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Cutaneous Angioimmunoblastic T-Cell Lymphoma

MedGen UID:
353573
•Concept ID:
C1707541
•
Neoplastic Process

Definition

An aggressive mature T-cell non Hodgkin lymphoma involving the skin. It is characterized by the presence of a polymorphic cellular infiltrate which contains neoplastic small to medium sized T-lymphocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Angioimmunoblastic T-Cell Lymphoma

Professional guidelines

PubMed

Use of fludarabine in the treatment of mantle cell lymphoma, Waldenström's macroglobulinemia and other uncommon B- and T-cell lymphoid malignancies.
Johnson SA
Hematol J 2004;5 Suppl 1:S50-61. doi: 10.1038/sj.thj.6200391. PMID: 15079153

Recent clinical studies

Etiology

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Angioimmunoblastic T-cell lymphoma and Kaposi sarcoma: A fortuitous collision?
Poullot E, Milowich D, Lemonnier F, Bisig B, Robe C, Pelletier L, Letourneau A, Dupuy A, Sako N, Ketterer N, Carde P, Dartigues P, Delfau-Larue MH, de Leval L, Gaulard P
Histopathology 2024 Feb;84(3):556-564. Epub 2023 Nov 21 doi: 10.1111/his.15083. PMID: 37988271
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part II: Prognosis and management.
Oh Y, Stoll JR, Moskowitz A, Pulitzer M, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1093-1106. Epub 2021 May 1 doi: 10.1016/j.jaad.2021.04.081. PMID: 33945836
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Peripheral T-cell lymphoma: the role of hematopoietic stem cell transplantation.
Gkotzamanidou M, Papadimitriou CA
Crit Rev Oncol Hematol 2014 Feb;89(2):248-61. Epub 2013 Sep 8 doi: 10.1016/j.critrevonc.2013.08.016. PMID: 24075060

Diagnosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Angioimmunoblastic T-cell lymphoma and Kaposi sarcoma: A fortuitous collision?
Poullot E, Milowich D, Lemonnier F, Bisig B, Robe C, Pelletier L, Letourneau A, Dupuy A, Sako N, Ketterer N, Carde P, Dartigues P, Delfau-Larue MH, de Leval L, Gaulard P
Histopathology 2024 Feb;84(3):556-564. Epub 2023 Nov 21 doi: 10.1111/his.15083. PMID: 37988271
Angioimmunoblastic T-cell Lymphoma Mimicking DRESS Syndrome.
Keefe M, Buntinx-Krieg T, Contestable J
Cutis 2022 Mar;109(3):E29-E32. doi: 10.12788/cutis.0498. PMID: 35659145
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part II: Prognosis and management.
Oh Y, Stoll JR, Moskowitz A, Pulitzer M, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1093-1106. Epub 2021 May 1 doi: 10.1016/j.jaad.2021.04.081. PMID: 33945836
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098

Therapy

Allogeneic hematopoietic stem cell transplantation in T-cell lymphoma: a Meta-Analysis.
Singh V, Kim S, Deol A, Uberti JP, Modi D
Leuk Lymphoma 2022 Apr;63(4):855-864. Epub 2021 Dec 5 doi: 10.1080/10428194.2021.1999438. PMID: 34866528
Cutaneous lesions of angioimmunoblastic T-cell lymphoma: Clinical, pathological, and immunophenotypic features.
Oishi N, Sartori-Valinotti JC, Bennani NN, Wada DA, He R, Cappel MA, Feldman AL
J Cutan Pathol 2019 Sep;46(9):637-644. Epub 2019 May 3 doi: 10.1111/cup.13475. PMID: 30980412
T-cell lymphomas, a challenging disease: types, treatments, and future.
Ma H, Abdul-Hay M
Int J Clin Oncol 2017 Feb;22(1):18-51. Epub 2016 Oct 14 doi: 10.1007/s10147-016-1045-2. PMID: 27743148Free PMC Article
Peripheral T-cell lymphoma: the role of hematopoietic stem cell transplantation.
Gkotzamanidou M, Papadimitriou CA
Crit Rev Oncol Hematol 2014 Feb;89(2):248-61. Epub 2013 Sep 8 doi: 10.1016/j.critrevonc.2013.08.016. PMID: 24075060
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697

Prognosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part II: Prognosis and management.
Oh Y, Stoll JR, Moskowitz A, Pulitzer M, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1093-1106. Epub 2021 May 1 doi: 10.1016/j.jaad.2021.04.081. PMID: 33945836
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318
Peripheral T-cell lymphoma: the role of hematopoietic stem cell transplantation.
Gkotzamanidou M, Papadimitriou CA
Crit Rev Oncol Hematol 2014 Feb;89(2):248-61. Epub 2013 Sep 8 doi: 10.1016/j.critrevonc.2013.08.016. PMID: 24075060

Clinical prediction guides

Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study.
Bachy E, Savage KJ, Huang H, Kwong YL, Gritti G, Zhang Q, Liberati AM, Cao J, Yang H, Hao S, Hu J, Zhou K, Petrini M, Russo F, Zhang H, Sang W, Ji J, Ferreri AJM, Damaj GL, Liu H, Zhang W, Ke X, Ghiggi C, Huang S, Li X, Yao H, Paik J, Novotny W, Zhou W, Zhu H, Zinzani PL
Blood Adv 2023 Aug 22;7(16):4435-4447. doi: 10.1182/bloodadvances.2022009575. PMID: 37276067Free PMC Article
Deciphering the spectrum of cutaneous lymphomas expressing TFH markers.
Donzel M, Trecourt A, Balme B, Harou O, Mauduit C, Bachy E, Guesquières H, Fontaine J, Ortonne N, Perier-Muzet M, Dalle S, Traverse-Glehen A
Sci Rep 2023 Apr 20;13(1):6500. doi: 10.1038/s41598-023-33031-3. PMID: 37081015Free PMC Article
Cutaneous Involvement of Angioimmunoblastic T-Cell Lymphoma Masquerading as B-Cell Reactive Lymphoid Hyperplasia.
Pesqué D, Marcantonio O, Vázquez I, Papaleo N, Sánchez-González B, Gallardo F, Colomo L, Pujol RM
Am J Dermatopathol 2022 Apr 1;44(4):e41-e45. doi: 10.1097/DAD.0000000000002110. PMID: 34966050
Cutaneous manifestations of angioimmunoblastic T-cell lymphoma: clinical and pathological characteristics.
Botros N, Cerroni L, Shawwa A, Green PJ, Greer W, Pasternak S, Walsh NM
Am J Dermatopathol 2015 Apr;37(4):274-83. doi: 10.1097/DAD.0000000000000144. PMID: 25794369
Functional classification of peripheral T-cell lymphomas as an approach to improve outcome prediction and therapy selection.
Jones D
Semin Hematol 2010 Apr;47 Suppl 1:S1-4. doi: 10.1053/j.seminhematol.2010.01.013. PMID: 20359579

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