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Chronic disseminated intravascular coagulation

MedGen UID:
354681
•Concept ID:
C1862184
•
Disease or Syndrome; Finding
Synonym: Chronic consumption coagulopathy
 
HPO: HP:0005520

Definition

A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic disseminated intravascular coagulation

Conditions with this feature

Blue rubber bleb nevus
MedGen UID:
83401
•Concept ID:
C0346072
•
Congenital Abnormality
A rare vascular malformation disorder with cutaneous and visceral lesions frequently associated with serious, potentially fatal bleeding and anemia.
See: Condition Record
Blue rubber bleb nevus

Professional guidelines

PubMed

Regression of kaposiform lymphangiomatosis and chronic disseminated intravascular coagulation after inhaled budesonide-formoterol treatment.
Imamura M, Shin C, Ozeki M, Matsuoka K, Saitoh A, Imai C
Pediatr Blood Cancer 2024 Apr;71(4):e30907. Epub 2024 Jan 31 doi: 10.1002/pbc.30907. PMID: 38296836
Management of Thrombohemorrhagic Syndromes (THS) in hematologic malignancies.
Falanga A, Rickles FR
Hematology Am Soc Hematol Educ Program 2007:165-71. doi: 10.1182/asheducation-2007.1.165. PMID: 18024625
Complications and failure of anticoagulation therapy in the treatment of venous thromboembolism in patients with disseminated malignancy.
Chan A, Woodruff RK
Aust N Z J Med 1992 Apr;22(2):119-22. doi: 10.1111/j.1445-5994.1992.tb02789.x. PMID: 1530532

Recent clinical studies

Etiology

Preoperative disseminated intravascular coagulation complicated by thoracic aortic aneurysm treated using recombinant human soluble thrombomodulin: A case report.
Tanigawa Y, Yamada Y, Nakamura K, Yamashita T, Nakagawachi A, Sakaguchi Y
Medicine (Baltimore) 2021 Mar 5;100(9):e25044. doi: 10.1097/MD.0000000000025044. PMID: 33655983Free PMC Article
Apixaban for the Treatment of Chronic Disseminated Intravascular Coagulation: A Report of Two Cases.
Janjetovic S, Holstein K, Dicke C, Bokemeyer C, Langer F
Hamostaseologie 2019 Aug;39(3):294-297. Epub 2018 Nov 19 doi: 10.1055/s-0038-1675386. PMID: 30453340
Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients.
Zhang Y, Li C, Shen M, Liu B, Zeng X, Shen T
Front Med 2017 Mar;11(1):62-67. Epub 2017 Mar 2 doi: 10.1007/s11684-017-0498-7. PMID: 28233246
Coagulopathy in liver diseases.
Pluta A, Gutkowski K, Hartleb M
Adv Med Sci 2010;55(1):16-21. doi: 10.2478/v10039-010-0018-3. PMID: 20513645
Pharmacology of selective thrombin inhibitors.
Markwardt F
Nouv Rev Fr Hematol (1978) 1988;30(3):161-5. PMID: 3047669

Diagnosis

Chronic disseminated intravascular coagulation in a patient with Takayasu arteritis.
Yilmaz N, Goksoy HS, Sever IH, Yavuz S
Mod Rheumatol Case Rep 2023 Jan 3;7(1):138-141. doi: 10.1093/mrcr/rxac078. PMID: 36300923
Preoperative disseminated intravascular coagulation complicated by thoracic aortic aneurysm treated using recombinant human soluble thrombomodulin: A case report.
Tanigawa Y, Yamada Y, Nakamura K, Yamashita T, Nakagawachi A, Sakaguchi Y
Medicine (Baltimore) 2021 Mar 5;100(9):e25044. doi: 10.1097/MD.0000000000025044. PMID: 33655983Free PMC Article
Thoracic endovascular repair for disseminated intravascular coagulation associated with chronic type B aortic dissection.
Yamamoto J, Hiraoka A, Yoshitaka H
Vascular 2020 Dec;28(6):705-707. Epub 2020 Jun 17 doi: 10.1177/1708538120934575. PMID: 33045945
Apixaban for the Treatment of Chronic Disseminated Intravascular Coagulation: A Report of Two Cases.
Janjetovic S, Holstein K, Dicke C, Bokemeyer C, Langer F
Hamostaseologie 2019 Aug;39(3):294-297. Epub 2018 Nov 19 doi: 10.1055/s-0038-1675386. PMID: 30453340
Splenomegaly and chronic disseminated intravascular coagulation in Osler-Weber-Rendu disease: a case report.
Notoya A, Bohgaki T, Mukai M, Kohno M, Sato H, Sawada K
Am J Hematol 2000 Dec;65(4):315-8. doi: 10.1002/1096-8652(200012)65:4<315::aid-ajh12>3.0.co;2-8. PMID: 11074562

