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Myopia 10(MYP10)

MedGen UID:
373104
Concept ID:
C1836503
Disease or Syndrome
Synonym: MYP10
 
Monarch Initiative: MONDO:0012230
OMIM®: 609259

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. [from OMIM]

Clinical features

From HPO
Myopia
MedGen UID:
44558
Concept ID:
C0027092
Disease or Syndrome
Nearsightedness, also known as myopia, is an eye condition that causes blurry distance vision. People who are nearsighted have more trouble seeing things that are far away (such as when driving) than things that are close up (such as when reading or using a computer). If it is not treated with corrective lenses or surgery, nearsightedness can lead to squinting, eyestrain, headaches, and significant visual impairment.\n\nNearsightedness usually begins in childhood or adolescence. It tends to worsen with age until adulthood, when it may stop getting worse (stabilize). In some people, nearsightedness improves in later adulthood.\n\nFor normal vision, light passes through the clear cornea at the front of the eye and is focused by the lens onto the surface of the retina, which is the lining of the back of the eye that contains light-sensing cells. People who are nearsighted typically have eyeballs that are too long from front to back. As a result, light entering the eye is focused too far forward, in front of the retina instead of on its surface. It is this change that causes distant objects to appear blurry. The longer the eyeball is, the farther forward light rays will be focused and the more severely nearsighted a person will be.\n\nNearsightedness is measured by how powerful a lens must be to correct it. The standard unit of lens power is called a diopter. Negative (minus) powered lenses are used to correct nearsightedness. The more severe a person's nearsightedness, the larger the number of diopters required for correction. In an individual with nearsightedness, one eye may be more nearsighted than the other.\n\nEye doctors often refer to nearsightedness less than -5 or -6 diopters as "common myopia." Nearsightedness of -6 diopters or more is commonly called "high myopia." This distinction is important because high myopia increases a person's risk of developing other eye problems that can lead to permanent vision loss or blindness. These problems include tearing and detachment of the retina, clouding of the lens (cataract), and an eye disease called glaucoma that is usually related to increased pressure within the eye. The risk of these other eye problems increases with the severity of the nearsightedness. The term "pathological myopia" is used to describe cases in which high myopia leads to tissue damage within the eye.

Recent clinical studies

Etiology

Palmer E, Stepien KM, Campbell C, Barton S, Iosifidis C, Ghosh A, Broomfield A, Woodall A, Wilcox G, Sergouniotis PI, Black GC
Orphanet J Rare Dis 2023 Sep 4;18(1):265. doi: 10.1186/s13023-023-02840-0. PMID: 37667371Free PMC Article
Demir P, Baskaran K, Theagarayan B, Gierow P, Sankaridurg P, Macedo AF
Clin Exp Optom 2021 Jul;104(5):595-601. Epub 2021 Mar 2 doi: 10.1080/08164622.2021.1878833. PMID: 33689658
Lee JTL, Guo X, Li Z, Jong M, Sankaridurg P, He M
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):34. doi: 10.1167/iovs.61.4.34. PMID: 32334434Free PMC Article
Hendriks M, Verhoeven VJM, Buitendijk GHS, Polling JR, Meester-Smoor MA, Hofman A; RD5000 Consortium, Kamermans M, Ingeborgh van den Born L, Klaver CCW
Am J Ophthalmol 2017 Oct;182:81-89. Epub 2017 Jul 25 doi: 10.1016/j.ajo.2017.07.008. PMID: 28751151
AlBakri A, Ghazi NG, Khan AO
Ophthalmic Genet 2017 Mar-Apr;38(2):138-142. Epub 2016 Apr 18 doi: 10.3109/13816810.2016.1164197. PMID: 27088344

