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Myopia 8(MYP8)

MedGen UID:
332223
Concept ID:
C1836505
Disease or Syndrome
Synonym: MYP8
 
Monarch Initiative: MONDO:0012228
OMIM®: 609257

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. [from OMIM]

Clinical features

From HPO
Myopia
MedGen UID:
44558
Concept ID:
C0027092
Disease or Syndrome
Nearsightedness, also known as myopia, is an eye condition that causes blurry distance vision. People who are nearsighted have more trouble seeing things that are far away (such as when driving) than things that are close up (such as when reading or using a computer). If it is not treated with corrective lenses or surgery, nearsightedness can lead to squinting, eyestrain, headaches, and significant visual impairment.\n\nNearsightedness usually begins in childhood or adolescence. It tends to worsen with age until adulthood, when it may stop getting worse (stabilize). In some people, nearsightedness improves in later adulthood.\n\nFor normal vision, light passes through the clear cornea at the front of the eye and is focused by the lens onto the surface of the retina, which is the lining of the back of the eye that contains light-sensing cells. People who are nearsighted typically have eyeballs that are too long from front to back. As a result, light entering the eye is focused too far forward, in front of the retina instead of on its surface. It is this change that causes distant objects to appear blurry. The longer the eyeball is, the farther forward light rays will be focused and the more severely nearsighted a person will be.\n\nNearsightedness is measured by how powerful a lens must be to correct it. The standard unit of lens power is called a diopter. Negative (minus) powered lenses are used to correct nearsightedness. The more severe a person's nearsightedness, the larger the number of diopters required for correction. In an individual with nearsightedness, one eye may be more nearsighted than the other.\n\nEye doctors often refer to nearsightedness less than -5 or -6 diopters as "common myopia." Nearsightedness of -6 diopters or more is commonly called "high myopia." This distinction is important because high myopia increases a person's risk of developing other eye problems that can lead to permanent vision loss or blindness. These problems include tearing and detachment of the retina, clouding of the lens (cataract), and an eye disease called glaucoma that is usually related to increased pressure within the eye. The risk of these other eye problems increases with the severity of the nearsightedness. The term "pathological myopia" is used to describe cases in which high myopia leads to tissue damage within the eye.

Professional guidelines

PubMed

Martínez-Pérez C, Villa-Collar C, Santodomingo-Rubido J, Wolffsohn JS
J Optom 2024 Jan-Mar;17(1):100496. Epub 2023 Oct 23 doi: 10.1016/j.optom.2023.100496. PMID: 37879183Free PMC Article
Barnett JM, Hubbard GB
Curr Opin Ophthalmol 2021 Sep 1;32(5):475-481. doi: 10.1097/ICU.0000000000000783. PMID: 34231532Free PMC Article

Recent clinical studies

Etiology

Lee SS, Mackey DA
Front Public Health 2022;10:861044. Epub 2022 Apr 27 doi: 10.3389/fpubh.2022.861044. PMID: 35570945Free PMC Article
Ha A, Kim CY, Shim SR, Chang IB, Kim YK
Am J Ophthalmol 2022 Apr;236:107-119. Epub 2021 Oct 11 doi: 10.1016/j.ajo.2021.10.007. PMID: 34648776
Bullimore MA, Ritchey ER, Shah S, Leveziel N, Bourne RRA, Flitcroft DI
Ophthalmology 2021 Nov;128(11):1561-1579. Epub 2021 May 4 doi: 10.1016/j.ophtha.2021.04.032. PMID: 33961969
Wang J, Li Y, Musch DC, Wei N, Qi X, Ding G, Li X, Li J, Song L, Zhang Y, Ning Y, Zeng X, Hua N, Li S, Qian X
JAMA Ophthalmol 2021 Mar 1;139(3):293-300. doi: 10.1001/jamaophthalmol.2020.6239. PMID: 33443542Free PMC Article
Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S
Ophthalmology 2016 May;123(5):1036-42. Epub 2016 Feb 11 doi: 10.1016/j.ophtha.2016.01.006. PMID: 26875007

Diagnosis

Tang J, Liao Y, Yan N, Dereje SB, Wang J, Luo Y, Wang Y, Zhou W, Wang X, Wang W
Am J Ophthalmol 2023 Aug;252:153-163. Epub 2023 Apr 7 doi: 10.1016/j.ajo.2023.03.036. PMID: 37030495
Li SM, Wei S, Atchison DA, Kang MT, Liu L, Li H, Li S, Yang Z, Wang Y, Zhang F, Wang N
Invest Ophthalmol Vis Sci 2022 Jan 3;63(1):8. doi: 10.1167/iovs.63.1.8. PMID: 34989760Free PMC Article
Wang J, Li Y, Musch DC, Wei N, Qi X, Ding G, Li X, Li J, Song L, Zhang Y, Ning Y, Zeng X, Hua N, Li S, Qian X
JAMA Ophthalmol 2021 Mar 1;139(3):293-300. doi: 10.1001/jamaophthalmol.2020.6239. PMID: 33443542Free PMC Article
Gong Q, Janowski M, Luo M, Wei H, Chen B, Yang G, Liu L
JAMA Ophthalmol 2017 Jun 1;135(6):624-630. doi: 10.1001/jamaophthalmol.2017.1091. PMID: 28494063Free PMC Article
Zadnik K, Sinnott LT, Cotter SA, Jones-Jordan LA, Kleinstein RN, Manny RE, Twelker JD, Mutti DO; Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group
JAMA Ophthalmol 2015 Jun;133(6):683-9. doi: 10.1001/jamaophthalmol.2015.0471. PMID: 25837970Free PMC Article

