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Spinal arachnoiditis

MedGen UID:
318191
•Concept ID:
C1710146
•
Disease or Syndrome
Synonyms: Familial spinal arachnoiditis; Spinal tuberculous arachnoiditis
SNOMED CT: Spinal arachnoiditis (426055002)
 
Monarch Initiative: MONDO:0008450
OMIM®: 182950

Definition

A chronic adhesive arachnoiditis in the spinal arachnoid, with root and spinal cord symptoms similar to those caused by pressure from a tumor. [from NCI]

Clinical features

From HPO
Spastic paraparesis
MedGen UID:
52432
•Concept ID:
C0037771
•
Sign or Symptom
Mild or moderate loss of motor function accompanied by spasticity in the lower extremities. This condition is a manifestation of CENTRAL NERVOUS SYSTEM DISEASES that cause injury to the motor cortex or descending motor pathways.
See: Feature record | Search on this feature
Abnormality of the skeletal system
MedGen UID:
867418
•Concept ID:
C4021790
•
Anatomical Abnormality
An abnormality of the skeletal system.
See: Feature record | Search on this feature
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Treatment of syringomyelia with a syringosubarachnoid shunt.
Tator CH, Briceno C
Can J Neurol Sci 1988 Feb;15(1):48-57. doi: 10.1017/s0317167100027190. PMID: 3345462
Intrathecal hyaluronidase treatment of chronic spinal arachnoiditis of noninfective etiology.
Gourie-Devi M, Satish P
Surg Neurol 1984 Sep;22(3):231-4. doi: 10.1016/0090-3019(84)90004-1. PMID: 6547785
Lumbosacral spinal fibrosis (spinal arachnoiditis). Its diagnosis and treatment by spinal cord stimulation.
de la Porte C, Siegfried J
Spine (Phila Pa 1976) 1983 Sep;8(6):593-603. PMID: 6228017

Recent clinical studies

Etiology

Reintervention rate of arachnolysis versus shunting for nonforaminal syringomyelia.
Guillaumet G, Aghakhani N, Morar S, Copaciu R, Parker F, Knafo S
J Neurosurg Spine 2021 Feb 5;34(4):673-679. doi: 10.3171/2020.8.SPINE20928. PMID: 33545681
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
Flexible endoscopy in surgical treatment of spinal adhesive arachnoiditis and arachnoid cysts.
Kashcheev AA, Arestov SO, Gushcha AO
Zh Vopr Neirokhir Im N N Burdenko 2013;77(5):44-54; discussion 54-5. PMID: 24564085
A comprehensive review of spinal arachnoiditis.
Wright MH, Denney LC
Orthop Nurs 2003 May-Jun;22(3):215-9; quiz 220-1. doi: 10.1097/00006416-200305000-00010. PMID: 12803151
Surgery for hindbrain related syringomyelia.
Williams B
Adv Tech Stand Neurosurg 1993;20:107-64. doi: 10.1007/978-3-7091-6912-4_4. PMID: 8397533

Diagnosis

Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
Cauda equina syndrome.
Orendácová J, Cízková D, Kafka J, Lukácová N, Marsala M, Sulla I, Marsala J, Katsube N
Prog Neurobiol 2001 Aug;64(6):613-37. doi: 10.1016/s0301-0082(00)00065-4. PMID: 11311464
Syringomyelia.
Williams B
Neurosurg Clin N Am 1990 Jul;1(3):653-85. PMID: 2136163
Progress in syringomyelia.
Williams B
Neurol Res 1986 Sep;8(3):130-45. doi: 10.1080/01616412.1986.11739745. PMID: 2877406

Therapy

CNS cryptococcosis presenting with cerebellar stroke and spinal arachnoiditis.
Priyadarshi M, Tirlangi P, Kadnur H, Jadon R
BMJ Case Rep 2022 Feb 7;15(2) doi: 10.1136/bcr-2021-246824. PMID: 35131790Free PMC Article
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Paradoxical reaction in HIV negative tuberculous meningitis.
Garg RK, Malhotra HS, Kumar N
J Neurol Sci 2014 May 15;340(1-2):26-36. Epub 2014 Mar 19 doi: 10.1016/j.jns.2014.03.025. PMID: 24680563
Spinal arachnoiditis.
Esses SI, Morley TP
Can J Neurol Sci 1983 Feb;10(1):2-10. doi: 10.1017/s0317167100044486. PMID: 6404543
Chronic spinal arachnoiditis.
Br Med J 1978 Aug 19;2(6136):518-9. PMID: 698548Free PMC Article

Prognosis

"Malignant" Craniospinal Neurocysticercosis: A Rare Case.
Garg K, Vij V, Garg A, Singh M, Chandra PS
World Neurosurg 2021 Feb;146:95-102. Epub 2020 Oct 27 doi: 10.1016/j.wneu.2020.10.121. PMID: 33127574
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
A comprehensive review of spinal arachnoiditis.
Wright MH, Denney LC
Orthop Nurs 2003 May-Jun;22(3):215-9; quiz 220-1. doi: 10.1097/00006416-200305000-00010. PMID: 12803151
Surgery for hindbrain related syringomyelia.
Williams B
Adv Tech Stand Neurosurg 1993;20:107-64. doi: 10.1007/978-3-7091-6912-4_4. PMID: 8397533

Clinical prediction guides

Reasons for re-hospitalization in patients with tuberculous meningitis, and its impact on outcome: a prospective observational study.
Patil MR, Rizvi I, Garg RK, Malhotra HS, Kumar N, Uniyal R, Pandey S, Verma R, Sharma PK
Acta Neurol Belg 2023 Oct;123(5):1869-1883. Epub 2022 Oct 28 doi: 10.1007/s13760-022-02123-8. PMID: 36306031
Reintervention rate of arachnolysis versus shunting for nonforaminal syringomyelia.
Guillaumet G, Aghakhani N, Morar S, Copaciu R, Parker F, Knafo S
J Neurosurg Spine 2021 Feb 5;34(4):673-679. doi: 10.3171/2020.8.SPINE20928. PMID: 33545681
Compressive myelopathy secondary to posthemorragic arachnoiditis: Case report and literature review.
Gutiérrez ML, Rodríguez EEE, Millán JMS, Urzaiz LL, Berrocal VR
Clin Neurol Neurosurg 2020 Sep;196:105964. Epub 2020 May 26 doi: 10.1016/j.clineuro.2020.105964. PMID: 32526489
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
Spinal en plaque meningiomas: a contemporary experience.
Caroli E, Acqui M, Roperto R, Ferrante L, D'Andrea G
Neurosurgery 2004 Dec;55(6):1275-9; discussion 1279. doi: 10.1227/01.neu.0000143611.28034.b2. PMID: 15574209

Recent systematic reviews

Aspergillus meningitis: a rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases.
Antinori S, Corbellino M, Meroni L, Resta F, Sollima S, Tonolini M, Tortorano AM, Milazzo L, Bello L, Furfaro E, Galli M, Viscoli C
J Infect 2013 Mar;66(3):218-38. Epub 2012 Nov 21 doi: 10.1016/j.jinf.2012.11.003. PMID: 23178421Free PMC Article

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