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Recurrent deep vein thrombosis

MedGen UID:
319764
•Concept ID:
C1735901
•
Pathologic Function
Synonym: Venous thrombosis, recurrent
SNOMED CT: Recurrent deep vein thrombosis (710167004)
 
HPO: HP:0004850

Definition

Repeated episodes of the formation of a blot clot in a deep vein. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent deep vein thrombosis

Conditions with this feature

Heparin cofactor II deficiency
MedGen UID:
96017
•Concept ID:
C0398626
•
Disease or Syndrome
Heparin cofactor II (HCF2; 142360) rapidly inhibits thrombin in plasma in the presence of dermatan sulfate or heparin. Congenital HCF2 deficiency is associated with thromboembolism and is classified into type I (quantitative) or type II (qualitative) deficiency (Kondo et al., 1996).
See: Condition Record
Thrombophilia, familial, due to decreased release of tissue plasminogen activator
MedGen UID:
393574
•Concept ID:
C2676721
•
Disease or Syndrome
See: Condition Record
Thrombophilia due to protein C deficiency, autosomal recessive
MedGen UID:
394120
•Concept ID:
C2676759
•
Disease or Syndrome
Autosomal recessive protein C deficiency resulting from homozygous or compound heterozygous PROC mutations is a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia (Millar et al., 2000).
See: Condition Record
Heparin cofactor II deficiency
Thrombophilia due to protein C deficiency, autosomal recessive
Thrombophilia, familial, due to decreased release of tissue plasminogen activator

Professional guidelines

PubMed

ACR Appropriateness Criteria® Radiologic Management of Iliofemoral Venous Thrombosis.
Expert Panel on Interventional Radiology, Farsad K, Kapoor BS, Fidelman N, Cain TR, Caplin DM, Eldrup-Jorgensen J, Gupta A, Higgins M, Hohenwalter EJ, Lee MH, McBride JJ, Minocha J, Rochon PJ, Sutphin PD, Lorenz JM
J Am Coll Radiol 2020 May;17(5S):S255-S264. doi: 10.1016/j.jacr.2020.01.035. PMID: 32370969
Diagnosis of deep vein thrombosis recurrence: Ultrasound criteria.
Maufus M, Elias A, Barrellier MT, Pernod G; French Society for Vascular Medicine
Thromb Res 2018 Jan;161:78-83. Epub 2017 Nov 14 doi: 10.1016/j.thromres.2017.11.004. PMID: 29216479
Systematic review of anticoagulant treatment of catheter-related thrombosis.
Baumann Kreuziger L, Onwuemene O, Kolesar E, Crowther M, Lim W
Thromb Res 2015 Dec;136(6):1103-9. Epub 2015 Sep 1 doi: 10.1016/j.thromres.2015.08.020. PMID: 26342400

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

UK NICE Guideline NG158, Venous thromboembolic diseases: diagnosis, management and thrombophilia testing, 2023

Recent clinical studies

Etiology

How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Gautam G, Sebastian T, Klok FA
Hamostaseologie 2020 Aug;40(3):280-291. Epub 2020 Jul 29 doi: 10.1055/a-1171-0486. PMID: 32726823
Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review.
Byon W, Garonzik S, Boyd RA, Frost CE
Clin Pharmacokinet 2019 Oct;58(10):1265-1279. doi: 10.1007/s40262-019-00775-z. PMID: 31089975Free PMC Article
How I treat recurrent deep-vein thrombosis.
Kyrle PA
Blood 2016 Feb 11;127(6):696-702. Epub 2015 Dec 11 doi: 10.1182/blood-2015-09-671297. PMID: 26660685
Diagnosis of recurrent deep vein thrombosis.
Schellong SM
Hamostaseologie 2013 Aug 1;33(3):195-200. Epub 2013 Jul 1 doi: 10.5482/HAMO-13-06-0029. PMID: 23817606
Deep vein thrombosis: review and update.
Niranjan A, Agarwal N, Agarwal T, Agarwal M
J Indian Med Assoc 2010 Apr;108(4):248-51. PMID: 21114193

Diagnosis

How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Gautam G, Sebastian T, Klok FA
Hamostaseologie 2020 Aug;40(3):280-291. Epub 2020 Jul 29 doi: 10.1055/a-1171-0486. PMID: 32726823
Diagnosis of deep vein thrombosis recurrence: Ultrasound criteria.
Maufus M, Elias A, Barrellier MT, Pernod G; French Society for Vascular Medicine
Thromb Res 2018 Jan;161:78-83. Epub 2017 Nov 14 doi: 10.1016/j.thromres.2017.11.004. PMID: 29216479
Diagnosis of recurrent deep vein thrombosis.
Schellong SM
Hamostaseologie 2013 Aug 1;33(3):195-200. Epub 2013 Jul 1 doi: 10.5482/HAMO-13-06-0029. PMID: 23817606
Deep vein thrombosis: review and update.
Niranjan A, Agarwal N, Agarwal T, Agarwal M
J Indian Med Assoc 2010 Apr;108(4):248-51. PMID: 21114193
Antiphospholipid syndrome.
Gezer S
Dis Mon 2003 Dec;49(12):696-741. doi: 10.1016/j.disamonth.2003.10.001. PMID: 14679358

