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Increased subcutaneous truncal adipose tissue

MedGen UID:
325256
•Concept ID:
C1837781
•
Finding
Synonym: Increased fat below the skin in trunk
 
HPO: HP:0009003

Definition

The presence of an abnormally increased amount of subcutaneous adipose tissue in the trunk of the body. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased subcutaneous truncal adipose tissue

Conditions with this feature

Familial partial lipodystrophy, Kobberling type
MedGen UID:
318591
•Concept ID:
C1720859
•
Disease or Syndrome
Familial partial lipodystrophy type 1 (FPLD1), or Kobberling-type lipodystrophy, is characterized by loss of adipose tissue confined to the extremities, with normal or increased distribution of fat on the face, neck, and trunk (Kobberling and Dunnigan, 1986). For a general description and a discussion of genetic heterogeneity of familial partial lipodystrophy (FPLD), see 151660.
See: Condition Record
Familial partial lipodystrophy, Kobberling type

Recent clinical studies

Etiology

Impaired postprandial adipose tissue microvascular blood flow responses to a mixed-nutrient meal in first-degree relatives of adults with type 2 diabetes.
Roberts-Thomson KM, Hu D, Russell RD, Greenaway T, Betik AC, Parker L, Kaur G, Richards SM, Premilovac D, Wadley GD, Keske MA
Am J Physiol Endocrinol Metab 2022 Nov 1;323(5):E418-E427. Epub 2022 Jun 20 doi: 10.1152/ajpendo.00109.2022. PMID: 35723226
Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.
Rouault C, Marcelin G, Adriouch S, Rose C, Genser L, Ambrosini M, Bichet JC, Zhang Y, Marquet F, Aron-Wisnewsky J, Poitou C, André S, Dérumeaux G, Guerre-Millo M, Clément K
Diabetologia 2021 Jan;64(1):240-254. Epub 2020 Oct 30 doi: 10.1007/s00125-020-05307-0. PMID: 33125520
The pathophysiology of abdominal adipose tissue depots in health and disease.
Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F
Horm Mol Biol Clin Investig 2014 Jul;19(1):57-74. doi: 10.1515/hmbci-2014-0023. PMID: 25390016
Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance.
Patel P, Abate N
J Obes 2013;2013:489187. Epub 2013 Apr 4 doi: 10.1155/2013/489187. PMID: 23691287Free PMC Article
Adipose tissue heterogeneity: implication of depot differences in adipose tissue for obesity complications.
Lee MJ, Wu Y, Fried SK
Mol Aspects Med 2013 Feb;34(1):1-11. Epub 2012 Oct 13 doi: 10.1016/j.mam.2012.10.001. PMID: 23068073Free PMC Article

Diagnosis

Impaired postprandial adipose tissue microvascular blood flow responses to a mixed-nutrient meal in first-degree relatives of adults with type 2 diabetes.
Roberts-Thomson KM, Hu D, Russell RD, Greenaway T, Betik AC, Parker L, Kaur G, Richards SM, Premilovac D, Wadley GD, Keske MA
Am J Physiol Endocrinol Metab 2022 Nov 1;323(5):E418-E427. Epub 2022 Jun 20 doi: 10.1152/ajpendo.00109.2022. PMID: 35723226
Capsaicin as an anti-obesity drug.
Leung FW
Prog Drug Res 2014;68:171-9. doi: 10.1007/978-3-0348-0828-6_7. PMID: 24941669
Obesity and dyslipidemia in South Asians.
Misra A, Shrivastava U
Nutrients 2013 Jul 16;5(7):2708-33. doi: 10.3390/nu5072708. PMID: 23863826Free PMC Article
Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance.
Patel P, Abate N
J Obes 2013;2013:489187. Epub 2013 Apr 4 doi: 10.1155/2013/489187. PMID: 23691287Free PMC Article
Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy.
Attallah H, Friedlander AL, Hoffman AR
Growth Horm IGF Res 2006 Jul;16 Suppl A:S62-7. Epub 2006 Apr 18 doi: 10.1016/j.ghir.2006.03.004. PMID: 16624603

