduct J 2019 Nov 27;16(1):62. doi: 10.1186/s12954-019-0335-1. PMID: 31775744Free PMC Article
Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity.
Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H
J Gastrointest Surg 2014 Mar;18(3):523-31. Epub 2014 Jan 22 doi: 10.1007/s11605-014-2459-7. PMID: 24449000
Metabolic syndrome and pancreatic cancer risk: a case-control study in Italy and meta-analysis.
Rosato V, Tavani A, Bosetti C, Pelucchi C, Talamini R, Polesel J, Serraino D, Negri E, La Vecchia C
Metabolism 2011 Oct;60(10):1372-8. Epub 2011 May 6 doi: 10.1016/j.metabol.2011.03.005. PMID: 21550085

Prognosis

Microenvironmental Determinants of Pancreatic Cancer.
Hessmann E, Buchholz SM, Demir IE, Singh SK, Gress TM, Ellenrieder V, Neesse A
Physiol Rev 2020 Oct 1;100(4):1707-1751. Epub 2020 Apr 16 doi: 10.1152/physrev.00042.2019. PMID: 32297835
Snus: a compelling harm reduction alternative to cigarettes.
Clarke E, Thompson K, Weaver S, Thompson J, O'Connell G
Harm Reduct J 2019 Nov 27;16(1):62. doi: 10.1186/s12954-019-0335-1. PMID: 31775744Free PMC Article
Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.
Klöppel G, La Rosa S
Virchows Arch 2018 Mar;472(3):341-349. Epub 2017 Nov 13 doi: 10.1007/s00428-017-2258-0. PMID: 29134440
Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.
Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607
Pseudocysts and other non-neoplastic cysts of the pancreas.
Klöppel G
Semin Diagn Pathol 2000 Feb;17(1):7-15. PMID: 10721803

Clinical prediction guides

Long-term risk of venous thromboembolism among patients with gastrointestinal non-neoplastic and neoplastic diseases: A prospective cohort study of 484 211 individuals.
Yuan S, Sun Y, Chen J, Li X, Larsson SC
Am J Hematol 2024 Feb;99(2):172-181. Epub 2023 Sep 27 doi: 10.1002/ajh.27106. PMID: 37753710
Pancreatic cystic lesions and the role of contrast enhanced endoscopic ultrasound.
Hickman K, Sadler TJ, Zhang TT, Boninsegna E, Majcher V, Godfrey E
Clin Radiol 2022 Jun;77(6):418-427. Epub 2022 Apr 3 doi: 10.1016/j.crad.2022.02.017. PMID: 35387743
Co-analysis of pancreatic cyst fluid carcinoembryonic antigen and glucose with novel cut-off levels better distinguishes between mucinous and non-mucinous neoplastic pancreatic cystic lesions.
Barutcuoglu B, Oruc N, Ak G, Kucukokudan S, Aydın A, Nart D, Harman M
Ann Clin Biochem 2022 Mar;59(2):125-133. Epub 2021 Oct 31 doi: 10.1177/00045632211053998. PMID: 34719238
Age-related morphological changes in the pancreas and their association with pancreatic carcinogenesis.
Matsuda Y
Pathol Int 2019 Aug;69(8):450-462. Epub 2019 Jul 24 doi: 10.1111/pin.12837. PMID: 31339204
Obesity and metabolic syndrome: pathological effects on the gastrointestinal tract.
Feakins RM
Histopathology 2016 Apr;68(5):630-40. Epub 2016 Jan 19 doi: 10.1111/his.12907. PMID: 26599607

Recent systematic reviews

Value of Endoscopic Ultrasound-Guided Through-the-Needle Biopsy in Pancreatic Cystic Lesions. A Systematic Review and Meta-Analysis.
Gopakumar H, Puli SR
J Gastrointest Cancer 2024 Mar;55(1):15-25. Epub 2023 Jun 21 doi: 10.1007/s12029-023-00949-w. PMID: 37341913
Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring.
Luchini C, Pantanowitz L, Adsay V, Asa SL, Antonini P, Girolami I, Veronese N, Nottegar A, Cingarlini S, Landoni L, Brosens LA, Verschuur AV, Mattiolo P, Pea A, Mafficini A, Milella M, Niazi MK, Gurcan MN, Eccher A, Cree IA, Scarpa A
Mod Pathol 2022 Jun;35(6):712-720. Epub 2022 Mar 5 doi: 10.1038/s41379-022-01055-1. PMID: 35249100Free PMC Article
Value of contrast-enhanced harmonic endoscopic ultrasonography with enhancement pattern for diagnosis of pancreatic cancer: A meta-analysis.
Yamashita Y, Shimokawa T, Napoléon B, Fusaroli P, Gincul R, Kudo M, Kitano M
Dig Endosc 2019 Mar;31(2):125-133. Epub 2019 Jan 15 doi: 10.1111/den.13290. PMID: 30338569
Diagnostic performance of contrast-enhanced ultrasound (CEUS) and contrast-enhanced endoscopic ultrasound (ECEUS) for the differentiation of pancreatic lesions: a systematic review and meta-analysis.
D'Onofrio M, Biagioli E, Gerardi C, Canestrini S, Rulli E, Crosara S, De Robertis R, Floriani I
Ultraschall Med 2014 Dec;35(6):515-21. Epub 2014 Sep 16 doi: 10.1055/s-0034-1385068. PMID: 25226455

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