Therapy

How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Gautam G, Sebastian T, Klok FA
Hamostaseologie 2020 Aug;40(3):280-291. Epub 2020 Jul 29 doi: 10.1055/a-1171-0486. PMID: 32726823
Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review.
Byon W, Garonzik S, Boyd RA, Frost CE
Clin Pharmacokinet 2019 Oct;58(10):1265-1279. doi: 10.1007/s40262-019-00775-z. PMID: 31089975Free PMC Article
How I treat recurrent deep-vein thrombosis.
Kyrle PA
Blood 2016 Feb 11;127(6):696-702. Epub 2015 Dec 11 doi: 10.1182/blood-2015-09-671297. PMID: 26660685
Deep vein thrombosis: review and update.
Niranjan A, Agarwal N, Agarwal T, Agarwal M
J Indian Med Assoc 2010 Apr;108(4):248-51. PMID: 21114193
Diagnosis of recurrent deep vein thrombosis.
Prandoni P, Bernardi E, Tormene D, Mosena L, Sartor D, Girolami A
Semin Vasc Med 2001;1(1):55-60. doi: 10.1055/s-2001-14541. PMID: 15199514

Prognosis

Fibrinolysis in Venous Thromboembolism.
Undas A
Semin Thromb Hemost 2021 Jul;47(5):480-489. Epub 2021 Apr 20 doi: 10.1055/s-0041-1725094. PMID: 33878786
How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Gautam G, Sebastian T, Klok FA
Hamostaseologie 2020 Aug;40(3):280-291. Epub 2020 Jul 29 doi: 10.1055/a-1171-0486. PMID: 32726823
Recurrent Deep Vein Thrombosis After the First Venous Thromboembolism Event: A Single-Institution Experience.
Asim M, Al-Thani H, El-Menyar A
Med Sci Monit 2017 May 20;23:2391-2399. doi: 10.12659/msm.901924. PMID: 28527240Free PMC Article
A systematic review of clinical prediction scores for deep vein thrombosis.
Kafeza M, Shalhoub J, Salooja N, Bingham L, Spagou K, Davies AH
Phlebology 2017 Sep;32(8):516-531. Epub 2016 Nov 24 doi: 10.1177/0268355516678729. PMID: 27885107
Diagnosis of recurrent deep vein thrombosis.
Schellong SM
Hamostaseologie 2013 Aug 1;33(3):195-200. Epub 2013 Jul 1 doi: 10.5482/HAMO-13-06-0029. PMID: 23817606

Clinical prediction guides

Fibrinolysis in Venous Thromboembolism.
Undas A
Semin Thromb Hemost 2021 Jul;47(5):480-489. Epub 2021 Apr 20 doi: 10.1055/s-0041-1725094. PMID: 33878786
How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Gautam G, Sebastian T, Klok FA
Hamostaseologie 2020 Aug;40(3):280-291. Epub 2020 Jul 29 doi: 10.1055/a-1171-0486. PMID: 32726823
Recurrent Deep Vein Thrombosis After the First Venous Thromboembolism Event: A Single-Institution Experience.
Asim M, Al-Thani H, El-Menyar A
Med Sci Monit 2017 May 20;23:2391-2399. doi: 10.12659/msm.901924. PMID: 28527240Free PMC Article
A systematic review of clinical prediction scores for deep vein thrombosis.
Kafeza M, Shalhoub J, Salooja N, Bingham L, Spagou K, Davies AH
Phlebology 2017 Sep;32(8):516-531. Epub 2016 Nov 24 doi: 10.1177/0268355516678729. PMID: 27885107
Diagnosis of recurrent deep vein thrombosis.
Schellong SM
Hamostaseologie 2013 Aug 1;33(3):195-200. Epub 2013 Jul 1 doi: 10.5482/HAMO-13-06-0029. PMID: 23817606

Recent systematic reviews

Effect of statins on the risk of recurrent venous thromboembolism: A systematic review and meta-analysis.
Li R, Yuan M, Yu S, Fu W, Yu W, Ling S, Sun J, Chen Y
Pharmacol Res 2021 Mar;165:105413. Epub 2021 Jan 5 doi: 10.1016/j.phrs.2020.105413. PMID: 33412275
A systematic review of clinical prediction scores for deep vein thrombosis.
Kafeza M, Shalhoub J, Salooja N, Bingham L, Spagou K, Davies AH
Phlebology 2017 Sep;32(8):516-531. Epub 2016 Nov 24 doi: 10.1177/0268355516678729. PMID: 27885107
Systematic review of anticoagulant treatment of catheter-related thrombosis.
Baumann Kreuziger L, Onwuemene O, Kolesar E, Crowther M, Lim W
Thromb Res 2015 Dec;136(6):1103-9. Epub 2015 Sep 1 doi: 10.1016/j.thromres.2015.08.020. PMID: 26342400
Indirect treatment comparison of new oral anticoagulants for the treatment of acute venous thromboembolism.
Kang N, Sobieraj DM
Thromb Res 2014 Jun;133(6):1145-51. Epub 2014 Mar 24 doi: 10.1016/j.thromres.2014.03.035. PMID: 24713109
Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism.
Vardi M, Zittan E, Bitterman H
Cochrane Database Syst Rev 2009 Oct 7;(4):CD006771. doi: 10.1002/14651858.CD006771.pub2. PMID: 19821386

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023
    • NICE, 2023
      UK NICE Guideline NG158, Venous thromboembolic diseases: diagnosis, management and thrombophilia testing, 2023

    Consumer resources

    Reviews

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    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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