Therapy

Yam JC, Zhang XJ, Zhang Y, Yip BHK, Tang F, Wong ES, Bui CHT, Kam KW, Ng MPH, Ko ST, Yip WWK, Young AL, Tham CC, Chen LJ, Pang CP
JAMA 2023 Feb 14;329(6):472-481. doi: 10.1001/jama.2022.24162. PMID: 36786791Free PMC Article
Ha A, Kim CY, Shim SR, Chang IB, Kim YK
Am J Ophthalmol 2022 Apr;236:107-119. Epub 2021 Oct 11 doi: 10.1016/j.ajo.2021.10.007. PMID: 34648776
Bao J, Yang A, Huang Y, Li X, Pan Y, Ding C, Lim EW, Zheng J, Spiegel DP, Drobe B, Lu F, Chen H
Br J Ophthalmol 2022 Aug;106(8):1171-1176. Epub 2021 Apr 2 doi: 10.1136/bjophthalmol-2020-318367. PMID: 33811039Free PMC Article
Lam CSY, Tang WC, Tse DY, Lee RPK, Chun RKM, Hasegawa K, Qi H, Hatanaka T, To CH
Br J Ophthalmol 2020 Mar;104(3):363-368. Epub 2019 May 29 doi: 10.1136/bjophthalmol-2018-313739. PMID: 31142465Free PMC Article
Yam JC, Jiang Y, Tang SM, Law AKP, Chan JJ, Wong E, Ko ST, Young AL, Tham CC, Chen LJ, Pang CP
Ophthalmology 2019 Jan;126(1):113-124. Epub 2018 Jul 6 doi: 10.1016/j.ophtha.2018.05.029. PMID: 30514630

Prognosis

Lee SS, Lingham G, Sanfilippo PG, Hammond CJ, Saw SM, Guggenheim JA, Yazar S, Mackey DA
JAMA Ophthalmol 2022 Feb 1;140(2):162-169. doi: 10.1001/jamaophthalmol.2021.5067. PMID: 34989764Free PMC Article
Li SM, Wei S, Atchison DA, Kang MT, Liu L, Li H, Li S, Yang Z, Wang Y, Zhang F, Wang N
Invest Ophthalmol Vis Sci 2022 Jan 3;63(1):8. doi: 10.1167/iovs.63.1.8. PMID: 34989760Free PMC Article
Bullimore MA, Ritchey ER, Shah S, Leveziel N, Bourne RRA, Flitcroft DI
Ophthalmology 2021 Nov;128(11):1561-1579. Epub 2021 May 4 doi: 10.1016/j.ophtha.2021.04.032. PMID: 33961969
Wu PC, Chen CT, Lin KK, Sun CC, Kuo CN, Huang HM, Poon YC, Yang ML, Chen CY, Huang JC, Wu PC, Yang IH, Yu HJ, Fang PC, Tsai CL, Chiou ST, Yang YH
Ophthalmology 2018 Aug;125(8):1239-1250. Epub 2018 Jan 19 doi: 10.1016/j.ophtha.2017.12.011. PMID: 29371008
Tideman JWL, Polling JR, Vingerling JR, Jaddoe VWV, Williams C, Guggenheim JA, Klaver CCW
Acta Ophthalmol 2018 May;96(3):301-309. Epub 2017 Dec 19 doi: 10.1111/aos.13603. PMID: 29265742Free PMC Article

Clinical prediction guides

Bullimore MA, Ritchey ER, Shah S, Leveziel N, Bourne RRA, Flitcroft DI
Ophthalmology 2021 Nov;128(11):1561-1579. Epub 2021 May 4 doi: 10.1016/j.ophtha.2021.04.032. PMID: 33961969
Mountjoy E, Davies NM, Plotnikov D, Smith GD, Rodriguez S, Williams CE, Guggenheim JA, Atan D
BMJ 2018 Jun 6;361:k2022. doi: 10.1136/bmj.k2022. PMID: 29875094Free PMC Article
Tideman JWL, Polling JR, Vingerling JR, Jaddoe VWV, Williams C, Guggenheim JA, Klaver CCW
Acta Ophthalmol 2018 May;96(3):301-309. Epub 2017 Dec 19 doi: 10.1111/aos.13603. PMID: 29265742Free PMC Article
Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S
Ophthalmology 2016 May;123(5):1036-42. Epub 2016 Feb 11 doi: 10.1016/j.ophtha.2016.01.006. PMID: 26875007
Zadnik K, Sinnott LT, Cotter SA, Jones-Jordan LA, Kleinstein RN, Manny RE, Twelker JD, Mutti DO; Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group
JAMA Ophthalmol 2015 Jun;133(6):683-9. doi: 10.1001/jamaophthalmol.2015.0471. PMID: 25837970Free PMC Article

Recent systematic reviews

Tang J, Liao Y, Yan N, Dereje SB, Wang J, Luo Y, Wang Y, Zhou W, Wang X, Wang W
Am J Ophthalmol 2023 Aug;252:153-163. Epub 2023 Apr 7 doi: 10.1016/j.ajo.2023.03.036. PMID: 37030495
Agyekum S, Chan PP, Zhang Y, Huo Z, Yip BHK, Ip P, Tham CC, Chen LJ, Zhang XJ, Pang CP, Yam JC
Front Public Health 2023;11:1093836. Epub 2023 Feb 27 doi: 10.3389/fpubh.2023.1093836. PMID: 36923029Free PMC Article
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
Haarman AEG, Enthoven CA, Tideman JWL, Tedja MS, Verhoeven VJM, Klaver CCW
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):49. doi: 10.1167/iovs.61.4.49. PMID: 32347918Free PMC Article
Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, Wong TY, Naduvilath TJ, Resnikoff S
Ophthalmology 2016 May;123(5):1036-42. Epub 2016 Feb 11 doi: 10.1016/j.ophtha.2016.01.006. PMID: 26875007

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