Diagnosis

Palmer E, Stepien KM, Campbell C, Barton S, Iosifidis C, Ghosh A, Broomfield A, Woodall A, Wilcox G, Sergouniotis PI, Black GC
Orphanet J Rare Dis 2023 Sep 4;18(1):265. doi: 10.1186/s13023-023-02840-0. PMID: 37667371Free PMC Article
Jiang Y, Ouyang J, Li S, Xiao X, Sun W, Zhang Q
Mol Vis 2021;27:50-60. Epub 2021 Jan 20 PMID: 33633439Free PMC Article
Hendriks M, Verhoeven VJM, Buitendijk GHS, Polling JR, Meester-Smoor MA, Hofman A; RD5000 Consortium, Kamermans M, Ingeborgh van den Born L, Klaver CCW
Am J Ophthalmol 2017 Oct;182:81-89. Epub 2017 Jul 25 doi: 10.1016/j.ajo.2017.07.008. PMID: 28751151
AlBakri A, Ghazi NG, Khan AO
Ophthalmic Genet 2017 Mar-Apr;38(2):138-142. Epub 2016 Apr 18 doi: 10.3109/13816810.2016.1164197. PMID: 27088344
Iomdina E, Tarutta E, Markossian G, Aksenova J, Smirnova T, Bedretdinov A
Pomeranian J Life Sci 2015;61(2):146-52. doi: 10.21164/pomjlifesci.69. PMID: 27141597

Therapy

Abuallut II, Alhulaibi AA, Alyamani AA, Almalki NM, Alrajhi AA, Alharbi AH, Mahfouz MS
Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):210-217. Epub 2021 Jan 19 doi: 10.4103/meajo.MEAJO_240_20. PMID: 33814817Free PMC Article
Wang Y, Ma J
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):412-416. doi: 10.1097/01.APO.0000580128.27272.bb. PMID: 31490200Free PMC Article
Pan CW, Chen Q, Sheng X, Li J, Niu Z, Zhou H, Wei T, Yuan Y, Zhong H
Invest Ophthalmol Vis Sci 2015 May;56(5):3235-41. doi: 10.1167/iovs.14-16357. PMID: 26024108
Arevalo JF, Lasave AF, Torres F, Suarez E
Graefes Arch Clin Exp Ophthalmol 2012 Jul;250(7):963-70. Epub 2012 Jan 5 doi: 10.1007/s00417-011-1907-2. PMID: 22218710
Rosman M, Alió JL, Ortiz D, Pérez-Santonja JJ
J Refract Surg 2011 Apr;27(4):279-86. Epub 2010 Jul 15 doi: 10.3928/1081597X-20100707-02. PMID: 20672763

Prognosis

Demir P, Baskaran K, Theagarayan B, Gierow P, Sankaridurg P, Macedo AF
Clin Exp Optom 2021 Jul;104(5):595-601. Epub 2021 Mar 2 doi: 10.1080/08164622.2021.1878833. PMID: 33689658
Lee JTL, Guo X, Li Z, Jong M, Sankaridurg P, He M
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):34. doi: 10.1167/iovs.61.4.34. PMID: 32334434Free PMC Article
Wang Y, Ma J
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):412-416. doi: 10.1097/01.APO.0000580128.27272.bb. PMID: 31490200Free PMC Article
Iomdina E, Tarutta E, Markossian G, Aksenova J, Smirnova T, Bedretdinov A
Pomeranian J Life Sci 2015;61(2):146-52. doi: 10.21164/pomjlifesci.69. PMID: 27141597
Arevalo JF, Lasave AF, Torres F, Suarez E
Graefes Arch Clin Exp Ophthalmol 2012 Jul;250(7):963-70. Epub 2012 Jan 5 doi: 10.1007/s00417-011-1907-2. PMID: 22218710

Clinical prediction guides

Demir P, Baskaran K, Theagarayan B, Gierow P, Sankaridurg P, Macedo AF
Clin Exp Optom 2021 Jul;104(5):595-601. Epub 2021 Mar 2 doi: 10.1080/08164622.2021.1878833. PMID: 33689658
Abuallut II, Alhulaibi AA, Alyamani AA, Almalki NM, Alrajhi AA, Alharbi AH, Mahfouz MS
Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):210-217. Epub 2021 Jan 19 doi: 10.4103/meajo.MEAJO_240_20. PMID: 33814817Free PMC Article
Lee JTL, Guo X, Li Z, Jong M, Sankaridurg P, He M
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):34. doi: 10.1167/iovs.61.4.34. PMID: 32334434Free PMC Article
Wang Y, Ma J
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):412-416. doi: 10.1097/01.APO.0000580128.27272.bb. PMID: 31490200Free PMC Article
AlBakri A, Ghazi NG, Khan AO
Ophthalmic Genet 2017 Mar-Apr;38(2):138-142. Epub 2016 Apr 18 doi: 10.3109/13816810.2016.1164197. PMID: 27088344

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