U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agenesis of central incisor

MedGen UID:
381532
•Concept ID:
C1855000
•
Finding
Synonyms: Absent central incisor; Absent central incisors
 
HPO: HP:0006289

Definition

Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAgenesis of central incisor

Conditions with this feature

Mohr syndrome
MedGen UID:
10077
•Concept ID:
C0026363
•
Disease or Syndrome
Orofaciodigital syndrome II (OFD2), also known as Mohr syndrome, is characterized by cleft lip/palate, lobulated tongue with nodules, dental anomalies including tooth agenesis, maxillary hypoplasia, conductive hearing loss, and poly-, syn-, and brachydactyly. Mesomelic shortening of the limbs has also been observed (Mohr, 1941; Gorlin, 1982; Monroe et al., 2016).
See: Condition Record
Central incisors, absence of
MedGen UID:
337110
•Concept ID:
C1844886
•
Finding
See: Condition Record
Central incisors, absence of
Mohr syndrome

Professional guidelines

PubMed

Management of excessive gingival display using botulinum toxin type A: a descriptive study.
Andriola FO, Chieza GS, Cavagni J, Freddo AL, Corsetti A
Toxicon 2021 Jun;196:56-62. Epub 2021 Mar 29 doi: 10.1016/j.toxicon.2021.03.016. PMID: 33794266
Factors affecting treatment duration of labial inversely impacted maxillary central incisors.
Bhikoo C, Xu J, Sun H, Jin C, Jiang H, Hu R
Am J Orthod Dentofacial Orthop 2018 May;153(5):708-715. doi: 10.1016/j.ajodo.2017.09.017. PMID: 29706219
Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.
Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570Free PMC Article

Recent clinical studies

Etiology

Closure of maxillary lateral incisor agenesis space in unilateral cleft lip and palate: a digital model assessment.
Manfio ASC, Garib D, Flores-Mir C, Lauris JRP, Teixeira R, Almeida ALPF
Dental Press J Orthod 2023;28(1):e2321331. Epub 2023 Apr 14 doi: 10.1590/2177-6709.28.1.e2321331.oar. PMID: 37075417Free PMC Article
Prevalence and Etiological Factors of Dental Trauma among 12- and 15-Year-Old Schoolchildren of Lebanon: A National Study.
Abdel Malak C, Chakar C, Romanos A, Rachidi S
ScientificWorldJournal 2021;2021:5587431. Epub 2021 Mar 5 doi: 10.1155/2021/5587431. PMID: 33746633Free PMC Article
Influence of maxillary lateral incisor width ratio on perception of smile esthetics among orthodontists and laypersons.
Martinez Florez D, Rinchuse D, Zullo T
J Esthet Restor Dent 2021 Apr;33(3):510-515. Epub 2020 Nov 6 doi: 10.1111/jerd.12664. PMID: 33155745
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Natal teeth.
Leung AK
Am J Dis Child 1986 Mar;140(3):249-51. doi: 10.1001/archpedi.1986.02140170075033. PMID: 3946356

Diagnosis

Deep phenotyping of the neuroimaging and skeletal features in KBG syndrome: a study of 53 patients and review of the literature.
Peluso F, Caraffi SG, Contrò G, Valeri L, Napoli M, Carboni G, Seth A, Zuntini R, Coccia E, Astrea G, Bisgaard AM, Ivanovski I, Maitz S, Brischoux-Boucher E, Carter MT, Dentici ML, Devriendt K, Bellini M, Digilio MC, Doja A, Dyment DA, Farholt S, Ferreira CR, Wolfe LA, Gahl WA, Gnazzo M, Goel H, Grønborg SW, Hammer T, Iughetti L, Kleefstra T, Koolen DA, Lepri FR, Lemire G, Louro P, McCullagh G, Madeo SF, Milone A, Milone R, Nielsen JEK, Novelli A, Ockeloen CW, Pascarella R, Pippucci T, Ricca I, Robertson SP, Sawyer S, Falkenberg Smeland M, Stegmann S, Stumpel CT, Goel A, Taylor JM, Barbuti D, Soresina A, Bedeschi MF, Battini R, Cavalli A, Fusco C, Iascone M, Van Maldergem L, Venkateswaran S, Zuffardi O, Vergano S, Garavelli L, Bayat A
J Med Genet 2023 Nov 27;60(12):1224-1234. doi: 10.1136/jmg-2023-109141. PMID: 37586838Free PMC Article
Sonography of fetal holoprosencephaly: a guide to recognize the lesser varieties.
Montaguti E, Cariello L, Brunelli E, Youssef A, Livi A, Salsi G, Pilu G
J Matern Fetal Neonatal Med 2022 Dec;35(25):9717-9723. Epub 2022 Mar 10 doi: 10.1080/14767058.2022.2050900. PMID: 35272544
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
CT and MRI of congenital nasal lesions in syndromic conditions.
Ginat DT, Robson CD
Pediatr Radiol 2015 Jul;45(7):1056-65. Epub 2015 Jan 9 doi: 10.1007/s00247-014-3239-y. PMID: 25573243
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Therapy

