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Trigeminal anesthesia

MedGen UID:: 355635
•Concept ID:: C1866127
•: Finding

Synonym:	Trigeminal anaesthesia

HPO:	HP:0031912

Definition

Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTrigeminal anesthesia

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the nervous system
    - Abnormal nervous system physiology
      - Abnormal cranial nerve physiology
        Abnormal fifth cranial nerve physiology
        Trigeminal anesthesia

Conditions with this feature

Gomez Lopez Hernandez syndrome

MedGen UID:: 163201
•Concept ID:: C0795959
•: Disease or Syndrome

Gomez-Lopez-Hernandez syndrome (GLHS), also known as cerebellotrigeminal dermal dysplasia, is a rare neurocutaneous syndrome classically characterized by the triad of rhombencephalosynapsis, trigeminal anesthesia, often giving rise to corneal opacities, and bilateral parietal or parietooccipital alopecia. However, trigeminal anesthesia is an inconsistent finding (summary by Sukhudyan et al., 2010).

See: Condition Record

Gomez Lopez Hernandez syndrome

Professional guidelines

PubMed

Gómez-López-Hernández syndrome: reappraisal of the diagnostic criteria.

Sukhudyan B, Jaladyan V, Melikyan G, Schlump JU, Boltshauser E, Poretti A
Eur J Pediatr 2010 Dec;169(12):1523-8. Epub 2010 Jul 23 doi: 10.1007/s00431-010-1259-7. PMID: 20652311

Surgical management of trigeminal schwannomas.

Ramina R, Mattei TA, Sória MG, da Silva EB Jr, Leal AG, Neto MC, Fernandes YB
Neurosurg Focus 2008;25(6):E6; discussion E6. doi: 10.3171/FOC.2008.25.12.E6. PMID: 19035703

See all (2)

Recent clinical studies

Etiology

Seeing through the evidence for corneal neurotization.

Jowett N, Pineda R 2nd
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):252-258. doi: 10.1097/MOO.0000000000000731. PMID: 34074877

Trigeminal nerve deficit in large and compressive acoustic neuromas and its correlation with MRI findings.

Karkas A, Lamblin E, Meyer M, Gay E, Ternier J, Schmerber S
Otolaryngol Head Neck Surg 2014 Oct;151(4):675-80. Epub 2014 Aug 1 doi: 10.1177/0194599814545440. PMID: 25085321

Surgical management of trigeminal schwannomas.

Ramina R, Mattei TA, Sória MG, da Silva EB Jr, Leal AG, Neto MC, Fernandes YB
Neurosurg Focus 2008;25(6):E6; discussion E6. doi: 10.3171/FOC.2008.25.12.E6. PMID: 19035703

Self-induced nasal ulceration.

Tollefson TT, Kriet JD, Wang TD, Cook TA
Arch Facial Plast Surg 2004 May-Jun;6(3):162-6. doi: 10.1001/archfaci.6.3.162. PMID: 15148123

Congenital trigeminal anesthesia in two siblings and their long-term follow-up.

Wong VA, Cline RA, Dubord PJ, Rees M
Am J Ophthalmol 2000 Jan;129(1):96-8. doi: 10.1016/s0002-9394(99)00290-1. PMID: 10653422

See all (7)

Diagnosis

Prenatal Diagnosis of Gómez-López-Hernández Syndrome.

Pomar L, Rieder W, Dubruc E, Giuliano F, Atallah I, Lebon S, Vial Y
Fetal Diagn Ther 2023;50(2):92-97. Epub 2023 Apr 14 doi: 10.1159/000530643. PMID: 37062278

Clinical and molecular evaluation of 13 Brazilian patients with Gomez-López-Hernández syndrome.

Perrone E, Perez ABA, D'Almeida V, de Mello CB, Jacobina MAA, Loureiro RM, Burlin S, Migliavacca M, do Amaral Virmond L, Graziadio C, Pedroso JL, Mendes EL, Gomy I, de Macena Sobreira NL
Am J Med Genet A 2021 Apr;185(4):1047-1058. Epub 2020 Dec 31 doi: 10.1002/ajmg.a.62059. PMID: 33381921

Trigeminal Trophic Syndrome-A Unique Clinical Presentation of a Rare Condition.

Bradburn KH, Elston D, Murphey AW, Patel KG
Ear Nose Throat J 2019 Dec;98(10):606-608. Epub 2019 May 23 doi: 10.1177/0145561319850818. PMID: 31119987

Self-induced nasal ulceration.

Tollefson TT, Kriet JD, Wang TD, Cook TA
Arch Facial Plast Surg 2004 May-Jun;6(3):162-6. doi: 10.1001/archfaci.6.3.162. PMID: 15148123

Congenital trigeminal anesthesia in two siblings and their long-term follow-up.