Therapy

Large intraosseous chronic expanding hematoma after total hip arthroplasty presenting with chronic disseminated intravascular coagulation: a case report and literature review.
Yamamuro Y, Kabata T, Takeuchi A, Kajino Y, Inoue D, Ohmori T, Yoshitani J, Ueno T, Ueoka K, Taninaka A, Kataoka T, Saiki Y, Tsuchiya H
BMC Musculoskelet Disord 2022 Jun 24;23(1):609. doi: 10.1186/s12891-022-05571-8. PMID: 35739487Free PMC Article
Preoperative disseminated intravascular coagulation complicated by thoracic aortic aneurysm treated using recombinant human soluble thrombomodulin: A case report.
Tanigawa Y, Yamada Y, Nakamura K, Yamashita T, Nakagawachi A, Sakaguchi Y
Medicine (Baltimore) 2021 Mar 5;100(9):e25044. doi: 10.1097/MD.0000000000025044. PMID: 33655983Free PMC Article
Apixaban for the Treatment of Chronic Disseminated Intravascular Coagulation: A Report of Two Cases.
Janjetovic S, Holstein K, Dicke C, Bokemeyer C, Langer F
Hamostaseologie 2019 Aug;39(3):294-297. Epub 2018 Nov 19 doi: 10.1055/s-0038-1675386. PMID: 30453340
Recurrent Early Coronary Stent Thrombosis under Chronic Disseminated Intravascular Coagulation.
Oba Y, Hoshide S, Mitama T, Shinohara H, Komori T, Kabutoya T, Imai Y, Ogata N, Kario K
Int Heart J 2017 Dec 12;58(6):988-992. Epub 2017 Nov 22 doi: 10.1536/ihj.17-010. PMID: 29162782
Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients.
Zhang Y, Li C, Shen M, Liu B, Zeng X, Shen T
Front Med 2017 Mar;11(1):62-67. Epub 2017 Mar 2 doi: 10.1007/s11684-017-0498-7. PMID: 28233246

Prognosis

Recurrent Early Coronary Stent Thrombosis under Chronic Disseminated Intravascular Coagulation.
Oba Y, Hoshide S, Mitama T, Shinohara H, Komori T, Kabutoya T, Imai Y, Ogata N, Kario K
Int Heart J 2017 Dec 12;58(6):988-992. Epub 2017 Nov 22 doi: 10.1536/ihj.17-010. PMID: 29162782
Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients.
Zhang Y, Li C, Shen M, Liu B, Zeng X, Shen T
Front Med 2017 Mar;11(1):62-67. Epub 2017 Mar 2 doi: 10.1007/s11684-017-0498-7. PMID: 28233246
Soluble thrombomodulin, a possible predictor of thrombotic crisis in thrombotic disease.
Fujita H
J Dermatol 2000 Sep;27(9):573-5. doi: 10.1111/j.1346-8138.2000.tb02231.x. PMID: 11052232
An adult case of lymphangiomatosis of the mediastinum, pulmonary interstitium and retroperitoneum complicated by chronic disseminated intravascular coagulation.
Takahashi K, Takahashi H, Maeda K, Homma S, Uekusa T, Dambara T, Kira S
Eur Respir J 1995 Oct;8(10):1799-802. doi: 10.1183/09031936.95.08101799. PMID: 8586141
Primary antiphospholipid syndrome and chronic disseminated intravascular coagulation: the differences and the similarities.
Lee HC, Groothuis JS, Schlueter WJ, Laya MB
Nebr Med J 1992 Jan;77(1):7-12. PMID: 1549196

Clinical prediction guides

Large intraosseous chronic expanding hematoma after total hip arthroplasty presenting with chronic disseminated intravascular coagulation: a case report and literature review.
Yamamuro Y, Kabata T, Takeuchi A, Kajino Y, Inoue D, Ohmori T, Yoshitani J, Ueno T, Ueoka K, Taninaka A, Kataoka T, Saiki Y, Tsuchiya H
BMC Musculoskelet Disord 2022 Jun 24;23(1):609. doi: 10.1186/s12891-022-05571-8. PMID: 35739487Free PMC Article
Preoperative disseminated intravascular coagulation complicated by thoracic aortic aneurysm treated using recombinant human soluble thrombomodulin: A case report.
Tanigawa Y, Yamada Y, Nakamura K, Yamashita T, Nakagawachi A, Sakaguchi Y
Medicine (Baltimore) 2021 Mar 5;100(9):e25044. doi: 10.1097/MD.0000000000025044. PMID: 33655983Free PMC Article
Intraductal papillary neoplasm of intrahepatic bile ducts complicated by chronic disseminated intravascular coagulation and thrombosis: A case report.
Xiao M, Sun A, Yu F, Xiao Y, Li L, Shen D, Xiang C, Dong J
Medicine (Baltimore) 2021 Feb 5;100(5):e24454. doi: 10.1097/MD.0000000000024454. PMID: 33592896Free PMC Article
Splenomegaly and chronic disseminated intravascular coagulation in Osler-Weber-Rendu disease: a case report.
Notoya A, Bohgaki T, Mukai M, Kohno M, Sato H, Sawada K
Am J Hematol 2000 Dec;65(4):315-8. doi: 10.1002/1096-8652(200012)65:4<315::aid-ajh12>3.0.co;2-8. PMID: 11074562
Case report: chronic disseminated intravascular coagulation due to occult carcinoma.
Mant MJ, Fisk RL, Amy RW
Am J Med Sci 1977 Jul-Aug;274(1):69-74. doi: 10.1097/00000441-197707000-00010. PMID: 900158

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