Prevalence and Etiological Factors of Dental Trauma among 12- and 15-Year-Old Schoolchildren of Lebanon: A National Study.
Abdel Malak C, Chakar C, Romanos A, Rachidi S
ScientificWorldJournal 2021;2021:5587431. Epub 2021 Mar 5 doi: 10.1155/2021/5587431. PMID: 33746633Free PMC Article
Impact of oral-health-related quality of life and self-esteem on patients with missing maxillary lateral incisor after orthodontic space closure: a single-blinded, randomized, controlled trial.
Pithon MM, Vargas EOA, da Silva Coqueiro R, Lacerda-Santos R, Tanaka OM, Maia LC
Eur J Orthod 2021 Apr 3;43(2):208-214. doi: 10.1093/ejo/cjaa075. PMID: 33367539
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355
Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.
Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766Free PMC Article

Prognosis

Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Impacted central incisors: factors affecting prognosis and treatment duration.
Chaushu S, Becker T, Becker A
Am J Orthod Dentofacial Orthop 2015 Mar;147(3):355-62. doi: 10.1016/j.ajodo.2014.11.019. PMID: 25726403
Solitary median maxillary central incisor (SMMCI) syndrome.
Hall RK
Orphanet J Rare Dis 2006 Apr 9;1:12. doi: 10.1186/1750-1172-1-12. PMID: 16722608Free PMC Article
Solitary median maxillary central incisor, short stature, choanal atresia/midnasal stenosis (SMMCI) syndrome.
Hall RK, Bankier A, Aldred MJ, Kan K, Lucas JO, Perks AG
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997 Dec;84(6):651-62. doi: 10.1016/s1079-2104(97)90368-1. PMID: 9431535
Mesiodentes: incidence, morphology, etiology.
Stellzig A, Basdra EK, Komposch G
J Orofac Orthop 1997;58(3):144-53. doi: 10.1007/BF02676545. PMID: 9200890

Clinical prediction guides

Closure of maxillary lateral incisor agenesis space in unilateral cleft lip and palate: a digital model assessment.
Manfio ASC, Garib D, Flores-Mir C, Lauris JRP, Teixeira R, Almeida ALPF
Dental Press J Orthod 2023;28(1):e2321331. Epub 2023 Apr 14 doi: 10.1590/2177-6709.28.1.e2321331.oar. PMID: 37075417Free PMC Article
KBG syndrome: Clinical features and molecular findings in seven unrelated Korean families with a review of the literature.
Choi Y, Choi J, Do H, Hwang S, Seo GH, Choi IH, Keum C, Choi JH, Kang M, Kim GH, Yoo HW, Lee BH
Mol Genet Genomic Med 2023 Apr;11(4):e2127. Epub 2022 Dec 23 doi: 10.1002/mgg3.2127. PMID: 36564961Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Molar incisor hypomineralization: Analysis of asymmetry of lesions.
Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574
KBG syndrome.
Brancati F, Sarkozy A, Dallapiccola B
Orphanet J Rare Dis 2006 Dec 12;1:50. doi: 10.1186/1750-1172-1-50. PMID: 17163996Free PMC Article

Recent systematic reviews

Laser Surgical Approach of Upper Labial Frenulum: A Systematic Review.
Inchingolo AM, Malcangi G, Ferrara I, Viapiano F, Netti A, Buongiorno S, Latini G, Azzollini D, De Leonardis N, de Ruvo E, Mancini A, Rapone B, Venere DD, Patano A, Avantario P, Tartaglia GM, Lorusso F, Scarano A, Sauro S, Fatone MC, Bordea IR, Inchingolo F, Inchingolo AD, Dipalma G
Int J Environ Res Public Health 2023 Jan 11;20(2) doi: 10.3390/ijerph20021302. PMID: 36674058Free PMC Article
Does primary trauma lead to developmental defects in permanent teeth?
Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth.
Ghaeminia H, Nienhuijs ME, Toedtling V, Perry J, Tummers M, Hoppenreijs TJ, Van der Sanden WJ, Mettes TG
Cochrane Database Syst Rev 2020 May 4;5(5):CD003879. doi: 10.1002/14651858.CD003879.pub5. PMID: 32368796Free PMC Article
Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.
Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134
Prosthetic replacement vs space closure for maxillary lateral incisor agenesis: A systematic review.
Silveira GS, de Almeida NV, Pereira DM, Mattos CT, Mucha JN
Am J Orthod Dentofacial Orthop 2016 Aug;150(2):228-37. doi: 10.1016/j.ajodo.2016.01.018. PMID: 27476355

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...