Wong VA, Cline RA, Dubord PJ, Rees M
Am J Ophthalmol 2000 Jan;129(1):96-8. doi: 10.1016/s0002-9394(99)00290-1. PMID: 10653422

See all (19)

Therapy

Seeing through the evidence for corneal neurotization.

Jowett N, Pineda R 2nd
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):252-258. doi: 10.1097/MOO.0000000000000731. PMID: 34074877

Gomez-López-Hernández syndrome: A case report with clinical and molecular evaluation and literature review.

Perrone E, D'Almeida V, de Macena Sobreira NL, de Mello CB, de Oliveira AC, Burlin S, Soares MFF, Cernach MCSP, Alvarez Perez AB
Am J Med Genet A 2020 Jul;182(7):1761-1766. Epub 2020 Apr 17 doi: 10.1002/ajmg.a.61594. PMID: 32302043 Free PMC Article

Facial Sensory Restoration After Trigeminal Sensory Rhizotomy by Collateral Sprouting From the Occipital Nerves.

Freeman L, Wu OC, Sweet J, Cohen M, Smith GA, Miller JP
Neurosurgery 2020 May 1;86(5):E436-E441. doi: 10.1093/neuros/nyz306. PMID: 31432075

Chronic dysphagia and trigeminal anesthesia after trichloroethylene exposure.

Lawrence WH, Partyka EK
Ann Intern Med 1981 Dec;95(6):710. doi: 10.7326/0003-4819-95-6-710. PMID: 7305154

See all (4)

Prognosis

Adenoid Cystic Carcinoma of the Maxillary Sinus with Isolated Trigeminal Anesthesia.

Bollinger SS, DeSautel MG, Spanos WC, Tjarks BJ
S D Med 2018 Jul;71(7):294-298. PMID: 30005538

Trigeminal nerve deficit in large and compressive acoustic neuromas and its correlation with MRI findings.

Karkas A, Lamblin E, Meyer M, Gay E, Ternier J, Schmerber S
Otolaryngol Head Neck Surg 2014 Oct;151(4):675-80. Epub 2014 Aug 1 doi: 10.1177/0194599814545440. PMID: 25085321

Surgical management of trigeminal schwannomas.

Ramina R, Mattei TA, Sória MG, da Silva EB Jr, Leal AG, Neto MC, Fernandes YB
Neurosurg Focus 2008;25(6):E6; discussion E6. doi: 10.3171/FOC.2008.25.12.E6. PMID: 19035703

Gomez-Lopez-Hernandez syndrome: expansion of the phenotype.

Brocks D, Irons M, Sadeghi-Najad A, McCauley R, Wheeler P
Am J Med Genet 2000 Oct 23;94(5):405-8. doi: 10.1002/1096-8628(20001023)94:5<405::aid-ajmg12>3.0.co;2-8. PMID: 11050627

Congenital trigeminal anesthesia in two siblings and their long-term follow-up.

Wong VA, Cline RA, Dubord PJ, Rees M
Am J Ophthalmol 2000 Jan;129(1):96-8. doi: 10.1016/s0002-9394(99)00290-1. PMID: 10653422

See all (5)

Clinical prediction guides

Facial Sensory Restoration After Trigeminal Sensory Rhizotomy by Collateral Sprouting From the Occipital Nerves.

Freeman L, Wu OC, Sweet J, Cohen M, Smith GA, Miller JP
Neurosurgery 2020 May 1;86(5):E436-E441. doi: 10.1093/neuros/nyz306. PMID: 31432075

Gómez-López-Hernández syndrome in a Japanese patient: a case report.

Kobayashi Y, Kawashima H, Magara S, Akasaka N, Tohyama J
Brain Dev 2015 Mar;37(3):356-8. Epub 2014 May 21 doi: 10.1016/j.braindev.2014.05.002. PMID: 24856766

Gómez-López-Hernández syndrome: reappraisal of the diagnostic criteria.

Sukhudyan B, Jaladyan V, Melikyan G, Schlump JU, Boltshauser E, Poretti A
Eur J Pediatr 2010 Dec;169(12):1523-8. Epub 2010 Jul 23 doi: 10.1007/s00431-010-1259-7. PMID: 20652311

Surgical management of trigeminal schwannomas.

Ramina R, Mattei TA, Sória MG, da Silva EB Jr, Leal AG, Neto MC, Fernandes YB
Neurosurg Focus 2008;25(6):E6; discussion E6. doi: 10.3171/FOC.2008.25.12.E6. PMID: 19035703

See all (4)

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Trigeminal anesthesia

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Clinical resources

Practice guidelines

Consumer resources

Reviews

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