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DNA Breaks

MedGen UID:: 354581
•Concept ID:: C1721104
•: Molecular Function

Synonyms:

Break, DNA; Breaks, DNA; DNA Break

Definition

Interruptions in the sugar-phosphate backbone of DNA. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDNA Breaks

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Pathogeneses
    - Pathologic Mutagenesis
      - DNA damage
        DNA Breaks
        Chromosome breakage
        Chromosomal breakage induced by crosslinking agents
        Chromosomal breakage induced by ionizing radiation
        Folate-dependent fragile site at Xq28
        Large-Scale State Transition
        DNA Double Strand Break
        DNA Single Strand Break

Professional guidelines

PubMed

Targeting DNA repair for cancer treatment: Lessons from PARP inhibitor trials.

Nambiar DK, Mishra D, Singh RP
Oncol Res 2023;31(4):405-421. Epub 2023 Jun 27 doi: 10.32604/or.2023.028310. PMID: 37415740 Free PMC Article

Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.

Reilly NM, Yard BD, Pittman DL
Methods Mol Biol 2019;1999:3-29. doi: 10.1007/978-1-4939-9500-4_1. PMID: 31127567

Genetic aberrations in paediatric acute leukaemias and implications for management of patients.

Szczepański T, Harrison CJ, van Dongen JJ
Lancet Oncol 2010 Sep;11(9):880-9. Epub 2010 May 7 doi: 10.1016/S1470-2045(09)70369-9. PMID: 20435517

See all (43)

Recent clinical studies

Etiology

Inheritance of paternal DNA damage by histone-mediated repair restriction.

Wang S, Meyer DH, Schumacher B
Nature 2023 Jan;613(7943):365-374. Epub 2022 Dec 21 doi: 10.1038/s41586-022-05544-w. PMID: 36544019 Free PMC Article

Repair pathway choice for double-strand breaks.

Xu Y, Xu D
Essays Biochem 2020 Oct 26;64(5):765-777. doi: 10.1042/EBC20200007. PMID: 32648897

Epidemiology of Breast Cancer in Women.

Coughlin SS
Adv Exp Med Biol 2019;1152:9-29. doi: 10.1007/978-3-030-20301-6_2. PMID: 31456177

DNA topoisomerase-targeting chemotherapeutics: what's new?

Cuya SM, Bjornsti MA, van Waardenburg RCAM
Cancer Chemother Pharmacol 2017 Jul;80(1):1-14. Epub 2017 May 20 doi: 10.1007/s00280-017-3334-5. PMID: 28528358 Free PMC Article

The RAG recombinase: Beyond breaking.

Lescale C, Deriano L
Mech Ageing Dev 2017 Jul;165(Pt A):3-9. Epub 2016 Nov 15 doi: 10.1016/j.mad.2016.11.003. PMID: 27863852

See all (1252)

Diagnosis

Exploiting replication gaps for cancer therapy.

Cong K, Cantor SB
Mol Cell 2022 Jul 7;82(13):2363-2369. Epub 2022 May 13 doi: 10.1016/j.molcel.2022.04.023. PMID: 35568026 Free PMC Article

END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells.

Wong N, John S, Nussenzweig A, Canela A
Methods Mol Biol 2021;2153:9-31. doi: 10.1007/978-1-0716-0644-5_2. PMID: 32840769

Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Chang HHY, Pannunzio NR, Adachi N, Lieber MR
Nat Rev Mol Cell Biol 2017 Aug;18(8):495-506. Epub 2017 May 17 doi: 10.1038/nrm.2017.48. PMID: 28512351 Free PMC Article

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Lieber MR
Annu Rev Biochem 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131. PMID: 20192759 Free PMC Article

The comet assay for DNA damage and repair: principles, applications, and limitations.

Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294

See all (1482)

Therapy

Exploiting replication gaps for cancer therapy.

Cong K, Cantor SB
Mol Cell 2022 Jul 7;82(13):2363-2369. Epub 2022 May 13 doi: 10.1016/j.molcel.2022.04.023. PMID: 35568026 Free PMC Article

Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?

Mirzayans R, Murray D
Int J Mol Sci 2020 Nov 29;21(23) doi: 10.3390/ijms21239090. PMID: 33260475 Free PMC Article

Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy.

Goldenberg DM, Sharkey RM
Expert Opin Biol Ther 2020 Aug;20(8):871-885. Epub 2020 May 12 doi: 10.1080/14712598.2020.1757067. PMID: 32301634

Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan.

