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Thyroid Gland Follicular Adenoma with Bizarre Nuclei

MedGen UID:
354253
•Concept ID:
C1710411
•
Neoplastic Process

Definition

A thyroid gland adenoma containing follicular cells with large hyperchromatic nuclei. The clinical course is benign. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Adenoma with Bizarre Nuclei

Professional guidelines

PubMed

Cytologic findings in thyroid nodules after 131I treatment of hyperthyroidism.
Granter SR, Cibas ES
Am J Clin Pathol 1997 Jan;107(1):20-5. doi: 10.1093/ajcp/107.1.20. PMID: 8980362

Recent clinical studies

Etiology

Can TP53-mutant follicular adenoma be a precursor of anaplastic thyroid carcinoma?
Nikitski AV, Nikiforova MN, Yip L, Karslioglu-French E, Carty SE, Nikiforov YE
Endocr Relat Cancer 2021 Aug 6;28(9):621-630. doi: 10.1530/ERC-21-0095. PMID: 34264855
Histological characteristics of lung adenocarcinoma with uncommon actionable alterations: special emphasis on MET exon 14 skipping alterations.
Hayashi T, Kohsaka S, Takamochi K, Kishikawa S, Ikarashi D, Sano K, Hara K, Onagi H, Suehara Y, Takahashi F, Saito T, Nakatsura T, Kitano S, Suzuki K, Yao T
Histopathology 2021 Jun;78(7):987-999. Epub 2021 Mar 11 doi: 10.1111/his.14311. PMID: 33249657
Anomalous papillary carcinoma of the thyroid.
Johannessen JV, Sobrinões M, Lindmo T, Tangen KO, Kaalhus O, Brennhovd IO
Cancer 1983 Apr 15;51(8):1462-7. doi: 10.1002/1097-0142(19830415)51:8<1462::aid-cncr2820510820>3.0.co;2-u. PMID: 6825055

Diagnosis

Coexistence of atypical adenoma, adenoma with bizarre nuclei and follicular variant of papillary carcinoma of the thyroid.
Pusiol T, Zorzi MG, Morichetti D
Indian J Pathol Microbiol 2013 Oct-Dec;56(4):399-401. doi: 10.4103/0377-4929.125342. PMID: 24441230
Fine needle aspiration cytology of medullary carcinoma of the thyroid with a focus on rare variants: a review of 78 cases.
Kaushal S, Iyer VK, Mathur SR, Ray R
Cytopathology 2011 Apr;22(2):95-105. Epub 2010 May 30 doi: 10.1111/j.1365-2303.2010.00747.x. PMID: 20518799
Thyroid adenomatous nodule with bizarre nuclei: a case report and mutation analysis of the p53 gene.
Sato K, Shimode Y, Hirokawa M, Ueda Y, Katsuda S
Pathol Res Pract 2008;204(3):191-5. Epub 2007 Nov 26 doi: 10.1016/j.prp.2007.10.003. PMID: 18037575
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the thyroid. A case report.
Vázquez Ramírez F, Otal Salaverri C, Argueta Manzano O, Galera Ruíz H, González-Cámpora R
Acta Cytol 2000 Mar-Apr;44(2):259-64. doi: 10.1159/000326372. PMID: 10740618

Therapy

Cytologic findings in thyroid nodules after 131I treatment of hyperthyroidism.
Granter SR, Cibas ES
Am J Clin Pathol 1997 Jan;107(1):20-5. doi: 10.1093/ajcp/107.1.20. PMID: 8980362

Prognosis

Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the thyroid. A case report.
Vázquez Ramírez F, Otal Salaverri C, Argueta Manzano O, Galera Ruíz H, González-Cámpora R
Acta Cytol 2000 Mar-Apr;44(2):259-64. doi: 10.1159/000326372. PMID: 10740618
Anomalous papillary carcinoma of the thyroid.
Johannessen JV, Sobrinões M, Lindmo T, Tangen KO, Kaalhus O, Brennhovd IO
Cancer 1983 Apr 15;51(8):1462-7. doi: 10.1002/1097-0142(19830415)51:8<1462::aid-cncr2820510820>3.0.co;2-u. PMID: 6825055

Clinical prediction guides

Can TP53-mutant follicular adenoma be a precursor of anaplastic thyroid carcinoma?
Nikitski AV, Nikiforova MN, Yip L, Karslioglu-French E, Carty SE, Nikiforov YE
Endocr Relat Cancer 2021 Aug 6;28(9):621-630. doi: 10.1530/ERC-21-0095. PMID: 34264855
Thyroid adenomatous nodule with bizarre nuclei: a case report and mutation analysis of the p53 gene.
Sato K, Shimode Y, Hirokawa M, Ueda Y, Katsuda S
Pathol Res Pract 2008;204(3):191-5. Epub 2007 Nov 26 doi: 10.1016/j.prp.2007.10.003. PMID: 18037575
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the thyroid. A case report.
Vázquez Ramírez F, Otal Salaverri C, Argueta Manzano O, Galera Ruíz H, González-Cámpora R
Acta Cytol 2000 Mar-Apr;44(2):259-64. doi: 10.1159/000326372. PMID: 10740618
Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland.
Gaal JM, Horvath E, Kovacs K
Cancer 1975 May;35(5):1273-9. doi: 10.1002/1097-0142(197505)35:5<1273::aid-cncr2820350502>3.0.co;2-3. PMID: 1122478

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