Therapy

Clinical evaluation of automated segmentation for body composition analysis on abdominal L3 CT slices in polytrauma patients.
Ackermans LLGC, Volmer L, Timmermans QMMA, Brecheisen R, Damink SMWO, Dekker A, Loeffen D, Poeze M, Blokhuis TJ, Wee L, Ten Bosch JA
Injury 2022 Nov;53 Suppl 3:S30-S41. Epub 2022 Jun 2 doi: 10.1016/j.injury.2022.05.004. PMID: 35680433
Senescence-associated β-galactosidase in subcutaneous adipose tissue associates with altered glycaemic status and truncal fat in severe obesity.
Rouault C, Marcelin G, Adriouch S, Rose C, Genser L, Ambrosini M, Bichet JC, Zhang Y, Marquet F, Aron-Wisnewsky J, Poitou C, André S, Dérumeaux G, Guerre-Millo M, Clément K
Diabetologia 2021 Jan;64(1):240-254. Epub 2020 Oct 30 doi: 10.1007/s00125-020-05307-0. PMID: 33125520
Capsaicin as an anti-obesity drug.
Leung FW
Prog Drug Res 2014;68:171-9. doi: 10.1007/978-3-0348-0828-6_7. PMID: 24941669
Associations between breast adipose tissue, body fat distribution and cardiometabolic risk in women: cross-sectional data and weight-loss intervention.
Schautz B, Later W, Heller M, Müller MJ, Bosy-Westphal A
Eur J Clin Nutr 2011 Jul;65(7):784-90. Epub 2011 Mar 23 doi: 10.1038/ejcn.2011.35. PMID: 21427743
Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy.
Attallah H, Friedlander AL, Hoffman AR
Growth Horm IGF Res 2006 Jul;16 Suppl A:S62-7. Epub 2006 Apr 18 doi: 10.1016/j.ghir.2006.03.004. PMID: 16624603

Prognosis

Abdominal adipose tissue components quantification in MRI as a relevant biomarker of metabolic profile.
Bouazizi K, Zarai M, Dietenbeck T, Aron-Wisnewsky J, Clément K, Redheuil A, Kachenoura N
Magn Reson Imaging 2021 Jul;80:14-20. Epub 2021 Apr 17 doi: 10.1016/j.mri.2021.04.002. PMID: 33872732
Capsaicin as an anti-obesity drug.
Leung FW
Prog Drug Res 2014;68:171-9. doi: 10.1007/978-3-0348-0828-6_7. PMID: 24941669
Associations between breast adipose tissue, body fat distribution and cardiometabolic risk in women: cross-sectional data and weight-loss intervention.
Schautz B, Later W, Heller M, Müller MJ, Bosy-Westphal A
Eur J Clin Nutr 2011 Jul;65(7):784-90. Epub 2011 Mar 23 doi: 10.1038/ejcn.2011.35. PMID: 21427743
A brief update of glucocorticoid receptor variants and obesity risk.
Rosmond R, Radulovic V, Holm G
Ann N Y Acad Sci 2006 Nov;1083:153-64. doi: 10.1196/annals.1367.011. PMID: 17148738
Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy.
Attallah H, Friedlander AL, Hoffman AR
Growth Horm IGF Res 2006 Jul;16 Suppl A:S62-7. Epub 2006 Apr 18 doi: 10.1016/j.ghir.2006.03.004. PMID: 16624603

Clinical prediction guides

Abdominal adipose tissue components quantification in MRI as a relevant biomarker of metabolic profile.
Bouazizi K, Zarai M, Dietenbeck T, Aron-Wisnewsky J, Clément K, Redheuil A, Kachenoura N
Magn Reson Imaging 2021 Jul;80:14-20. Epub 2021 Apr 17 doi: 10.1016/j.mri.2021.04.002. PMID: 33872732
The pathophysiology of abdominal adipose tissue depots in health and disease.
Walker GE, Marzullo P, Ricotti R, Bona G, Prodam F
Horm Mol Biol Clin Investig 2014 Jul;19(1):57-74. doi: 10.1515/hmbci-2014-0023. PMID: 25390016
Capsaicin as an anti-obesity drug.
Leung FW
Prog Drug Res 2014;68:171-9. doi: 10.1007/978-3-0348-0828-6_7. PMID: 24941669
A brief update of glucocorticoid receptor variants and obesity risk.
Rosmond R, Radulovic V, Holm G
Ann N Y Acad Sci 2006 Nov;1083:153-64. doi: 10.1196/annals.1367.011. PMID: 17148738
Visceral obesity, impaired glucose tolerance, metabolic syndrome, and growth hormone therapy.
Attallah H, Friedlander AL, Hoffman AR
Growth Horm IGF Res 2006 Jul;16 Suppl A:S62-7. Epub 2006 Apr 18 doi: 10.1016/j.ghir.2006.03.004. PMID: 16624603

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