Goldenberg DM, Sharkey RM
MAbs 2019 Aug/Sep;11(6):987-995. Epub 2019 Jul 18 doi: 10.1080/19420862.2019.1632115. PMID: 31208270 Free PMC Article

Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers.

Cardillo TM, Govindan SV, Sharkey RM, Trisal P, Arrojo R, Liu D, Rossi EA, Chang CH, Goldenberg DM
Bioconjug Chem 2015 May 20;26(5):919-31. Epub 2015 May 8 doi: 10.1021/acs.bioconjchem.5b00223. PMID: 25915780

See all (1193)

Prognosis

Chromothripsis in hematologic malignancies.

Lagunas-Rangel FA
Exp Hematol 2024 Apr;132:104172. Epub 2024 Feb 1 doi: 10.1016/j.exphem.2024.104172. PMID: 38309572

USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.

Chen Y, Zhao Y, Yang X, Ren X, Huang S, Gong S, Tan X, Li J, He S, Li Y, Hong X, Li Q, Ding C, Fang X, Ma J, Liu N
Nat Commun 2022 Jan 25;13(1):501. doi: 10.1038/s41467-022-28158-2. PMID: 35079021 Free PMC Article

The Impact of Single- and Double-Strand DNA Breaks in Human Spermatozoa on Assisted Reproduction.

Agarwal A, Barbăroșie C, Ambar R, Finelli R
Int J Mol Sci 2020 May 29;21(11) doi: 10.3390/ijms21113882. PMID: 32485940 Free PMC Article

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.

Abkevich V, Timms KM, Hennessy BT, Potter J, Carey MS, Meyer LA, Smith-McCune K, Broaddus R, Lu KH, Chen J, Tran TV, Williams D, Iliev D, Jammulapati S, FitzGerald LM, Krivak T, DeLoia JA, Gutin A, Mills GB, Lanchbury JS
Br J Cancer 2012 Nov 6;107(10):1776-82. Epub 2012 Oct 9 doi: 10.1038/bjc.2012.451. PMID: 23047548 Free PMC Article

Sperm DNA fragmentation.

Shafik A, Shafik AA, Shafik I, El Sibai O
Arch Androl 2006 May-Jun;52(3):197-208. doi: 10.1080/01485010500503561. PMID: 16574602

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Clinical prediction guides

Sperm DNA Fragmentation.

Karavolos S
Semin Reprod Med 2021 Nov;39(5-06):194-199. Epub 2021 Oct 18 doi: 10.1055/s-0041-1736261. PMID: 34662912

Chromatin mobility and relocation in DNA repair.

Lamm N, Rogers S, Cesare AJ
Trends Cell Biol 2021 Oct;31(10):843-855. Epub 2021 Jun 26 doi: 10.1016/j.tcb.2021.06.002. PMID: 34183232

Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?

Mirzayans R, Murray D
Int J Mol Sci 2020 Nov 29;21(23) doi: 10.3390/ijms21239090. PMID: 33260475 Free PMC Article

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.

The comet assay for DNA damage and repair: principles, applications, and limitations.

Collins AR
Mol Biotechnol 2004 Mar;26(3):249-61. doi: 10.1385/MB:26:3:249. PMID: 15004294

See all (1975)

Recent systematic reviews

Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review).

Rivero Belenchón I, Congregado Ruiz CB, Saez C, Osman García I, Medina López RA
Int J Mol Sci 2023 Aug 19;24(16) doi: 10.3390/ijms241612978. PMID: 37629155 Free PMC Article

Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering.

Ghorbani A, Quinlan EM, Larijani M
Front Immunol 2021;12:642343. Epub 2021 May 31 doi: 10.3389/fimmu.2021.642343. PMID: 34135887 Free PMC Article

Sperm DNA Fragmentation: Consequences for Reproduction.

Simon L, Emery B, Carrell DT
Adv Exp Med Biol 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6. PMID: 31301048

Coffee and caffeine intake and male infertility: a systematic review.

Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F
Nutr J 2017 Jun 24;16(1):37. doi: 10.1186/s12937-017-0257-2. PMID: 28646871 Free PMC Article

Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis.

Jacobs DI, Bracken MB
BMC Med Genet 2012 Oct 26;13:97. doi: 10.1186/1471-2350-13-97. PMID: 23101479 Free PMC Article

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